Rectus Sheath Block in Abdominal Surgery: A Systematic Review with Meta-Analysis
Article Category: Review
Published Online: Apr 20, 2023
Page range: 43 - 50
DOI: https://doi.org/10.2478/rjaic-2023-0006
Keywords
© 2023 Yerkin Abdildin et al., published by sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
One of the major concerns of abdominal surgery patients is postoperative pain and its complications. Poorly controlled postoperative pain not only affects patient recovery but can also increase postoperative opioid use and potential abuse. Contraindications, complications, and the cost of neuraxial analgesia, which is widely used for abdominal surgery, require the exploration of alternative analgesia modalities [1]. Administration of local anaesthetics rather than opioids makes regional analgesia a promising modality for abdominal surgery [2].
Truncal nerve blocks offer relative simplicity and safety of analgesia in abdominal surgery [3]. One of the most common truncal nerve blocks is the transversus abdominis plane (TAP) block, which targets thoracolumbar nerves [3]. All other developed blocks, such as the rectus sheath block (RSB), are often compared against the TAP block.
RSB targets terminal branches of thoracic nerves [4] and is indicated mainly for surgeries with midline vertical incisions [3]. With the evolvement of ultrasound-guided and laparoscopic approaches, RSB promises to be safer now than the former blind approach [4]. These new administration modes reduce not only the mechanical complications of RSB but also the systemic toxicity of local anaesthetics [5]. A couple of systematic reviews demonstrated the efficacy and safety of RSB in the paediatric population [6, 7]. On the other hand, adult studies demonstrated controversial results [1, 4]. Several regional anaesthetic techniques targeting postoperative pain in abdominal surgery have been developed and studied over the past several years [8, 9].
To establish the most appropriate method for postoperative pain management based on the highest level of evidence, the comparison of different methods of regional anaesthesia in the framework of meta-analyses is required.
In this systematic review with meta-analysis, we aimed to explore the efficiency and safety of RSB in abdominal surgery.
We developed a protocol for meta-analysis regarding the inclusion and exclusion criteria for appropriate articles. The protocol and methods were agreed upon by all authors. We sought RCTs in English that studied the effect of RSB in abdominal surgery. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)” [10]. One of the authors searched for relevant articles in PubMed, Google Scholar, and the Cochrane Library that were published before October 2021 (Figure 1). The following search terms or their combination were used during the search: “rectus sheath block”, “abdominal surgery”, “hepatobiliary surgery”, “liver surgery”, “hernia surgery”, “laparotomy”, “caesarean section”, “C-section”.
Figure 1.
PRISMA diagram
Randomised controlled trials (RCTs);
Surgery: abdominal surgery;
Comparators: RSB vs. control;
Articles published in English.
Non-RCTs: retrospective studies, case reports, case series, editorials, cadaver studies, technical reports;
Not adequately described study methodology, assessment, reporting methods.
The primary outcomes of our meta-analysis are postoperative pain intensity and postoperative opioid consumption.
We extracted and entered data in the data table. Means and standard deviations of continuous data were entered in the table. The following rubrics were included: reference, first author, year of publication, country, design and goals of the study, age of participants, type of surgery, sample size, American Society of Anesthesiologists (ASA) physical status, pharmacological agents and adjuvants, and side effects. Data analysis was conducted using the Review Manager software (RevMan, v. 5.4). Data were analysed via mean difference with 95% CIs, using random effects meta-analysis. Statistical heterogeneity was estimated by the I2 statistic. Data for morphine equivalent conversions are taken from:
Equianalgesic opioid conversions. Retrieved from Opioid conversion ratios (February 2021). Retrieved from BCGuidelines.ca. (2017). Equianalgesic Conversion for Morphine. Retrieved from
The methodological quality of the included studies was assessed using the Oxford quality scoring system (Jadad Scale) [11]. The quality of the studies was graded within the range from 1 to 5 as low (<3), acceptable (3), good (4), and excellent (5).
