This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem 2000; 275: 9390-5. doi: 10.1074/jbc.275.13.9390RogakouEPNieves-NeiraWBoonCPommierYBonnerWMInitiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139J Biol Chem20002759390510.1074/jbc.275.13.939010734083Open DOISearch in Google Scholar
Antonelli F, Belli M, Cuttone G, Dini V, Esposito G, Simone G, et al. Induction and repair of DNA double –strand breaks in human cells: dephosphorylation of histone H2AX and its inhibition by calyculin A. Radiat Res 2005; 164: 514-7. doi: 10.1667/rr3379.1AntonelliFBelliMCuttoneGDiniVEspositoGSimoneGet alInduction and repair of DNA double –strand breaks in human cells: dephosphorylation of histone H2AX and its inhibition by calyculin ARadiat Res2005164514710.1667/rr3379.116187759Open DOISearch in Google Scholar
Bourton EC, Plowman PN, Smith D, Arlett CF, Parris CN. Prolonged expression of the gamma-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment. Int J Cancer 2011; 129: 2928-34. doi: 10.1002/ijc.25953BourtonECPlowmanPNSmithDArlettCFParrisCNProlonged expression of the gamma-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatmentInt J Cancer201112929283410.1002/ijc.25953342788221491423Open DOISearch in Google Scholar
Li P, Du C, Xu W, Shi Z, Zhang Q, Li Z, et al. Correlation of dynamic changes in γ-H2AX expression in peripheral blood lymphocytes from head and neck cancer patients with radiation induced oral mucositis. Radiat Oncol 2013; 8: 155. doi: 10.1186/1748-717X-8-155LiPDuCXuWShiZZhangQLiZet alCorrelation of dynamic changes in γ-H2AX expression in peripheral blood lymphocytes from head and neck cancer patients with radiation induced oral mucositisRadiat Oncol2013815510.1186/1748-717X-8-155370783523803252Open DOISearch in Google Scholar
Maria OM, Eliopoulos N, Muanza T. Radiation – induced mucositis. Front Oncol 2017; 7: 89. doi: 10.3389/fonc.2017.00089MariaOMEliopoulosNMuanzaTRadiation – induced mucositisFront Oncol201778910.3389/fonc.2017.00089543912528589080Open DOISearch in Google Scholar
U.S.Department of Health and Human Services. National Institutes of Health. National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. [cited 2019 Nov 15]. Available at: https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/Archive/CTCAE_4.0_2009-05-29_QuickReference_8.5x11.pdfU.S.Department of Health and Human ServicesNational Institutes of Health. National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. [cited 2019 Nov 15]Available athttps://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/Archive/CTCAE_4.0_2009-05-29_QuickReference_8.5x11.pdfSearch in Google Scholar
Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspectives on cancer therapy – induced mucosal injury. Cancer Suppl 2004; 100: 1995-2025. doi: 10.1002/cncr.20162SonisSTEltingLSKeefeDPetersonDESchubertMHauer-JensenMet alPerspectives on cancer therapy – induced mucosal injuryCancer Suppl20041001995202510.1002/cncr.2016215108222Open DOISearch in Google Scholar
Puliliou S, Koukourakis MI. Gamma histone 2AX (γ-H2AX) as a predictive tool in radiation oncology. Biomarkers 2014; 19: 167-80. doi: 10.3109/1354750X.2014.898099PuliliouSKoukourakisMIGamma histone 2AX (γ-H2AX) as a predictive tool in radiation oncologyBiomarkers2014191678010.3109/1354750X.2014.89809924611829Open DOISearch in Google Scholar
Beaton LA, Marro L, Malone S, Samiee S, Grimes S, Malone K, et al. Investigating γ-H2AX as a biomarker of radiosensitivity using flow cytometry methods. ISRN Radiol 2013; 10: 1-7. doi: 10.5402/2013/704659BeatonLAMarroLMaloneSSamieeSGrimesSMaloneKet alInvestigating γ-H2AX as a biomarker of radiosensitivity using flow cytometry methodsISRN Radiol2013101710.5402/2013/704659404552224967288Open DOISearch in Google Scholar
