A multi-institutional analysis of diffuse large B-cell lymphoma (DLBCL) treated with consolidative radiotherapy and the impact of cell-of-origin on outcomes
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Tilly H, Gomes da Silva M, Vitolo U, Jack A, Meignan M, Lopez-Guillermo A, et al. Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2015; 26(Suppl 5): v116-25. doi: 10.1093/annonc/mdv304TillyHGomesda Silva MVitoloUJackAMeignanMLopez-GuillermoADiffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upAnn Oncol201526Suppl 5v1162510.1093/annonc/mdv304Open DOISearch in Google Scholar
Fisher RI, Miller TP, O’Connor OA. Diffuse aggressive lymphoma. Hematology Am Soc Hematol Educ Program 2004; 221-36. doi: 10.1182/asheducation-2004.1.221FisherRIMillerTPO’ConnorOADiffuse aggressive lymphomaHematology Am Soc Hematol Educ Program20042213610.1182/asheducation-2004.1.221Open DOISearch in Google Scholar
Bush RS, Gospodarowicz M, Sturgeon J, Alison R. Radiation therapy of localized non-Hodgkin’s lymphoma. Cancer Treat Rep 1977; 61: 1129-36. PMID: 332347BushRSGospodarowiczMSturgeonJAlisonRRadiation therapy of localized non-Hodgkin’s lymphomaCancer Treat Rep197761112936PMID: 332347Search in Google Scholar
Haque W, Dabaja B, Tann A, Khan M, Szeja S, Butler EB, et al. Changes in treatment patterns and impact of radiotherapy for early stage diffuse large B cell lymphoma after rituximab: a population-based analysis. Radiother Oncol 2016; 120: 150-5. doi: 10.1016/j.radonc.2016.05.027HaqueWDabajaBTannAKhanMSzejaSButlerEBChanges in treatment patterns and impact of radiotherapy for early stage diffuse large B cell lymphoma after rituximab: a population-based analysisRadiother Oncol2016120150510.1016/j.radonc.2016.05.027Open DOISearch in Google Scholar
Vargo JA, Gill BS, Balasubramani GK, Beriwal S. Treatment selection and survival outcomes in early-stage diffuse large B-cell lymphoma: do we still need consolidative radiotherapy? J Clin Oncol 2015; 33: 3710-7. doi: 10.1200/JCO.2015.61.7654VargoJAGillBSBalasubramaniGKBeriwalSTreatment selection and survival outcomes in early-stage diffuse large B-cell lymphoma: do we still need consolidative radiotherapy?J Clin Oncol2015333710710.1200/JCO.2015.61.7654Open DOISearch in Google Scholar
Coiffier B, Lepage E, Briere J, Herbrecht R, Tilly H, Bouabdallah R, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002; 346: 235-42. doi: 10.1056/NEJMoa011795CoiffierBLepageEBriereJHerbrechtRTillyHBouabdallahRCHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphomaN Engl J Med20023462354210.1056/NEJMoa011795Open DOISearch in Google Scholar
Pfreundschuh M, Kuhnt E, Trumper L, Osterborg A, Trneny M, Shepherd L, et al. CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group. Lancet Oncol 2011; 12: 1013-22. doi: 10.1016/S1470-2045(11)70235-2PfreundschuhMKuhntETrumperLOsterborgATrnenyMShepherdLCHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) GroupLancet Oncol20111210132210.1016/S1470-2045(11)70235-2Open DOISearch in Google Scholar
Phan J, Mazloom A, Medeiros LJ, Zreik TG, Wogan C, Shihadeh F, et al. Benefit of consolidative radiation therapy in patients with diffuse large B-cell lymphoma treated with R-CHOP chemotherapy. J Clin Oncol 2010; 28: 4170-6. doi: 10.1200/JCO.2009.27.3441PhanJMazloomAMedeirosLJZreikTGWoganCShihadehFBenefit of consolidative radiation therapy in patients with diffuse large B-cell lymphoma treated with R-CHOP chemotherapyJ Clin Oncol2010284170610.1200/JCO.2009.27.344120713859Open DOISearch in Google Scholar
Held G, Murawski N, Ziepert M, Fleckenstein J, Poschel V, Zwick C, et al. Role of radiotherapy to bulky disease in elderly patients with aggressive B-cell lymphoma. J Clin Oncol 2014; 32: 1112-8. doi: 10.1200/JCO.2013.51.4505HeldGMurawskiNZiepertMFleckensteinJPoschelVZwickCRole of radiotherapy to bulky disease in elderly patients with aggressive B-cell lymphomaJ Clin Oncol2014321112810.1200/JCO.2013.51.450524493716Open DOISearch in Google Scholar
Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med 2018; 24: 679-90. doi: 10.1038/s41591-018-0016-8ChapuyBStewartCDunfordAJKimJKamburovAReddRAMolecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomesNat Med2018246799010.1038/s41591-018-0016-8661338729713087Open DOISearch in Google Scholar
Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503-11. doi: 10.1038/35000501AlizadehAAEisenMBDavisREMaCLossosISRosenwaldADistinct types of diffuse large B-cell lymphoma identified by gene expression profilingNature20004035031110.1038/3500050110676951Open DOISearch in Google Scholar
Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 2004; 103: 275-82. doi: 10.1182/blood-2003-05-1545HansCPWeisenburgerDDGreinerTCGascoyneRDDelabieJOttGConfirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarrayBlood20041032758210.1182/blood-2003-05-154514504078Open DOISearch in Google Scholar
Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, et al. Stromal gene signatures in large-B-cell lymphomas. N Engl J Med 2008; 359: 2313-23. doi: 10.1056/NEJMoa0802885LenzGWrightGDaveSSXiaoWPowellJZhaoHStromal gene signatures in large-B-cell lymphomasN Engl J Med200835923132310.1056/NEJMoa0802885910371319038878Open DOISearch in Google Scholar
Chong VC, Yap ES, Xin L, Chin ST, Jeyasekharan A, Chee Y-L, et al. Immunophenotypic and genetic characteristics of diffuse large B-cell lymphoma (DLBCL), and prognostic significance of cell of origin (COO) in a southeast Asian cohort. Blood 2018; 132(Suppl 1): 4222. doi: 10.1182/blood-2018-99-119672ChongVCYapESXinLChinSTJeyasekharanACheeY-LImmunophenotypic and genetic characteristics of diffuse large B-cell lymphoma (DLBCL), and prognostic significance of cell of origin (COO) in a southeast Asian cohortBlood2018132Suppl 1422210.1182/blood-2018-99-119672Open DOISearch in Google Scholar
International Non-Hodgkin’s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med 1993; 329: 987-94. doi: 10.1056/NEJM199309303291402International Non-Hodgkin’s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin’s lymphomaN Engl J Med19933299879410.1056/NEJM1993093032914028141877Open DOISearch in Google Scholar
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 2014; 32: 3059-68. doi: 10.1200/JCO.2013.54.8800ChesonBDFisherRIBarringtonSFCavalliFSchwartzLHZuccaERecommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classificationJ Clin Oncol20143230596810.1200/JCO.2013.54.8800497908325113753Open DOISearch in Google Scholar
Yahalom J, Mauch P. The involved field is back: issues in delineating the radiation field in Hodgkin’s disease. Ann Oncol 2002; 13(Suppl 1): 79-83. doi: 10.1093/annonc/13.s1.79YahalomJMauchPThe involved field is back: issues in delineating the radiation field in Hodgkin’s diseaseAnn Oncol200213Suppl 1798310.1093/annonc/13.s1.7912078908Open DOISearch in Google Scholar
Illidge T, Specht L, Yahalom J, Aleman B, Berthelsen AK, Constine L, et al. Modern radiation therapy for nodal non-Hodgkin lymphoma-target definition and dose guidelines from the International Lymphoma Radiation Oncology Group. Int J Radiat Oncol Biol Phys 2014; 89: 49-58. doi: 10.1016/j. ijrobp.2014.01.006IllidgeTSpechtLYahalomJAlemanBBerthelsenAKConstineLModern radiation therapy for nodal non-Hodgkin lymphoma-target definition and dose guidelines from the International Lymphoma Radiation Oncology GroupInt J Radiat Oncol Biol Phys201489495810.1016/j.ijrobp.2014.01.00624725689Open DOISearch in Google Scholar
Specht L. Does radiation have a role in advanced stage Hodgkin’s or Non-Hodgkin lymphoma? Curr Treat Options Oncol 2016; 17: 4. doi: 10.1007/s11864-015-0377-xSpechtLDoes radiation have a role in advanced stage Hodgkin’s or Non-Hodgkin lymphoma?Curr Treat Options Oncol201617410.1007/s11864-015-0377-x26739151Open DOISearch in Google Scholar
Horning SJ, Weller E, Kim K, Earle JD, O’Connell MJ, Habermann TM, et al. Chemotherapy with or without radiotherapy in limited-stage diffuse aggressive non-Hodgkin’s lymphoma: Eastern Cooperative Oncology Group study 1484. J Clin Oncol 2004; 22: 3032-8. doi: 10.1200/JCO.2004.06.088HorningSJWellerEKimKEarleJDO’ConnellMJHabermannTMChemotherapy with or without radiotherapy in limited-stage diffuse aggressive non-Hodgkin’s lymphoma: Eastern Cooperative Oncology Group study 1484J Clin Oncol2004223032810.1200/JCO.2004.06.08815210738Open DOISearch in Google Scholar
