<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2020-0069_s_006_w2aab3b7c28b1b6b1aab1c16b1Aa"><h3>Background</h3><p>The aim of the study was evaluation of <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography with computed tomography (PET/CT) in the detection of active disease in the patients with suspected recurrence of the medullary thyroid carcinoma (MTC).</p></sec><sec id="j_raon-2020-0069_s_007_w2aab3b7c28b1b6b1aab1c16b2Aa"><h3>Patients and methods</h3><p><sup>18</sup>F-FDG PET/CT investigation was performed in 67 patients, investigated from 2010 to 2019. _ Follow up was performed from 6 to 116 months after surgery (median 16.5 months, x± SD = 29±28.9 months). Twenty five of 67 patients underwent <sup>99m</sup>Tc-dimercaptosuccinic acid (<sup>99m</sup>Tc-DMSA) scintigraphy, 11 underwent somatostatin receptor scintigraphy (SRS) with <sup>99m</sup>Tc-HYNIC TOC while 11 <sup>123</sup>I-metaiodobenzylguanidine (MIBG) scintigraphy.</p></sec><sec id="j_raon-2020-0069_s_008_w2aab3b7c28b1b6b1aab1c16b3Aa"><h3>Results</h3><p>From 67 patients, 35 (52.2%) had true positive <sup>18</sup>F-FDG PET/CT findings (TP). Average maximal standardized uptake value (SUVmax) for all TP lesions was 5.01+3.6. In 25 (37.3%) patients findings were true negative (TN). Four (6%) patients had false positive (FP) findings while three (4.5%) were false negative (FN). Thus, sensitivity of the <sup>18</sup>F-FDG PET/ CT was 92.11%, specificity 86.21%, positive predictive value 89.74%, negative predictive value 89.29% and accuracy 89.55%. In 27 patients (40%) <sup>18</sup>F-FDG PET/CT finding influenced further management of the patient.</p></sec><sec id="j_raon-2020-0069_s_009_w2aab3b7c28b1b6b1aab1c16b4Aa"><h3>Conclusions</h3><p><sup>18</sup>F-FDG PET/CT has high accuracy in the detection of metastases/recurrences of MTC in patients after thyroidectomy as well as in evaluation and the appropriate choice of the therapy.</p></sec></abstract>

BackgroundThe aim of the study was evaluation of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography with computed tomography (PET/CT) in the detection of active disease in the patients with suspected recurrence of the medullary thyroid carcinoma (MTC).Patients and methods18F-FDG PET/CT investigation was performed in 67 patients, investigated from 2010 to 2019. _ Follow up was performed from 6 to 116 months after surgery (median 16.5 months, x± SD = 29±28.9 months). Twenty five of 67 patients underwent 99mTc-dimercaptosuccinic acid (99mTc-DMSA) scintigraphy, 11 underwent somatostatin receptor scintigraphy (SRS) with 99mTc-HYNIC TOC while 11 123I-metaiodobenzylguanidine (MIBG) scintigraphy.ResultsFrom 67 patients, 35 (52.2%) had true positive 18F-FDG PET/CT findings (TP). Average maximal standardized uptake value (SUVmax) for all TP lesions was 5.01+3.6. In 25 (37.3%) patients findings were true negative (TN). Four (6%) patients had false positive (FP) findings while three (4.5%) were false negative (FN). Thus, sensitivity of the 18F-FDG PET/ CT was 92.11%, specificity 86.21%, positive predictive value 89.74%, negative predictive value 89.29% and accuracy 89.55%. In 27 patients (40%) 18F-FDG PET/CT finding influenced further management of the patient.Conclusions18F-FDG PET/CT has high accuracy in the detection of metastases/recurrences of MTC in patients after thyroidectomy as well as in evaluation and the appropriate choice of the therapy.

Clinical relevance of <sup>18</sup>F-FDG PET/CT in the postoperative follow-up of patients with history of medullary thyroid cancer

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Clinical relevance of F-FDG PET/CT in the postoperative follow-up of patients with history of medullary thyroid cancer

BackgroundThe aim of the study was evaluation of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography with computed tomography (PET/CT) in the...

Clinical relevance of ¹⁸F-FDG PET/CT in the postoperative follow-up of patients with history of medullary thyroid cancer

Article Category: Research Article

Published Online: Nov 22, 2020

Page range: 18 - 25

Received: Aug 06, 2020

Accepted: Oct 17, 2020

DOI: https://doi.org/10.2478/raon-2020-0069

© 2021 Jelena Saponjski, Djuro Macut, Dragana Sobic Saranovic, Branislava Radovic, Vera Artiko, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Clinical relevance of 18F-FDG PET/CT in the postoperative follow-up of patients with history of medullary thyroid cancer

Article Category: Research Article

Published Online: Nov 22, 2020

Page range: 18 - 25

Received: Aug 06, 2020

Accepted: Oct 17, 2020

DOI: https://doi.org/10.2478/raon-2020-0069

© 2021 Jelena Saponjski, Djuro Macut, Dragana Sobic Saranovic, Branislava Radovic, Vera Artiko, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Clinical relevance of ¹⁸F-FDG PET/CT in the postoperative follow-up of patients with history of medullary thyroid cancer