<abstract xmlns="http://www.w3.org/1999/xhtml"> Polyoxometalates are important inorganic compounds with a broad range of pharmacological properties, including antiviral, antibacterial, antiprotozoal or antitumoral activities, even that their molecular mechanism of action is poorly understood. Purpose: In this paper we evaluated the antibacterial activity of some saturated polyoxotungstates (POW) compounds, since nowadays, the increasing resistance of bacteria to drugs represents a major health problem. Materials and methods: The antibacterial activity was studied by disk diffusion method as a possible screening method and by successive micro-dilutions method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) have been calculated for each compound by successive dilutions. We also compared the reliability of each testing method for this particular POW evaluation. Results: The best antibacterial activity was expressed by H4[SiW12O40]*nH2O and the lowest by Na3[PW12O40]*nH2O, but with very good activity on Staphylococcus spp., especially on MRSA. The POW activity occurs only at relatively high concentrations, and it is dependent on bacterial strain, with very good activity on Staphylococcus spp. The most reliable method for assessing the antibacterial effects of POW is micro-dilutions. POWs could be practically applied in hospital decontamination and could have a possible in vivo antibacterial application.</abstract>

Polyoxometalates are important inorganic compounds with a broad range of pharmacological properties, including antiviral, antibacterial, antiprotozoal or antitumoral activities, even that their molecular mechanism of action is poorly understood. Purpose: In this paper we evaluated the antibacterial activity of some saturated polyoxotungstates (POW) compounds, since nowadays, the increasing resistance of bacteria to drugs represents a major health problem. Materials and methods: The antibacterial activity was studied by disk diffusion method as a possible screening method and by successive micro-dilutions method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) have been calculated for each compound by successive dilutions. We also compared the reliability of each testing method for this particular POW evaluation. Results: The best antibacterial activity was expressed by H4[SiW12O40]*nH2O and the lowest by Na3[PW12O40]*nH2O, but with very good activity on Staphylococcus spp., especially on MRSA. The POW activity occurs only at relatively high concentrations, and it is dependent on bacterial strain, with very good activity on Staphylococcus spp. The most reliable method for assessing the antibacterial effects of POW is micro-dilutions. POWs could be practically applied in hospital decontamination and could have a possible in vivo antibacterial application.

Antibacterial activity of some saturated polyoxotungstates

General and Inorganic Chemistry Department, Faculty of Pharmacy

Microbiology, Virology and Parasitology Department, Faculty of Medicine

Drugs Analysis and Analytical Chemistry Department, Faculty of Pharmacy

Organic Chemistry Department, Faculty of Pharmacy

Faculty of Pharmacy University of Medicine and Pharmacy, Tîrgu Mureş

Revista Romana de Medicina de Laborator

{"article-title":"Antibacterial activity of some saturated polyoxotungstates"}

Polyoxometalates are important inorganic compounds with a broad range of pharmacological properties, including antiviral, antibacterial, antiprotozoal or...

Antibacterial activity of some saturated polyoxotungstates

Published Online: Mar 25, 2014

Page range: 111 - 118

DOI: https://doi.org/10.2478/rrlm-2014-0007

Keywords
Polyoxometalates, Polyoxotungstates, Microbial Sensitivity Tests, Anti-Bacterial Agents, Inorganic Chemistry

This content is open access.

Antibacterial activity of some saturated polyoxotungstates

Published Online: Mar 25, 2014

Page range: 111 - 118

DOI: https://doi.org/10.2478/rrlm-2014-0007

KeywordsPolyoxometalates, Polyoxotungstates, Microbial Sensitivity Tests, Anti-Bacterial Agents, Inorganic Chemistry

This content is open access.

Keywords
Polyoxometalates, Polyoxotungstates, Microbial Sensitivity Tests, Anti-Bacterial Agents, Inorganic Chemistry