Lower, variable intrathecal opioid doses, and the incidence of prolonged fetal heart rate decelerations after combined spinal epidural analgesia for labor: A quality improvement analysis
This work is licensed under the Creative Commons Attribution 4.0 International License.
Leighton BL, DeSimone CA, Norris MC, Ben-David B. Intra-thecal narcotics for labor revisited: the combination of fentanyl and morphine intrathecally provides rapid onset of profound, prolonged analgesia. Anesth Analg 1989; 69: 122-125. doi: 10.1213/00000539-198907000-00023LeightonBLDeSimoneCANorrisMCBen-DavidBIntra-thecal narcotics for labor revisited: the combination of fentanyl and morphine intrathecally provides rapid onset of profound, prolonged analgesia19896912212510.1213/00000539-198907000-00023Open DOISearch in Google Scholar
Hess PE, Pratt SD, Lucas TP, Miller CG, Corbett T, Oriol N, et al. Predictors of breakthrough pain during labor epidural analgesia. Anesth Analg 2001; 93: 414–418. doi: 10.1213/00000539200108000-00036HessPEPrattSDLucasTPMillerCGCorbettTOriolNet alPredictors of breakthrough pain during labor epidural analgesia20019341441810.1213/00000539200108000-00036Open DOISearch in Google Scholar
Collis RE, Davies DWL, Aveling W. Randomised comparison of combined spinal-epidural and standard epidural analgesia in labour. Lancet 1995; 345: 1413–1416. doi: 10.1016/s0140-6736(95)92602-xCollisREDaviesDWLAvelingWRandomised comparison of combined spinal-epidural and standard epidural analgesia in labour19953451413141610.1016/s0140-6736(95)92602-xOpen DOISearch in Google Scholar
Hepner DL, Gaiser RR, Cheek TG, Gutsche BB. Comparison of combined spinal-epidural and low dose epidural for labour analgesia. Can J Anaesth 2000; 47: 232–236. doi: 10.1007/bf03018918HepnerDLGaiserRRCheekTGGutscheBBComparison of combined spinal-epidural and low dose epidural for labour analgesia20004723223610.1007/bf0301891810730733Open DOISearch in Google Scholar
Dresner M, Bamber J, Calow C, Freeman J, Charlton P. Comparison of low-dose epidural with combined spinal-epidural analgesia for labour. Br J Anaesth 1999; 83: 756–760. doi: 10.1093/bja/83.5.756DresnerMBamberJCalowCFreemanJCharltonPComparison of low-dose epidural with combined spinal-epidural analgesia for labour19998375676010.1093/bja/83.5.75610690139Open DOISearch in Google Scholar
Price C, Lafreniere L, Brosnan C, Findley I. Regional analgesia in early active labour: combined spinal epidural vs. epidural. Anaesthesia 1998; 53: 951–955. doi: 10.1046/j.1365-2044.1998.00523.xPriceCLafreniereLBrosnanCFindleyIRegional analgesia in early active labour: combined spinal epidural vs19985395195510.1046/j.1365-2044.1998.00523.x9893537Open DOISearch in Google Scholar
Nickells JS, Vaughan DJA, Lillywhite NK, Loughnan B, Hasan M, Robinson PN. Speed of onset of regional analgesia in labour: a comparison of the epidural and spinal routes. Anaesthesia 2000; 55: 17–20. doi: 10.1046/j.1365-2044.2000.01071.xNickellsJSVaughanDJALillywhiteNKLoughnanBHasanMRobinsonPNSpeed of onset of regional analgesia in labour: a comparison of the epidural and spinal routes200055172010.1046/j.1365-2044.2000.01071.x10594428Open DOISearch in Google Scholar
Wong CA, Scavone BM, Peaceman AM, McCarthy RJ, Sullivan JT, Diaz NT, et al. The risk of cesarean delivery with neuraxial analgesia given early versus late in labor. N Eng J Med 2005; 352: 655-665. doi: 10.1056/nejmoa042573WongCAScavoneBMPeacemanAMMcCarthyRJSullivanJTDiazNTet alThe risk of cesarean delivery with neuraxial analgesia given early versus late in labor200535265566510.1056/nejmoa04257315716559Open DOISearch in Google Scholar
