Variable | |
---|---|
Male gender, n (%) | 96 (84) |
Age, years, median (IQR) | 67 (60–72) |
ECOG performance status | |
0 | 31 (27) |
1 | 47 (40.9) |
2 | 36 (31.3) |
3 | 1 (0.9) |
Aetiology of underlying liver disease, n (%) | |
Alcoholic liver disease | 56 (49) |
Hepatitis B | 11 (9.6) |
Hepatitis C | 7 (6.1) |
Non-alcoholic steatohepatitis | 18 (15.7) |
Cryptogenic | 10 (8.7) |
Wilson’s disease | 1 (0.9) |
Primary biliary cholangitis | 1 (0.9) |
HCC in non-cirrhotic liver | 11 (9.6) |
Child-Pugh class, n (%) | |
A | 77 (66.9) |
B | 37 (32.2) |
C | 1 (0.9) |
BCLC stage, n (%) | |
A | 3 (2.6) |
B | 42 (36.5) |
C | 70 (60.9) |
Prior treatment, n (%) | 45 (39.1) |
Resection | 10 (8.7) |
RFA | 2 (1.8) |
Transplant | 3 (2.6) |
TACE | 29 (25.2) |
Radioembolization | 5 (4.3) |
AFP, kU/L, median (IQR) | 6–1518) |
Univariable analysis | Multivariable analysis | |||
---|---|---|---|---|
Median survival in months (95% CI) | Log rank | Hazard ratio (95% CI) | Cox’s regression | |
ECOG performance status | ||||
0 | 25.1 (12.8–37.4) | |||
1 | 17.0 (7.0–26.9) | <0.0001 | 2.21 (1.56–3.16) | <0.0001 |
2 | 5.5 (3.7–7.3) | |||
3 | 7.3 (/) | |||
Child-Pugh class | ||||
A | 16.9 (12.8–21.0) | |||
B | 6.7 (4.7–8.7) | <0.0001 | 1.00 1.34 (0.80–2.26) | 0.271 |
C | 1.0 (/) | 52.4 (3.20–859) | 0.005 | |
Baseline AFP | ||||
< 200 | 17.0 (9.3–24.6) | 0.003 | 1.00 (0.8–1.2) | 0.278 |
≥ 200 | 6.7 (5.6–7.8) | |||
Prior locoregional treatment | ||||
Yes | 24.0 (20.1–27.9) | <0.0001 | 1.00 | |
No | 7.3 (5.0–9.5) | 2.30 (1.37–3.86) | 0.002 | |
Liver disease aetiology | ||||
Alcoholic | 8.6 (3.80–13.3) | 0.192 | ||
Other | 16.7 (13.5–19.9) | |||
BCLC stage | ||||
A | 22.4 (7.0–37.7) | |||
B | 14.5 (5.1–23.9) | 0.539 | ||
C | 13.4 (7.1–19.7) | |||
Gender | ||||
Female | 8.8 (7.0–10.7) | 0.944 | ||
Male | 13.8 (10.1–17.6) | |||
Age | ||||
< 70 years | 15.0 (11.2–18.8) | 0.201 | ||
≥ 70 years | 8.4 (6.0–10.8) |