We found 18 articles that matched our search criteria (Figure 1). Eight articles [2, 12–18] with 386 patients (RSB group – 192 and control group – 194) and were selected for meta-analysis (Table 1).
Characteristics of included studies
| Author, citation | Country | Study design | Study goals | Age | Number of patients: total (intervention/control) | Group | Surgery | General anesthesia | ASA | Local anesthetics, volume and concentration | Adjuvants to local anesthetics |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cho et al., 2018 | South Korea | RCT | Primary: post-operative VNRS pain scores, total number of rescue analgesics used in 48 hours after the operation | 21-60 Mean (SD): Intervention –39.6(9.8) Control –41.7(11.3) | 60 (30/30) | Intervention: ultrasound-guided RSB Control: no block | Gynecologic laparoscopic surgery | Yes | I-II | 7.5 mL 0.25% ropi-vacaine bilaterally | Fentanyl, ketorolac |
| Cowlishaw et al., 2017 | - | RCT | Analgesic and antiemetic consumption, pain scores (VAS), nausea, vomiting, and satisfaction | 54-56 | 88 (29/29/30) - (SC/PRS/TAP) | Intervention: TAP – transversus abdominis plane catheter, PRS – posterior rectus sheath catheter, SC – subcutaneous catheter | Mid line Laparotomy surgery | No | 18 mL 0.5% ropivacaine via catheter | Dexamethasone, Metoclopramide, Paracetamol, NSAIDs | |
| Kartalov et al., 2017 | North Macedonia | RCT | Primary: VAS pain scores, total morphine dose over 24 hours | Mean (SD): Intervention –41.3(15.8) Control –42.4(14.7) | 60 (30/30) | Intervention: general anesthesia with RSB Control: no block | Umbilical hernia repair surgery | Yes | I-II | 20 mL 0.25% bupi-vacaine bilaterally | Paracetamol, morphine IV |
| Kauffman et al., 2020 | USA | RCT | Primary: pain score 60 minutes after the PACU arrival Secondary: pain (PACU), length of PACU stay, outpatient pain scores, outpatient opioid use, adverse events. | 10-21 Total: 15.3(3.1), control: 15.8(1.6), intervention: 14.83(4.0) | 48 (24/24) | Intervention: laparoscopic-guided RSB. Control: trans-incisional RSB | Single-incision laparoscopic cholecystectomy surgery (gail-bladder removal) | Yes | I-II | 0.5 mL/kg 0.2% ropivacaine hydrochloride bilaterally (total 1 mL/kg, total maximum dose 10 mL) | Ondansetron IV, dexamethasone, glycopyrrolate |
| Li et al., 2019 | China | RCT | Primary: incidence of positive hemodynamic response at incision, incidence of moderate pain postoperatively Secondary: intraoperative sufentanyl, time to eye opening, time to extubation, time to oxycodone request, duration of sensory block | 46-70 Mean (SD):Group B – 58.0 (8.3), Group C – 56.4 (8.6), Group D – 58.7 (7.1), Group BD – 57.1 (8.3) | 85 (66/19) 1 control group: 19 (Group C) 3 intervention groups: 22 (Group B), 21 (Group D) and 23 (Group BD) | Intervention: ultrasound-guided RSB (Group B), dexmedetomidine infusion (Group D), both RSB and dexmedetomidine (Group BD) Control: nothing (Group C) | Open gastrectomy surgery (stomach removal) | Yes | I-III | Group B: 20 mL 0.375% ropivacaine diluted in 0.9% saline bilaterally only Group D: initial dose 0.6 μg/kg dexmedetomidine followed by continuous infusion 0.2 μg/kg/h during surgery then followed by 10 μg sufentanyl Group BD: combination of Group B analgesics first followed by Group D analgesics | Dexmedetomidine, sufentanyl |
| Murouchi et al., 2015 | USA | RCT | Concentration changes of Ropivacaine and analgesic effects | 18-85 | 22 (11/11) | Intervention: RSB Control: TAPB | laparoscopic ovarian surgery | Yes | I-II | 30mL 0.5% ropivacaine bilaterally, 15mL per side | droperidol, acetaminophen |
