The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma
, , , and | Mar 14, 2019
About this article
Article Category: Research Article
Published Online: Mar 14, 2019
Page range: 206 - 212
Received: Feb 06, 2019
Accepted: Feb 25, 2019
DOI: https://doi.org/10.2478/raon-2019-0016
© 2019 Kristina Levpuscek, Katja Goricar, Viljem Kovac, Vita Dolzan, Alenka Franko, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
The influence of polymorphisms on MM risk
| Polymorphism | Genotype | MM patients | Controls | Unadjusted risk | Adjusted risk by gender and age | |||
|---|---|---|---|---|---|---|---|---|
| N (%) | N (%) | OR (95% CI) | p | OR (95% CI) | p | |||
| TT | 97 (41.8)1 | 64 (35.8)2 | ||||||
| TC | 94 (40.5) | 87 (48.6) | 0.78 | 0.69 | ||||
| CC | 41 (17.7) | 28 (15.6) | (0.52–1.16) | 0.213 | (0.45–1.06) | 0.091 | ||
| GG | 142 (59.9) | 84 (47.7)3 | ||||||
| GT | 77 (32.5) | 75 (42.6) | 0.61 | 0.52 | ||||
| TT | 18 (7.6) | 17 (9.7) | (0.41–0.91) | (0.34–0.80) | ||||
| CC | 196 (86.0)4 | 171 (90.0)5 | 1.47 | 1.12 | ||||
| CT | 32 (14.0) | 19 (10.0) | (0.80–2.69) | 0.211 | (0.58–2.16) | 0.728 | ||
| CC | 90 (38.0) | 74 (42.8)6 | ||||||
| CT | 125 (52.7) | 79 (45.7) | 1.22 | 1.03 | ||||
| TT | 22 (9.3) | 20 (11.6) | (0.82–1.82) | 0.327 | (0.67–1.59) | 0.890 |
The influence of interactions between the investigated polymorphisms and asbestos exposure on MM risk
| Polymorphism | OR | 95% CI | p |
|---|---|---|---|
| 1.93 | 0.61–6.10 | 0.262 | |
| 1.85 | 0.33–10.48 | 0.489 | |
| 2.80 | 0.89–8.79 | 0.078 |
Characteristics of malignant mesothelioma (MM) patients, controls and the influence of these characteristics on MM risk
| MM | patients (n = 237) | Controls (n = 193) | Test | OR (95% CI) | p | |
|---|---|---|---|---|---|---|
| Male n (%) | 175 (73.8%) | 128 (66.3%) | χ2 = 2.889 | 0.70 | 0.089 | |
| Female n (%) | 62 (26.2%) | 65 (33.7%) | (0.46–1.06) | |||
| Years; median (25–75%) | 66 (58–72) | 56.2 (49.3–65.0) | U = 32583 | 1.08 (0.46–1.06) | < 0.001 | |
| Low | 36 (44.4%) | 149 (77.2%) | χ2 = 31.933 | |||
| Medium | 24 (29.6%) | 15 (7.8%) | ||||
| High | 21 (25.9%) | 29 (15.0%) | ||||
| Low | 36 (44.4%) | 149 (77.2%) | χ2 = 27.916 | 4.233 | ||
| Medium and high | 45 (55.6) | 44 (22.8%) | (2.44–7.36) | |||
| No | 122 (53.0%) | 106 (54.9%) | χ2 = 0.149 | 1.08 | 0.699 | |
| Yes | 108 (47.0%) | 87 (45.1%) | (0.74–1.58) |
The influence of interaction between ERCC1 rs11615 polymorphism and asbestos exposure on MM risk
| Asbestos exposure | OR for asbestos exposure inside category | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Low | Medium and high | |||||||||
| MM (N) | Controls (N) | OR (95% CI) | p | MM (N) | Controls (N) | OR (95% CI) | p | OR (95% CI) | p | |
| 20 | 48 | 1 | Ref. | 14 | 16 | 2.10 (0.872.10 –5.10) | 0.101 | 2.10 (0.872.10 –5.10) | 0.101 | |
| 15 | 91 | 0.40 (0.190.40 –0.84) | 0.016 | 30 | 24 | 3.00 (1.423.00 –6.34) | 0.004 | 7.58 (3.537.58 –16.31) | < 0.001 | |
| 0.40 (0.19–0.84) | 0.016 | 1.43 (0.58–4.50) | 0.435 | |||||||
The influence of interactions between investigated genetic polymorphisms on MM risk
| Gene 1 | Gene 2 | Interaction | |||||
|---|---|---|---|---|---|---|---|
| 0.78 | 0.61 | 1.971 | |||||
| TC + CC vs. TT | (0.52–1.16) | 0.213 | GT + TT vs. GG | (0.41–0.91) | 0.014 | (0.42–9.17) | 0.75 |
| 0.78 | 1.47 | 1.302 | |||||
| TC + CC vs. TT | (0.52–1.16) | 0.213 | CT vs. CC | (0.80–2.69) | 0.211 | (0.37–4.52) | 0.680 |
| 0.78 | 1.22 | 0.793 | |||||
| TC + CC vs. TT | (0.52–1.16) | 0.213 | CT + TT vs. CC | (0.82–1.82) | 0.327 | (0.34–1.86) | 0.592 |
| 0.61 | 1.47 | 1.494 | |||||
| GT + TT vs. GG | (0.41–0.91) | 0.014 | CT vs. CC | (0.80–2.69) | 0.211 | (0.42–5.21) | 0.537 |
| 0.61 | 1.22 | 0.655 | |||||
| GT + TT vs. GG | (0.41–0.91) | 0.014 | CT + TT vs. CC | (0.82–1.82) | 0.327 | (0.29–1.47) | 0.302 |
| 1.47 | 1.22 | 2.416 | |||||
| CT vs. CC | (0.80–2.69) | 0.211 | CT + TT vs. CC | (0.82–1.82) | 0.327 | (0.66–8.80) | 0.182 |