<abstract xmlns="http://www.w3.org/1999/xhtml"><p> From breast malignant tumors, bone is the most frequent site of metastasis. Bone metastases from breast cancer are correlated with pathological fractures, spinal cord compression and other skeletal-related events as well as bone pain and hypercalcemia. These lead to impaired mobility, decreased quality of life, and overall decrease in survival. Clarification of mechanisms regulating bone metastasis has advanced greatly in the last years and this has translated into plentiful unused therapeutic options. Greater understanding of the pathophysiology of bone metastases has led to the detection and clinical efficiency of bone-targeted agents. This review summarizes the key evidence for current clinical practice and future directions.</p></abstract>

From breast malignant tumors, bone is the most frequent site of metastasis. Bone metastases from breast cancer are correlated with pathological fractures, spinal cord compression and other skeletal-related events as well as bone pain and hypercalcemia. These lead to impaired mobility, decreased quality of life, and overall decrease in survival. Clarification of mechanisms regulating bone metastasis has advanced greatly in the last years and this has translated into plentiful unused therapeutic options. Greater understanding of the pathophysiology of bone metastases has led to the detection and clinical efficiency of bone-targeted agents. This review summarizes the key evidence for current clinical practice and future directions.

Dealing with Bone Metastases from Breast Cancer - A Pathological and Clinical Overview

Romanian Journal of Orthopaedic Surgery and Traumatology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

From breast malignant tumors, bone is the most frequent site of metastasis. Bone metastases from breast cancer are correlated with pathological fractures,...

Dealing with Bone Metastases from Breast Cancer - A Pathological and Clinical Overview

Published Online: May 22, 2018

Page range: 25 - 25

DOI: https://doi.org/10.2478/rojost-2018-0036

Keywords
metastases, bone, breast cancer, pathology

© 2018 O. Munteanu, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Dealing with Bone Metastases from Breast Cancer - A Pathological and Clinical Overview

Published Online: May 22, 2018

Page range: 25 - 25

DOI: https://doi.org/10.2478/rojost-2018-0036

Keywordsmetastases, bone, breast cancer, pathology

© 2018 O. Munteanu, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
metastases, bone, breast cancer, pathology