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Dendritic cell profiles in the inflamed colonic mucosa predict the responses to tumor necrosis factor alpha inhibitors in inflammatory bowel disease


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Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev 2014; 13: 3-10. doi: 10.1016/j.autrev.2013.06.004GeremiaABiancheriPAllanPCorazzaGRDi SabatinoA.Innate and adaptive immunity in inflammatory bowel diseaseAutoimmun Rev20141331010.1016/j.autrev.2013.06.00423774107Open DOISearch in Google Scholar

Kmiec Z, Cyman M, Slebioda TJ. Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease. Adv Med Sci 2017; 62: 1-16. doi: 10.1016/j.advms.2016.09.001KmiecZCymanMSlebiodaTJCells of the innate and adaptive immunity and their interactions in inflammatory bowel diseaseAdv Med Sci20176211610.1016/j.advms.2016.09.00128126697Open DOISearch in Google Scholar

Niess JH. Role of mucosal dendritic cells in inflammatory bowel disease. World J Gastroenterol 2008; 14: 5138-48. doi: 10.3748/wjg.14.5138NiessJHRole of mucosal dendritic cells in inflammatory bowel diseaseWorld J Gastroenterol20081451384810.3748/wjg.14.5138274400318777590Open DOISearch in Google Scholar

Rutella S, Locatelli F. Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease. World J Gastroenterol 2011; 17: 3761-75. doi: 10.3748/wjg.v17.i33.3761RutellaSLocatelliFIntestinal dendritic cells in the pathogenesis of inflammatory bowel diseaseWorld J Gastroenterol20111737617510.3748/wjg.v17.i33.3761318143721987618Open DOISearch in Google Scholar

Cader MZ, Kaser A. Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut 2013; 62: 1653-64. doi: 10.1136/gutjnl-2012-303955CaderMZKaserARecent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammationGut20136216536410.1136/gutjnl-2012-30395524104886Open DOISearch in Google Scholar

Kushwah R, Hu J. Complexity of dendritic cell subsets and their function in the host immune system. Immunology 2011; 133: 409-19. doi: 10.1111/j.1365-2567.2011.03457.xKushwahRHuJComplexity of dendritic cell subsets and their function in the host immune systemImmunology20111334091910.1111/j.1365-2567.2011.03457.x314335221627652Open DOISearch in Google Scholar

Alloatti A, Kotsias F, Magalhaes JG, Amigorena S. Dendritic cell maturation and cross-presentation: timing matters! Immunol Rev 2016; 272: 97-108. doi: 10.1111/imr.12432AlloattiAKotsiasFMagalhaesJGAmigorenaSDendritic cell maturation and cross-presentation: timing matters!Immunol Rev20162729710810.1111/imr.12432668031327319345Open DOISearch in Google Scholar

Stockwin LH, McGonagle D, Martin IG, Blair GE. Dendritic cells: immunological sentinels with a central role in health and disease. Immunol Cell Biol 2000; 78: 91-102. doi: 10.1046/j.1440-1711.2000.00888.xStockwinLHMcGonagleDMartinIGBlairGEDendritic cells: immunological sentinels with a central role in health and diseaseImmunol Cell Biol2000789110210.1046/j.1440-1711.2000.00888.x715938310762408Open DOISearch in Google Scholar

Abbas A, Lichtman A, Pillai S. Basic immunology: functions and disorders of the immune system. 5th Edition. St. Louis, Missouri: Elsevier; 2015.AbbasALichtmanAPillaiSBasic immunology: functions and disorders of the immune system5th EditionSt. Louis, MissouriElsevier2015Search in Google Scholar

Sallusto F, Lanzavecchia A. The instructive role of dendritic cells on T-cell responses. Arthritis Res 2002; 4: S127-32. doi: 10.1186/ar567SallustoFLanzavecchiaAThe instructive role of dendritic cells on T-cell responsesArthritis Res20024S1273210.1186/ar567324014312110131Open DOISearch in Google Scholar

Blanco P, Palucka AK, Pascual V, Banchereau J. Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev 2008; 19: 41-52. doi: 10.1016/j.cytogfr.2007.10.004BlancoPPaluckaAKPascualVBanchereauJDendritic cells and cytokines in human inflammatory and autoimmune diseasesCytokine Growth Factor Rev200819415210.1016/j.cytogfr.2007.10.004241306818258476Open DOISearch in Google Scholar

Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: the role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol 2016; 22: 4794-801. doi: 10.3748/wjg.v22.i20.4794AxelradJELichtigerSYajnikVInflammatory bowel disease and cancer: the role of inflammation, immunosuppression, and cancer treatmentWorld J Gastroenterol201622479480110.3748/wjg.v22.i20.4794487387227239106Open DOISearch in Google Scholar

Coombes JL, Powrie F. Dendritic cells in intestinal immune regulation. Nat Rev Immunol 2008; 8: 435-46. doi: 10.1038/nri2335CoombesJLPowrieFDendritic cells in intestinal immune regulationNat Rev Immunol200884354610.1038/nri2335267420818500229Open DOISearch in Google Scholar

Choy MC, Visvanathan K, De Cruz P. An overview of the innate and adaptive immune system in inflammatory bowel disease. Inflamm Bowel Dis 2017; 23: 2-13. doi: 10.1097/mib.0000000000000955ChoyMCVisvanathanKDe CruzPAn overview of the innate and adaptive immune system in inflammatory bowel diseaseInflamm Bowel Dis20172321310.1097/mib.000000000000095527779499Open DOISearch in Google Scholar

Persson EK, Scott CL, Mowat AM, Agace WW. Dendritic cell subsets in the intestinal lamina propria: ontogeny and function. Eur J Immunol 2013; 43: 3098-107. doi: 10.1002/eji.201343740PerssonEKScottCLMowatAMAgaceWWDendritic cell subsets in the intestinal lamina propria: ontogeny and functionEur J Immunol201343309810710.1002/eji.201343740393373323966272Open DOISearch in Google Scholar

Schiavi E, Smolinska S, O’Mahony L. Intestinal dendritic cells. Curr Opin Gastroenterol 2015; 31: 98-103. doi: 10.1097/mog.0000000000000155SchiaviESmolinskaSO’MahonyLIntestinal dendritic cellsCurr Opin Gastroenterol2015319810310.1097/mog.0000000000000155Open DOISearch in Google Scholar

Vitale S, Strisciuglio C, Pisapia L, Miele E, Barba P, Vitale A, et al. Cytokine production profile in intestinal mucosa of paediatric inflammatory bowel disease. PLoS One 2017; 12: e0182313. doi: 10.1371/journal.pone.0182313VitaleSStrisciuglioCPisapiaLMieleEBarbaPVitaleAet alCytokine production profile in intestinal mucosa of paediatric inflammatory bowel diseasePLoS One201712e018231310.1371/journal.pone.0182313555223028797042Open DOISearch in Google Scholar

Baumgart DC, Metzke D, Schmitz J, Scheffold A, Sturm A, Wiedenmann B, et al. Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells. Gut 2005; 54: 228-36. doi: 10.1136/gut.2004.040360BaumgartDCMetzkeDSchmitzJScheffoldASturmAWiedenmannBet alPatients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cellsGut2005542283610.1136/gut.2004.040360177484415647187Open DOISearch in Google Scholar

Middel P, Raddatz D, Gunawan B, Haller F, Radzun HJ. Increased number of mature dendritic cells in Crohn’s disease: evidence for a chemokine mediated retention mechanism. Gut 2006; 55: 220-7. doi: 10.1136/ gut.2004.063008MiddelPRaddatzDGunawanBHallerFRadzunHJIncreased number of mature dendritic cells in Crohn’s disease: evidence for a chemokine mediated retention mechanismGut200655220710.1136/gut.2004.063008185649416118351Open DOISearch in Google Scholar

Baumgart DC, Metzke D, Guckelberger O, Pascher A, Grotzinger C, Przesdzing I, et al. Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn’s disease and ulcerative colitis. Clin Exp Immunol 2011; 166: 46-54. doi: 10.1111/j.1365-2249.2011.04439.xBaumgartDCMetzkeDGuckelbergerOPascherAGrotzingerCPrzesdzingIet alAberrant plasmacytoid dendritic cell distribution and function in patients with Crohn’s disease and ulcerative colitisClin Exp Immunol2011166465410.1111/j.1365-2249.2011.04439.x319391821762123Open DOISearch in Google Scholar