Reyes F, Lepage E, Ganem G, Molina TJ, Brice P, Coiffier B, et al. ACVBP versus CHOP plus radiotherapy for localized aggressive lymphoma. N Engl J Med 2005; 352: 1197-205. doi: 10.1056/NEJMoa042040ReyesFLepageEGanemGMolinaTJBricePCoiffierBACVBP versus CHOP plus radiotherapy for localized aggressive lymphomaN Engl J Med2005352119720510.1056/NEJMoa04204015788496Open DOISearch in Google Scholar
Bonnet C, Fillet G, Mounier N, Ganem G, Molina TJ, Thieblemont C, et al. CHOP alone compared with CHOP plus radiotherapy for localized aggressive lymphoma in elderly patients: a study by the Groupe d’Etude des Lymphomes de l’Adulte. J Clin Oncol 2007; 25: 787-92. doi: 10.1200/JCO.2006.07.0722BonnetCFilletGMounierNGanemGMolinaTJThieblemontCCHOP alone compared with CHOP plus radiotherapy for localized aggressive lymphoma in elderly patients: a study by the Groupe d’Etude des Lymphomes de l’AdulteJ Clin Oncol2007257879210.1200/JCO.2006.07.072217228021Open DOISearch in Google Scholar
Aviles A, Nambo MJ, Calva A, Neri N, Cleto S, Silva L. Adjuvant radiotherapy in patients with diffuse large B-cell lymphoma in advanced stage (III/IV) improves the outcome in the rituximab era. Hematology 2018; 1-5. doi: 10.1080/10245332.2018.1423880AvilesANamboMJCalvaANeriNCletoSSilvaLAdjuvant radiotherapy in patients with diffuse large B-cell lymphoma in advanced stage (III/IV) improves the outcome in the rituximab eraHematology20181510.1080/10245332.2018.142388029338665Open DOISearch in Google Scholar
Lamy T, Damaj G, Soubeyran P, Gyan E, Cartron G, Bouabdallah K, et al. R-CHOP 14 with or without radiotherapy in nonbulky limited-stage diffuse large B-cell lymphoma. Blood 2018; 131: 174-81. doi: 10.1182/blood-2017-07-793984LamyTDamajGSoubeyranPGyanECartronGBouabdallahKR-CHOP 14 with or without radiotherapy in nonbulky limited-stage diffuse large B-cell lymphomaBlood20181311748110.1182/blood-2017-07-793984575768029061568Open DOISearch in Google Scholar
Pfreundschuh M, Murawski N, Ziepert M, Altmann B, Dreyling MH, Borchmann P, et al. Radiotherapy (RT) to bulky (B) and extralymphatic (E) disease in combination with 6xR-CHOP-14 or R-CHOP-21 in young good-prognosis DLBCL patients: Results of the 2x2 randomized UNFOLDER trial of the DSHNHL/GLA. J Clin Oncol 2018; 36(15 Suppl): 7574. doi: 10.1200/JCO.2018.36.15_suppl.7574.PfreundschuhMMurawskiNZiepertMAltmannBDreylingMHBorchmannPRadiotherapy (RT) to bulky (B) and extralymphatic (E) disease in combination with 6xR-CHOP-14 or R-CHOP-21 in young good-prognosis DLBCL patients: Results of the 2x2 randomized UNFOLDER trial of the DSHNHL/GLAJ Clin Oncol20183615 Suppl757410.1200/JCO.2018.36.15_suppl.7574Open DOISearch in Google Scholar
Shi Z, Das S, Okwan-Duodu D, Esiashvili N, Flowers C, Chen Z, et al. Patterns of failure in advanced stage diffuse large B-cell lymphoma patients after complete response to R-CHOP immunochemotherapy and the emerging role of consolidative radiation therapy. Int J Radiat Oncol Biol Phys 2013; 86: 569-77. doi: 10.1016/j.ijrobp.2013.02.007ShiZDasSOkwan-DuoduDEsiashviliNFlowersCChenZPatterns of failure in advanced stage diffuse large B-cell lymphoma patients after complete response to R-CHOP immunochemotherapy and the emerging role of consolidative radiation therapyInt J Radiat Oncol Biol Phys2013865697710.1016/j.ijrobp.2013.02.00723540349Open DOISearch in Google Scholar
Fridrik MA. ASCO update on lymphoma. Memo 2017; 10: 218-9. doi: 10.1007/s12254-017-0372-yFridrikMAASCO update on lymphomaMemo201710218910.1007/s12254-017-0372-y572551129250199Open DOISearch in Google Scholar
Issa DE, van de Schans SA, Chamuleau ME, Karim-Kos HE, Wondergem M, Huijgens PC, et al. Trends in incidence, treatment and survival of aggressive B-cell lymphoma in the Netherlands 1989-2010. Haematologica 2015; 100: 525-33. doi: 10.3324/haematol.2014.107300IssaDEvan deSchans SAChamuleauMEKarim-KosHEWondergemMHuijgensPCTrends in incidence, treatment and survival of aggressive B-cell lymphoma in the Netherlands 1989-2010Haematologica20151005253310.3324/haematol.2014.107300438072625512643Open DOISearch in Google Scholar