| Xu et al., 2018 | China | RCT | Primary: effectiveness and safety | 75-77 | 60 (30/30) -(R+D/R) | Intervention: R+D (10mL0.25% ropivacaine + 0.5 μg/kg dexmedetomidine); R (10 mL 0.25% ropivacaine) | Emergency abdominal surgery | Patient-controlled intravenous analgesia (PCIA) | II-III | 10 mL 0.25% ropivacaine, + 0.5 μg/kg dexmedetomidine bilaterally | Sufentanil, Cardiovascular medications |
| Yentis et al., 1999 | UK | RCT | Pain scores, morphine requirements | 32-71 | 37(21/16) | Intervention: midline incisions Control: transverse incisions | abdominal gynecological surgery | Yes | I-II | Up to 60 ml bupivacaine 0.25% | adrenaline 1:400 000 |
ASA – American Society of Anesthesiologists
RCT – randomized controlled trial
PACU – postanesthesia care unit
RSB – rectus sheath block
VAS – visual analog scale
VNRS – verbal numerical rating scale
The anaesthetics and opioid consumption data (in milligrams of morphine equivalents per kilogram) are depicted in the forest plot below (Figure 2). The overall effect of the model does not favour RSB over control, and the result is not sensitive to the exclusion of any study (standardized mean difference [SMD] with 95% CI: 0.16 [−1.82, 2.14]). The model shows considerable heterogeneity (I2 = 97%). There were 81 patients in the RSB group and 86 in the control group.
Figure 2.
Anaesthetics and opioids consumption (in morphine equivalents, mg/kg).
The overall effect of the model (Figure 3) does not favour RSB over control (SMD with 95% CI: –0.09 [−0.39, 0.22]). We should note that in one study[14] the value of sample standard deviation was zero, so the results of this study were not estimable. However, when zero is replaced by a non-zero value (0.1), the model favours the experimental group.
Figure 3.
Pain intensity (out of 10).
The postoperative time to first opioid/analgesic request (min) was reported in four studies. The overall effect of the model (Figure 4) does not favour RSB over the control (SMD with 95% CI: –0.81 [−3.37, 1.75]). The model shows high heterogeneity (I2 = 98%).
Figure 4.
Time to first opioid/analgesic request (min).
Jadad Scale
| Study or subgroup | Was this study described as randomized? | Was the method used to generate the sequence of randomization appropriate and described? | Was the study described as double-blind? | Was the method of double blind appropriate and described? | Was there a description of withdraw and dropouts? | Total score |
|---|---|---|---|---|---|---|
| Cho 2018 | 1 | 1 | 0 | 0 | 1 | 3 |
| Cowlishaw 2017 | 1 | 1 | 1 | 1 | 1 | 5 |
| Kartalov 2017 | 1 | 0 | 1 | 0 | 0 | 2 |
| Kauffman 2020 | 1 | 0 | 1 | 1 | 1 | 4 |
| Li 2019 | 1 | 1 | 1 | 1 | 1 | 5 |
| Murouchi 2015 | 1 | 0 | 0 | 0 | 0 | 1 |
| Xu 2018 | 1 | 1 | 1 | 0 | 1 | 4 |
| Yentis 1999 | 1 | 1 | 1 | 0 | 0 | 3 |
Our review included eight RCTs from Europe, Northern America, and Asia. Each study supported the efficacy of RSB; however, in our meta-analysis, RSB did not significantly improve pain scores compared to the control. There was no significant difference between RSB and the control in total opioid requirement or in the time to the first opioid request. These results can be explained by the limited analgesic effects of RSB, which cannot substantially improve visceral pain, but rather aims to relax the abdominal wall [3]. There was high heterogeneity for opioid use and low heterogeneity for pain control.