Sanchez-Munoz F, Dominguez-Lopez A, Yamamoto-Furusho JK. Role of cytokines in inflammatory bowel disease. World J Gastroenterol 2008; 14: 4280-8. doi: 10.3748/wjg.14.4280Sanchez-MunozFDominguez-LopezAYamamoto-FurushoJKRole of cytokines in inflammatory bowel diseaseWorld J Gastroenterol2008144280810.3748/wjg.14.4280273117718666314Open DOISearch in Google Scholar

Van Deventer SJ. Tumour necrosis factor and Crohn’s disease. Gut 1997; 40: 443-8. doi: 10.1136/gut.40.4.443Van DeventerSJTumour necrosis factor and Crohn’s diseaseGut199740443810.1136/gut.40.4.44310271159176068Open DOISearch in Google Scholar

Sands BE, Kaplan GG. The role of TNFalpha in ulcerative colitis. J Clin Pharmacol 2007; 47: 930-41. doi: 10.1177/0091270007301623SandsBEKaplanGGThe role of TNFalpha in ulcerative colitisJ Clin Pharmacol2007479304110.1177/009127000730162317567930Open DOISearch in Google Scholar

Levin AD, Wildenberg ME, van den Brink GR. Mechanism of action of anti-TNF therapy in inflammatory bowel disease. J Crohns Colitis 2016; 10: 989-97. doi: 10.1093/ecco-jcc/jjw053LevinADWildenbergMEvan den BrinkGRMechanism of action of anti-TNF therapy in inflammatory bowel diseaseJ Crohns Colitis2016109899710.1093/ecco-jcc/jjw05326896086Open DOISearch in Google Scholar

Nielsen OH, Ainsworth MA. Tumor necrosis factor inhibitors for inflammatory bowel disease. N Engl J Med 2013; 369: 754-62. doi: 10.1056/NEJMct1209614NielsenOHAinsworthMATumor necrosis factor inhibitors for inflammatory bowel diseaseN Engl J Med20133697546210.1056/NEJMct120961423964937Open DOISearch in Google Scholar

Chapman CG, Rubin DT. The potential for medical therapy to reduce the risk of colorectal cancer and optimize surveillance in inflammatory bowel disease. Gastrointest Endosc Clin N Am 2014; 24: 353-65. doi: 10.1016/j. giec.2014.03.008ChapmanCGRubinDTThe potential for medical therapy to reduce the risk of colorectal cancer and optimize surveillance in inflammatory bowel diseaseGastrointest Endosc Clin N Am2014243536510.1016/j.giec.2014.03.008416543024975527Open DOISearch in Google Scholar

Andersen NN, Jess T. Has the risk of colorectal cancer in inflammatory bowel disease decreased? World J Gastroenterol 2013; 19: 7561-8. doi: 10.3748/wjg.v19.i43.7561AndersenNNJessTHas the risk of colorectal cancer in inflammatory bowel disease decreased?World J Gastroenterol2013197561810.3748/wjg.v19.i43.7561383725424282346Open DOISearch in Google Scholar

Kopylov U, Seidman E. Predicting durable response or resistance to antitumor necrosis factor therapy in inflammatory bowel disease. Therap Adv Gastroenterol 2016; 9: 513-26. doi: 10.1177/1756283x16638833KopylovUSeidmanEPredicting durable response or resistance to antitumor necrosis factor therapy in inflammatory bowel diseaseTherap Adv Gastroenterol201695132610.1177/1756283x16638833Open DOISearch in Google Scholar

Gomollon F, Dignass A, Annese V, Tilg H, Van Assche G, Lindsay JO, et al. 3rd European evidence-based consensus on the diagnosis and management of Crohn’s disease 2016: part 1: diagnosis and medical management. J Crohns Colitis 2017; 11: 3-25. doi: 10.1093/ecco-jcc/jjw168GomollonFDignassAAnneseVTilgHVanAssche GLindsayJOet al3rd European evidence-based consensus on the diagnosis and management of Crohn’s disease 2016: part 1: diagnosis and medical managementJ Crohns Colitis20171132510.1093/ecco-jcc/jjw16827660341Open DOISearch in Google Scholar

Magro F, Gionchetti P, Eliakim R, Ardizzone S, Armuzzi A, Acosta MB, et al. Third european evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders. J Crohns Colitis 2017; 11: 649-70. doi: 10.1093/ecco-jcc/jjx008MagroFGionchettiPEliakimRArdizzoneSArmuzziAAcostaMBet alThird european evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disordersJ Crohns Colitis2017116497010.1093/ecco-jcc/jjx00828158501Open DOISearch in Google Scholar

