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The clinical significance of fluctuations in the minute-to-minute urine flow rate and in its minute-to-minute variability during septic events in critically ill patients


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Figure 1

Correlation of urine flow rate variability (UFRV) (A) and urine flow rate (UFR) (B) with mean arterial pressure (MAP) at the time of new septic events (black arrows) and following initial fluid resuscitation (red arrows). Note that the UFRV and the UFR decreased progressively in parallel with the falling MAP and rose again after the administration of fluids
Correlation of urine flow rate variability (UFRV) (A) and urine flow rate (UFR) (B) with mean arterial pressure (MAP) at the time of new septic events (black arrows) and following initial fluid resuscitation (red arrows). Note that the UFRV and the UFR decreased progressively in parallel with the falling MAP and rose again after the administration of fluids

Laboratory and clinical data of the 50 study group patients (mean ± SD).

TIME1

TIME1 – vital signs during the 3 hours following admission to the ICU; TIME2 – vital signs 9 hours after the septic event.

TIME2

TIME1 – vital signs during the 3 hours following admission to the ICU; TIME2 – vital signs 9 hours after the septic event.

p value

A p value of less than 0.05 is considered to be statistically significant.

Mean arterial blood pressure (mmHg)94.53 ± 14.8488.21 ± 13.620.06
Heart rate (beat/min)105.48 ±19.38108.05 ± 20.500.06
Urine output per hour (mL)147.56 ± 28.187.53 ± 15.8<0.001
Minute-to-minute urine flow rate

Minute-to-minute urine flow rate is denoted as mL/hour urine volume as measured every minute by the URINFO 2000™ urinometer.

(mL/hour)
146.65 ± 117.30106.65±72.0<0.001
Urine flow rate variability (mean, mL)5.18 ± 9.402.63 ± 3.35<0.001
Hemoglobin (g\dL)9.43 ± 1.169.03 ± 0.120.2
White blood cell count (k/ mm3)9.9 ± 3.415.9±1.450.01
Bicarbonate arterial blood (mEq/L)26.3 ± 4.3520.3 ± 1.350.03
pH arterial blood7.41 ± 0.017.31 ± 0.030.06
Arterial blood lactate (mmol/L)1.19 ± 0.702.5 ± 1.40.04
Urea (mg/dL)54 ± 15.574 ± 7.20.06
Creatinine (mg/dL)0.8 ± 0.030.9 ± 0.10.08
Body temperature (°C)36.08 ± 0.0538.98 ± 0.050.03

Demographic data and APACHE IIAcute Physiology and Chronic Health Evaluation II. scores on admission.

Septic critically ill patients (n = 50)58.80 ± 19.74
Age, years (mean ± SD)58.80 ± 19.74
Gender (male)31 (61%)
Weight, kg (mean ± SD)84.19 ± 22.64
APACHE II score (units, mean ± SD)21.68 ± 4.9
eISSN:
2502-0307
Language:
English
Publication timeframe:
2 times per year
Journal Subjects:
Medicine, Clinical Medicine, other, Surgery, Anaesthesiology, Emergency Medicine and Intensive-Care Medicine