Vasireddy RS, Sprung CN, Cempaka NL, Chao M, McKay MJ. H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype. Br J Cancer 2010; 102: 1511-8. doi: 10.1038/sj.bjc.6605666VasireddyRSSprungCNCempakaNLChaoMMcKayMJH2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotypeBr J Cancer20101021511810.1038/sj.bjc.6605666286916620461094Open DOISearch in Google Scholar
Fleckenstein J, Kuhne M, Seegmuller K, Derschang S, Melchior P, Graber S, et al. The impact of individual in vivo repair of DNA double-strand breaks on oral mucositis in adjuvant radiotherapy of head and neck cancer. Int J Radiat Oncol Biol Phys 2011; 81: 1465-72. doi: 10.1016/j.ijrobp.2010.08.004FleckensteinJKuhneMSeegmullerKDerschangSMelchiorPGraberSet alThe impact of individual in vivo repair of DNA double-strand breaks on oral mucositis in adjuvant radiotherapy of head and neck cancerInt J Radiat Oncol Biol Phys20118114657210.1016/j.ijrobp.2010.08.00420947264Open DOISearch in Google Scholar
Goutham VH, Mumbrekar KD, Phil M, Vadhiraja BM, Fernandes DJ, Sharan K, et al. DNA double –strand breaks analysis by γ-H2AX foci: a useful method for determining the overreactors to radiation – induced acute reactions among head and neck cancer patients. Int J Radiat Oncol Biol Phys 2012; 84: 607-12. doi: 10.1016/j.ijrobp.2012.06.041GouthamVHMumbrekarKDPhilMVadhirajaBMFernandesDJSharanKet alDNA double –strand breaks analysis by γ-H2AX foci: a useful method for determining the overreactors to radiation – induced acute reactions among head and neck cancer patientsInt J Radiat Oncol Biol Phys2012846071210.1016/j.ijrobp.2012.06.04122836053Open DOISearch in Google Scholar
Torras MG, Fundowicz M, Aliste L, Asensio E, Boladeras AM, Borras JM, et al. Improving radiation oncology through clinical audits: introducing the IROCA project. Rep Pract Oncol Radiother 2017; 22: 408-14. doi: 10.1016/j.rpor.2017.07.004TorrasMGFundowiczMAlisteLAsensioEBoladerasAMBorrasJMet alImproving radiation oncology through clinical audits: introducing the IROCA projectRep Pract Oncol Radiother2017224081410.1016/j.rpor.2017.07.004555496328831281Open DOISearch in Google Scholar
Sak A, Grehl S, Erichsen P, Engelhard M, Grannass A, Levegrun S, et al. Gamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: dependence on the dose-distribution, irradiated site and time from start of treatment. Int J Radiat Biol 2007; 83: 639-65. doi: 10.1080/09553000701596118SakAGrehlSErichsenPEngelhardMGrannassALevegrunSet alGamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: dependence on the dose-distribution, irradiated site and time from start of treatmentInt J Radiat Biol2007836396510.1080/0955300070159611817729159Open DOISearch in Google Scholar
Mariotti LG, Pirovano G, Savage KI, Ghita M, Ottolenghi A, Prise KM, et al. Use of the γ-H2AX Assay to Investigate DNA repair dynamics following multiple radiation exposures. PLOS One 2013; 8: 1-12. doi: 10.1371/journal.pone.0079541MariottiLGPirovanoGSavageKIGhitaMOttolenghiAPriseKMet alUse of the γ-H2AX Assay to Investigate DNA repair dynamics following multiple radiation exposuresPLOS One2013811210.1371/journal.pone.0079541384365724312182Open DOISearch in Google Scholar
Bouquet F, Muller C, Salles B. The loss of gH2AX signal is a marker of DNA double strand breaks repair only at low levels of DNA damage. Cell Cycle 2006; 5: 1116-22. doi: 10.4161/cc.5.10.2799BouquetFMullerCSallesBThe loss of gH2AX signal is a marker of DNA double strand breaks repair only at low levels of DNA damageCell Cycle2006511162210.4161/cc.5.10.279916721046Open DOISearch in Google Scholar
Werbrouck J, De Ruyck K, Beels L, Vraal A, Van Eijkeren M, De Neve W, et al. Prediction of late normal tissue complications in RT treated gynaecological cancer patients: potential of the γ-H2AX foci. Oncol Rep 2010; 23: 571-8. doi: 10.3892/or_00000671WerbrouckJDe RuyckKBeelsLVraalAVanEijkeren MDe NeveWet alPrediction of late normal tissue complications in RT treated gynaecological cancer patients: potential of the γ-H2AX fociOncol Rep201023571810.3892/or_00000671Open DOISearch in Google Scholar