Best WR. Predicting the Crohn’s disease activity index from the Harvey-Bradshaw Index. Inflamm Bowel Dis 2006; 12: 304-10. doi: 10.1097/01. MIB.0000215091.77492.2aBestWRPredicting the Crohn’s disease activity index from the Harvey-Bradshaw IndexInflamm Bowel Dis2006123041010.1097/01.MIB.0000215091.77492.2a16633052Open DOISearch in Google Scholar

Walmsley RS, Ayres RC, Pounder RE, Allan RN. A simple clinical colitis activity index. Gut 1998; 43: 29-32. doi: 10.1136/gut.43.1.29WalmsleyRSAyresRCPounderREAllanRNA simple clinical colitis activity indexGut199843293210.1136/gut.43.1.29Open DOISearch in Google Scholar

Daperno M, D’Haens G, Van Assche G, Baert F, Bulois P, Maunoury V, et al. Development and validation of a new, simplified endoscopic activity score for Crohn’s disease: the SES-CD. Gastrointest Endosc 2004; 60: 505-12. doi: 10.1016/S0016-5107(04)01878-4DapernoMD’HaensGVanAssche GBaertFBuloisPMaunouryVet alDevelopment and validation of a new, simplified endoscopic activity score for Crohn’s disease: the SES-CDGastrointest Endosc2004605051210.1016/S0016-5107(04)01878-4Open DOISearch in Google Scholar

Buchner AM, Lichtenstein GR. How to assess and document endoscopies in IBD patients by including standard scoring systems. Inflamm Bowel Dis 2016; 22: 1010-9. doi: 10.1097/mib.0000000000000649BuchnerAMLichtensteinGRHow to assess and document endoscopies in IBD patients by including standard scoring systemsInflamm Bowel Dis2016221010910.1097/mib.0000000000000649Open DOISearch in Google Scholar

Côté-Daigneault J, Bouin M, Lahaie R, Colombel JF, Poitras P. Biologics in inflammatory bowel disease: what are the data? United Eur Gastroenterol J 2015; 3: 419-28. doi: 10.1177/2050640615590302Côté-DaigneaultJBouinMLahaieRColombelJFPoitrasPBiologics in inflammatory bowel disease: what are the data?United Eur Gastroenterol J201534192810.1177/2050640615590302462575126535119Open DOISearch in Google Scholar

Scott CL, Wright PB, Milling SW, Mowat AM. Isolation and identification of conventional dendritic cell subsets from the intestine of mice and men. Methods Mol Biol 2016; 1423: 101-18. doi: 10.1007/978-1-4939-3606-9_7ScottCLWrightPBMillingSWMowatAMIsolation and identification of conventional dendritic cell subsets from the intestine of mice and menMethods Mol Biol201614231011810.1007/978-1-4939-3606-9_727142011Open DOISearch in Google Scholar

Roe MM, Swain S, Sebrell TA, Sewell MA, Collins MM, Perrino BA, et al. Differential regulation of CD103 (alphaE integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands. J Leukoc Biol 2017; 101: 1169-80. doi: 10.1189/jlb.1MA0316-131RRoeMMSwainSSebrellTASewellMACollinsMMPerrinoBAet alDifferential regulation of CD103 (alphaE integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligandsJ Leukoc Biol201710111698010.1189/jlb.1MA0316-131R538037828087652Open DOISearch in Google Scholar

Dige A, Magnusson MK, Ohman L, Hvas CL, Kelsen J, Wick MJ, et al. Reduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-alpha treatment in patients with Crohn’s disease. Scand J Gastroenterol 2016; 51: 692-9. doi: 10.3109/00365521.2015.1134649DigeAMagnussonMKOhmanLHvasCLKelsenJWickMJet alReduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-alpha treatment in patients with Crohn’s diseaseScand J Gastroenterol201651692910.3109/00365521.2015.113464926784676Open DOISearch in Google Scholar

Zampeli E, Gizis M, Siakavellas SI, Bamias G. Predictors of response to anti-tumor necrosis factor therapy in ulcerative colitis. World J Gastrointest Pathophysiol 2014; 5: 293-303. doi: 10.4291/wjgp.v5.i3.293ZampeliEGizisMSiakavellasSIBamiasGPredictors of response to anti-tumor necrosis factor therapy in ulcerative colitisWorld J Gastrointest Pathophysiol2014529330310.4291/wjgp.v5.i3.293413352725133030Open DOISearch in Google Scholar

Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, Lang Y, Friedman JR, et al. Ustekinumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med 2016; 375: 1946-60. doi: 10.1056/NEJMoa1602773FeaganBGSandbornWJGasinkCJacobsteinDLangYFriedmanJRet alUstekinumab as induction and maintenance therapy for Crohn’s diseaseN Engl J Med201637519466010.1056/NEJMoa160277327959607Open DOISearch in Google Scholar

McLean LP, Shea-Donohue T, Cross RK. Vedolizumab for the treatment of ulcerative colitis and Crohn’s disease. Immunotherapy 2012; 4: 883-98. doi: 10.2217/imt.12.85McLeanLPShea-Donohue TCrossRKVedolizumab for the treatment of ulcerative colitis and Crohn’s diseaseImmunotherapy201248839810.2217/imt.12.85355791723046232Open DOISearch in Google Scholar

Colombel JF, Rutgeerts P, Reinisch W, Esser D, Wang Y, Lang Y, et al. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011; 141: 1194-201. doi: 10.1053/j.gastro.2011.06.054ColombelJFRutgeertsPReinischWEsserDWangYLangYet alEarly mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitisGastroenterology2011141119420110.1053/j.gastro.2011.06.05421723220Open DOISearch in Google Scholar

Baert F, Moortgat L, Van Assche G, Caenepeel P, Vergauwe P, De Vos M, et al. Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn’s disease. Gastroenterology 2010; 138: 463-8. doi: 10.1053/j. gastro.2009.09.056BaertFMoortgatLVanAssche GCaenepeelPVergauwePDe VosMet alMucosal healing predicts sustained clinical remission in patients with early-stage Crohn’s diseaseGastroenterology2010138463810.1053/j.gastro.2009.09.05619818785Open DOISearch in Google Scholar

Magnusson MK, Brynjólfsson SF, Dige A, Uronen-Hansson H, Börjesson LG, Bengtsson JL, et al. Macrophage and dendritic cell subsets in IBD: ALDH(+) cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation. Mucosal Immunol 2016; 9: 171-82. doi: 10.1038/mi.2015.48MagnussonMKBrynjólfssonSFDigeAUronen-HanssonHBörjessonLGBengtssonJLet alMacrophage and dendritic cell subsets in IBD: ALDH(+) cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammationMucosal Immunol201691718210.1038/mi.2015.48468312426080709Open DOISearch in Google Scholar

Annacker O, Coombes JL, Malmstrom V, Uhlig HH, Bourne T, Johansson-Lindbom B, et al. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med 2005; 202: 1051-61. doi: 10.1084/jem.20040662AnnackerOCoombesJLMalmstromVUhligHHBourneTJohansson-LindbomBet alEssential role for CD103 in the T cell-mediated regulation of experimental colitisJ Exp Med200520210516110.1084/jem.20040662221320616216886Open DOISearch in Google Scholar

Scott CL, Aumeunier AM, Mowat AM. Intestinal CD103+ dendritic cells: master regulators of tolerance? Trends Immunol 2011; 32: 412-9. doi: 10.1016/j.it.2011.06.003ScottCLAumeunierAMMowatAMIntestinal CD103+ dendritic cells: master regulators of tolerance?Trends Immunol201132412910.1016/j.it.2011.06.00321816673Open DOISearch in Google Scholar

del Rio ML, Bernhardt G, Rodriguez-Barbosa JI, Forster R. Development and functional specialization of CD103+ dendritic cells. Immunol Rev 2010; 234: 268-81. doi: 10.1111/j.0105-2896.2009.00874.xdel RioMLBernhardtGRodriguez-BarbosaJIForsterRDevelopment and functional specialization of CD103+ dendritic cellsImmunol Rev20102342688110.1111/j.0105-2896.2009.00874.x20193025Open DOISearch in Google Scholar

Cerovic V, Houston SA, Scott CL, Aumeunier A, Yrlid U, Mowat AM, et al. Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells. Mucosal Immunol 2013; 6: 104-13. doi: 10.1038/mi.2012.53CerovicVHoustonSAScottCLAumeunierAYrlidUMowatAMet alIntestinal CD103(-) dendritic cells migrate in lymph and prime effector T cellsMucosal Immunol201361041310.1038/mi.2012.5322718260Open DOISearch in Google Scholar