Norris MC, Grieco WM, Borkowski M, Leighton BL, Arkoosh VA, Huffnagle HJ, et al. Complications of labor analgesia: epidural versus combined spinal epidural techniques. Anesth Analg 1994; 79: 529–537. doi: 10.1213/00000539-199409000-00022NorrisMCGriecoWMBorkowskiMLeightonBLArkooshVAHuffnagleHJet alComplications of labor analgesia: epidural versus combined spinal epidural techniques19947952953710.1213/00000539-199409000-000228067559Open DOISearch in Google Scholar
Beilin Y, Leibowitz AB, Bernstein HH, Abramovitz SE. Controversies of Labor Epidural Analgesia. Anesth Analg 1999; 89: 969–978. doi: 10.1213/00000539-199910000-00028BeilinYLeibowitzABBernsteinHHAbramovitzSEControversies of Labor Epidural Analgesia19998996997810.1213/00000539-199910000-00028Open DOISearch in Google Scholar
Nageotte MP, Larson D, Rumney PJ, Sidhu M, Hollenbach K. Epidural analgesia compared with combined spinal–epidural analgesia during labor in nulliparous women. N Engl J Med 1997; 337: 1715–1719. doi: 10.1056/nejm199712113372402NageotteMPLarsonDRumneyPJSidhuMHollenbachKEpidural analgesia compared with combined spinal–epidural analgesia during labor in nulliparous women19973371715171910.1056/nejm199712113372402Open DOISearch in Google Scholar
Mardirosoff C, Dumont L, Boulvain M, Tramèr MR. Fetal bradycardia due to intrathecal opioids for labour analgesia: a systematic review. Br J Obstet Gynaecol 2002; 109: 274–281. doi: 10.1016/s1470-0328(02)01380-0MardirosoffCDumontLBoulvainMTramèrMRFetal bradycardia due to intrathecal opioids for labour analgesia: a systematic review200210927428110.1016/s1470-0328(02)01380-0Open DOISearch in Google Scholar
Caldwell LE, Rosen MA, Shnider SM. Subarachnoid morphine and fentanyl for labor analgesia. Eficacy and adverse effects. Region Anesth 1994; 19: 2–8CaldwellLERosenMAShniderSMSubarachnoid morphine and fentanyl for labor analgesia19941928Search in Google Scholar
DeBalli P, Breen TW. Intrathecal opioids for combined spinal-epidural analgesia during labour. CNS Drugs 2003; 17: 889– 904. doi: 10.2165/00023210-200317120-00003DeBalliPBreenTW.Intrathecal opioids for combined spinal-epidural analgesia during labour200317889–90410.2165/00023210-200317120-00003Open DOISearch in Google Scholar
Simmons SW, Taghizadeh N, Dennis AT, Hughes D, Cyna AM. Combined spinal-epidural versus epidural analgesia in labour. Cochrane Db Syst Rev 2012; 10: CD003401. doi: 10.1002/14651858.cd003401.pub3SimmonsSWTaghizadehNDennisATHughesDCynaAMCombined spinal-epidural versus epidural analgesia in labour201210CD00340110.1002/14651858.cd003401.pub3Open DOISearch in Google Scholar
Friedlander J, Fox H, Cain C, Dominguez C, Smiley R. Fetal bradycardia and uterine hyperactivity following subarachnoid administration of fentanyl during labor. Reg Anesth 1997; 22: 378–381FriedlanderJFoxHCainCDominguezCSmileyRFetal bradycardia and uterine hyperactivity following subarachnoid administration of fentanyl during labor19972237838110.1016/S1098-7339(97)80015-6Search in Google Scholar
Van de Velde M, Vercauteren M, Vandermeersch E. Fetal heart rate abnormalities after regional analgesia for labor pain: The efect of intrathecal opioids. Region Anesth Pain M 2001; 26: 257–262. doi: 10.1053/rapm.2001.22258Vande Velde MVercauterenMVandermeerschE.Fetal heart rate abnormalities after regional analgesia for labor pain: The efect of intrathecal opioids20012625726210.1053/rapm.2001.22258Open DOISearch in Google Scholar