Our results align with the network meta-analysis by Howle et al. [1], which compared various regional analgesia modalities in laparotomic surgeries between January 2010 and January 2021. The authors found that single-shot RSB was superior to the control regarding pain relief only shortly after the surgery but not in the first 24 hours postoperatively. In contradiction, continuous RSB administration demonstrated better results in both pain control and opioid-sparing effects during the first day after surgery [1]. Hamid et al. [4] described laparoscopic studies up to October 2020 and revealed decreased opioid consumption but not pain scores during the first postoperative day in RSB patients. The different surgical approaches studied in these two meta-analyses could influence the difference in opioid use.
Regarding meta-analyses evaluating paediatric studies, Hamill et al. [6] demonstrated that combined RSB and TAP did not reduce opioid use or pain during the first 24 hours. Similar to Howle et al [1], the benefits of the blocks could be seen only immediately after the surgery [6]. All studies included in this meta-analysis used ultrasound-guided RSB. Winnie et al. [7] compared RSB with normal saline and local anaesthetics alone and concluded that RSB could reduce morphine consumption and pain scores in paediatrics better than the control. However, the mean difference between the groups was less than one on the 0–10 scale, which is not clinically significant. A decrease in pain scores after surgery can be considered clinically significant if the difference is more than 20 out of 100, or 2 out of 10 in our case [19]. Zhen et al. [20] compared RSB to local anaesthetics for umbilical hernia repairment in children and found no difference between the groups in terms of pain scores and analgesia use after surgery. Outcomes in the paediatric population were expected to be different from those in adults due to the adjustment of the anaesthetic dose to the weight of children. Nevertheless, the aforementioned systematic reviews demonstrated similar results between these populations.
The decision regarding the use of regional blocks depends on balancing the risks and benefits of these methods. One of the most life-threatening complications of regional anaesthesia is local anaesthetic systemic toxicity. Previous reports showed that anterior abdominal wall blocks could lead to detectable plasma concentrations that might exceed the acceptable thresholds of local anaesthetic systemic toxicity [5]. Therefore, anaesthesiologists should always be aware of the risks of local anaesthetic systemic toxicity [21], and if the regional anaesthesia method does not result in the reduction of pain scores or the dose of opioids, the use of such methods becomes questionable.
Our meta-analysis has several limitations. First, two studies with a high risk of bias were included in this study (Table 2). Second, the pooled population demonstrated high heterogeneity. One of the main sources of heterogeneity is the comparison group, which could be TAP block; RSB block, but with another technique; or nothing. The RSB techniques were also different among the studies: ultrasound, laparoscopic, or blind approaches were used. Another source of heterogeneity is surgery and its approach. Both laparoscopic and open surgeries were compared. The setting and conditions were also quite different among the studies: there were emergency and elective surgeries, and gynaecological and gastrointestinal conditions. Different age groups could also contribute to high heterogeneity: we included studies in children, adults, and the elderly. Finally, different doses and regimens of general and local anaesthetics can influence the outcomes. As a result, we could not compare some other important outcomes, such as safety and recovery.
Rectus sheath block (RSB) did not reduce opioid consumption (in morphine equivalents) after abdominal surgery.
Postoperative pain intensity was not lower in the RSB group when compared with the control group. RSB did not prolong the time to the first opioid/analgesic request compared to the non-RSB option. Therefore, there is no statistically significant evidence in favour of RSB over non-RSB treatment options. Due to the heterogeneity across the studies, it was not possible to compare some other important outcomes. The sensitivity analysis showed that the results of this meta-analysis are not sensitive to the exclusion of studies.
These results are based on a small number of studies, and more randomized controlled trials are needed to evaluate the same outcomes – postoperative pain and opioid use. Other outcomes, such as the length of the hospital stay, quality of recovery (mobilisation, recovery of gastrointestinal function), and side effects would be of value as well.
Currently, RSB does not seem to be superior to placebos for pain control or opioid use reduction after abdominal surgeries for either adults or paediatrics.