Ruane DT, Lavelle EC. The role of CD103(+) dendritic cells in the intestinal mucosal immune system. Front Immunol 2011; 2: 25. doi: 10.3389/fimmu.2011.00025RuaneDTLavelleECThe role of CD103(+) dendritic cells in the intestinal mucosal immune systemFront Immunol201122510.3389/fimmu.2011.00025334235622566815Open DOISearch in Google Scholar

Iliev ID, Spadoni I, Mileti E, Matteoli G, Sonzogni A, Sampietro GM, et al. Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 2009; 58: 1481-9. doi: 10.1136/gut.2008.175166IlievIDSpadoniIMiletiEMatteoliGSonzogniASampietroGMet alHuman intestinal epithelial cells promote the differentiation of tolerogenic dendritic cellsGut2009581481910.1136/gut.2008.17516619570762Open DOISearch in Google Scholar

Annaházi A, Molnár T. Pathogenesis of ulcerative colitis and Crohn’s disease: similarities, differences and a lot of things we do not know yet. J Clin Cell Immunol 2014; 5: 253. doi: 10.4172/2155-9899.1000253AnnaháziAMolnárT.Pathogenesis of ulcerative colitis and Crohn’s disease: similarities, differences and a lot of things we do not know yetJ Clin Cell Immunol2014525310.4172/2155-9899.1000253Open DOISearch in Google Scholar

Yarur AJ, Jain A, Sussman DA, Barkin JS, Quintero MA, Princen F, et al. The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study. Gut 2016; 65: 249-55. doi: 10.1136/gutjnl-2014-308099YarurAJJainASussmanDABarkinJSQuinteroMAPrincenFet alThe association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS studyGut2016652495510.1136/gutjnl-2014-30809925670812Open DOISearch in Google Scholar

Abraham C, Dulai PS, Vermeire S, Sandborn WJ. Lessons learned from trials targeting cytokine pathways in patients with inflammatory bowel diseases. Gastroenterology 2017; 152: 374-88. doi: 10.1053/j.gastro.2016.10.018AbrahamCDulaiPSVermeireSSandbornWJLessons learned from trials targeting cytokine pathways in patients with inflammatory bowel diseasesGastroenterology20171523748810.1053/j.gastro.2016.10.018528792227780712Open DOISearch in Google Scholar

Prieto-Perez R, Almoguera B, Cabaleiro T, Hakonarson H, Abad-Santos F. Association between genetic polymorphisms and response to anti-TNFs in patients with inflammatory bowel disease. Int J Mol Sci 2016; 17: 225. doi: 10.3390/ijms17020225Prieto-PerezRAlmogueraBCabaleiroTHakonarsonHAbad-SantosF.Association between genetic polymorphisms and response to anti-TNFs in patients with inflammatory bowel diseaseInt J Mol Sci20161722510.3390/ijms17020225478395726861312Open DOISearch in Google Scholar

Radwan P, Radwan-Kwiatek K, Tabarkiewicz J, Radej S, Rolinski J. Enhanced phenotypic and functional maturation of monocyte-derived dendritic cells from patients with active Crohn’s disease and ulcerative colitis. J Physiol Pharmacol 2010; 61: 695-703. PMID: 21224500RadwanPRadwan-KwiatekKTabarkiewiczJRadejSRolinskiJEnhanced phenotypic and functional maturation of monocyte-derived dendritic cells from patients with active Crohn’s disease and ulcerative colitisJ Physiol Pharmacol201061695703PMID: 21224500Search in Google Scholar

Vuckovic S, Florin TH, Khalil D, Zhang MF, Patel K, Hamilton I, et al. CD40 and CD86 upregulation with divergent CMRF44 expression on blood dendritic cells in inflammatory bowel diseases. Am J Gastroenterol 2001; 96: 2946-56. doi: 10.1111/j.1572-0241.2001.04686.xVuckovicSFlorinTHKhalilDZhangMFPatelKHamiltonIet alCD40 and CD86 upregulation with divergent CMRF44 expression on blood dendritic cells in inflammatory bowel diseasesAm J Gastroenterol20019629465610.1111/j.1572-0241.2001.04686.x11693331Open DOISearch in Google Scholar