Wong CA, Scavone BM, Slavenas JP, Vidovich MI, Peaceman AM, Ganchiff JN, et al. Eficacy and side efect profile of varying doses of intrathecal fentanyl added to bupivacaine for labor analgesia. Int J Obstet Anesth 2004; 13: 19–24. doi: 10.1016/s0959-289x(03)00106-7WongCAScavoneBMSlavenasJPVidovichMIPeacemanAMGanchiffJNet alEficacy and side efect profile of varying doses of intrathecal fentanyl added to bupivacaine for labor analgesia200413192410.1016/s0959-289x(03)00106-7Open DOISearch in Google Scholar
Van de Velde M. Neuraxial analgesia and fetal bradycardia. Curr Opin Anesthesio 2005; 18: 253–256. doi: 10.1097/01.aco.0000169230.53067.49Vande Velde MNeuraxial analgesia and fetal bradycardia20051825325610.1097/01.aco.0000169230.53067.4916534346Open DOISearch in Google Scholar
Skupski DW, Abramovitz S, Samuels J, Pressimone V, Kjaer K. Adverse effects of combined spinal-epidural versus traditional epidural analgesia during labor. Int J Gynecol Obstet 2009; 106: 242–245. doi: 10.1016/j.ijgo.2009.04.019SkupskiDWAbramovitzSSamuelsJPressimoneVKjaerKAdverse effects of combined spinal-epidural versus traditional epidural analgesia during labor200910624224510.1016/j.ijgo.2009.04.01919481203Open DOISearch in Google Scholar
Asokumar B, Newman LM, McCarthy RJ, Ivankovich AD, Tuman KJ. Intrathecal bupivacaine reduces pruritus and prolongs duration of fentanyl analgesia during labor. Anesth Analg 1998; 87: 1309–1315. doi: 10.1213/00000539-199812000-00018AsokumarBNewmanLMMcCarthyRJIvankovichADTumanKJIntrathecal bupivacaine reduces pruritus and prolongs duration of fentanyl analgesia during labor1998871309131510.1213/00000539-199812000-00018Open DOISearch in Google Scholar
Palmer CM, Cork RC, Hays R, Maren GV, Alves D. The dose-response relation of intrathecal fentanyl for labor analgesia. Anesthesiology 1998; 88: 355–361. doi: 10.1097/00000542199802000-00014PalmerCMCorkRCHaysRMarenGVAlvesDThe dose-response relation of intrathecal fentanyl for labor analgesia19988835536110.1097/00000542199802000-00014Open DOISearch in Google Scholar
Palmer CM, Maciulla JE, Cork RC, Nogami WM, Gossler K, Alves D. The incidence of fetal heart rate changes after intrathecal fentanyl labor analgesia. Anesth Analg 1999; 88: 577–581. doi: 10.1213/00000539-199903000-00021PalmerCMMaciullaJECorkRCNogamiWMGosslerKAlvesDThe incidence of fetal heart rate changes after intrathecal fentanyl labor analgesia19998857758110.1213/00000539-199903000-00021Open DOISearch in Google Scholar
Wikner M, Bamber J. Quality improvement in obstetric anaesthesia. Int J Obstet Anesth 2018; 35: 1–3. doi: 10.1016/j.ijoa.2018.03.009WiknerMBamberJQuality improvement in obstetric anaesthesia2018351310.1016/j.ijoa.2018.03.00929914781Open DOISearch in Google Scholar
Segal S, Csavoy AN, Datta S. The tocolytic efect of catecholamines in the gravid rat uterus. Anesth Analg 1998 ;87: 864– 869. doi: 10.1213/00000539-199810000-00022SegalSCsavoyANDattaSThe tocolytic efect of catecholamines in the gravid rat uterus199887864–86910.1213/00000539-199810000-00022Open DOISearch in Google Scholar
Clarke VT, Smiley RM, Finster M. Uterine Hyperactivity after intra-thecal injection of fentanyl for analgesia during labor. Anesthesiology 1994; 81: 1083. doi: 10.1097/00000542-199410000-00041ClarkeVTSmileyRMFinsterMUterine Hyperactivity after intra-thecal injection of fentanyl for analgesia during labor199481108310.1097/00000542-199410000-000417943823Open DOISearch in Google Scholar
Abrão KC, Francisco RPV, Miyadahira S, Cicarelli DD, Zugaib M. Elevation of uterine basal tone and fetal heart rate abnormalities after labor analgesia. Obstet Gynecol 2009; 113: 41–47. doi: 10.1097/aog.0b013e31818f5eb6AbrãoKCFranciscoRPVMiyadahiraSCicarelliDDZugaibM.Elevation of uterine basal tone and fetal heart rate abnormalities after labor analgesia2009113414710.1097/aog.0b013e31818f5eb6Open DOISearch in Google Scholar
Grangier L, Martinez de Tejada B, Savoldelli GL, Irion O, Haller G. Adverse side effects and route of administration of opioids in combined spinal-epidural analgesia for labour: a meta-analysis of randomised trials. Int J Obstet Anesth 2020; 41: 83–103. doi: 10.1016/j.ijoa.2019.09.004GrangierLMartinezde Tejada BSavoldelliGLIrionOHallerG.Adverse side effects and route of administration of opioids in combined spinal-epidural analgesia for labour: a meta-analysis of randomised trials2020418310310.1016/j.ijoa.2019.09.00431704251Open DOISearch in Google Scholar
Nicolet J, Miller A, Kaufman I, Guertin MC, Deschamps A. Maternal factors implicated in fetal bradycardia after combined spinal epidural for labour pain. Eur J Anaesth 2008; 25: 721–725. doi: 10.1017/s0265021508004183NicoletJMillerAKaufmanIGuertinMCDeschampsAMaternal factors implicated in fetal bradycardia after combined spinal epidural for labour pain20082572172510.1017/s026502150800418318400139Open DOISearch in Google Scholar
Cascio M, Pygon B, Bernett C, Ramanathan S. Labour analgesia with intrathecal fentanyl decreases maternal stress. Can J Anaesth 1997; 44: 605–609. doi: 10.1007/bf03015443CascioMPygonBBernettCRamanathanSLabour analgesia with intrathecal fentanyl decreases maternal stress19974460560910.1007/bf03015443Open DOISearch in Google Scholar
Mandell GL, Jamnback L, Ramanathan S. Hemodynamic effects of subarachnoid fentanyl in laboring parturients. Region Anesth 1996; 21: 103–11MandellGLJamnbackLRamanathanSHemodynamic effects of subarachnoid fentanyl in laboring parturients19962110311Search in Google Scholar
Van de Velde M, Teunkens A, Hanssens M, Vandermeersch E, Verhaeghe J. Intrathecal sufentanil and fetal heart rate abnormalities: a double-blind, double placebo-controlled trial comparing two forms of combined spinal epidural analgesia with epidural analgesia in labor. Anesth Analg 2004; 98: 1153–1159. doi: 10.1213/01.ane.0000101980.34587.66Vande Velde MTeunkensAHanssensMVandermeerschEVerhaegheJ.Intrathecal sufentanil and fetal heart rate abnormalities: a double-blind, double placebo-controlled trial comparing two forms of combined spinal epidural analgesia with epidural analgesia in labor2004981153115910.1213/01.ane.0000101980.34587.66Open DOISearch in Google Scholar
Nelson KE, Rauch T, Terebuh V, D’Angelo R. A comparison of intra-thecal fentanyl and sufentanil for labor analgesia. Anesthesiology 2002; 96: 1070–1073. doi: 10.1097/00000542-200205000-00007NelsonKERauchTTerebuhVD’AngeloR.A comparison of intra-thecal fentanyl and sufentanil for labor analgesia2002961070107310.1097/00000542-200205000-0000711981144Open DOISearch in Google Scholar
Hallgrimsdottir H, Shumka L, Althaus C, Benoit C. Fear, risk, and the responsible choice: risk narratives and lowering the rate of caesarean sections in high-income countries. Aims Public Health 2017; 4: 615–632. doi: 10.3934/publi-chealth.2017.6.615HallgrimsdottirHShumkaLAlthausCBenoitCFear, risk, and the responsible choice: risk narratives and lowering the rate of caesarean sections in high-income countries2017461563210.3934/publi-chealth.2017.6.615Open DOISearch in Google Scholar
Lo W, Chong J, Chen L. Combined spinal epidural for labour analgesia--duration, efficacy and side effects of adding sufentanil or fentanyl to bupivacaine intrathecally vs plain bupivacaine. Singapore Med J 1999; 40: 639–43LoWChongJChenLCombined spinal epidural for labour analgesia--duration, efficacy and side effects of adding sufentanil or fentanyl to bupivacaine intrathecally vs plain bupivacaine19994063943Search in Google Scholar