Hart AL, Al-Hassi HO, Rigby RJ, Bell SJ, Emmanuel AV, Knight SC, et al. Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 2005; 129: 50-65. doi: 10.1053/j.gastro.2005.05.013HartALAl-HassiHORigbyRJBellSJEmmanuelAVKnightSCet alCharacteristics of intestinal dendritic cells in inflammatory bowel diseasesGastroenterology2005129506510.1053/j.gastro.2005.05.01316012934Open DOISearch in Google Scholar

Lombardi VC, Khaiboullina SF. Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology. Clin Immunol 2014; 153: 165-77. doi: 10.1016/j.clim.2014.04.007LombardiVCKhaiboullinaSFPlasmacytoid dendritic cells of the gut: relevance to immunity and pathologyClin Immunol20141531657710.1016/j.clim.2014.04.007406355924769378Open DOISearch in Google Scholar

Hostmann A, Kapp K, Beutner M, Ritz JP, Loddenkemper C, Ignatius R, et al. Dendritic cells from human mesenteric lymph nodes in inflammatory and non-inflammatory bowel diseases: subsets and function of plasmacytoid dendritic cells. Immunology 2013; 139: 100-8. doi: 10.1111/imm.12060HostmannAKappKBeutnerMRitzJPLoddenkemperCIgnatiusRet alDendritic cells from human mesenteric lymph nodes in inflammatory and non-inflammatory bowel diseases: subsets and function of plasmacytoid dendritic cellsImmunology2013139100810.1111/imm.12060363454223278129Open DOISearch in Google Scholar

Knight SC. Dendritic cell-T-cell circuitry in health and changes in inflammatory bowel disease and its treatment. Dig Dis 2016; 34: 51-7. doi: 10.1159/000442926KnightSCDendritic cell-T-cell circuitry in health and changes in inflammatory bowel disease and its treatmentDig Dis20163451710.1159/000442926502265926982806Open DOISearch in Google Scholar

Lagaraine C, Lebranchu Y. Effects of immunosuppressive drugs on dendritic cells and tolerance induction. Transplantation 2003; 75: 37s-42s. doi: 10.1097/01.tp.0000067950.90241.1dLagaraineCLebranchuYEffects of immunosuppressive drugs on dendritic cells and tolerance inductionTransplantation20037537s4210.1097/01.tp.0000067950.90241.1d12819489Open DOISearch in Google Scholar

Teig N, Moses D, Gieseler S, Schauer U. Age-related changes in human blood dendritic cell subpopulations. Scand J Immunol 2002; 55: 453-7. doi: 10.1046/j.1365-3083.2002.01068.xTeigNMosesDGieselerSSchauerUAge-related changes in human blood dendritic cell subpopulationsScand J Immunol200255453710.1046/j.1365-3083.2002.01068.x11975756Open DOISearch in Google Scholar

Bella SD, Bierti L, Presicce P, Arienti R, Valenti M, Saresella M, et al. Peripheral blood dendritic cells and monocytes are differently regulated in the elderly. Clin Immunol 2007; 122: 220-8. doi: 10.1016/j.clim.2006.09.012BellaSDBiertiLPresiccePArientiRValentiMSaresellaMet alPeripheral blood dendritic cells and monocytes are differently regulated in the elderlyClin Immunol2007122220810.1016/j.clim.2006.09.012Open DOISearch in Google Scholar

Dzutsev A, Hogg A, Sui Y, Solaymani-Mohammadi S, Yu H, Frey B, et al. Differential T cell homing to colon vs. small intestine is imprinted by local CD11c(+) APCs that determine homing receptors. J Leukoc Biol 2017; 102: 1381-8. doi: 10.1189/jlb.1A1116-463RRDzutsevAHoggASuiYSolaymani-MohammadiSYuHFreyBet alDifferential T cell homing to colon vs. small intestine is imprinted by local CD11c(+) APCs that determine homing receptorsJ Leukoc Biol20171021381810.1189/jlb.1A1116-463RROpen DOISearch in Google Scholar

Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, et al. Inherited determinants of Crohn’s disease and ulcerative colitis phenotypes: a genetic association study. Lancet 2016; 387: 156-67. doi: 10.1016/s0140-6736(15)00465-1CleynenIBoucherGJostinsLSchummLPZeissigSAhmadTet alInherited determinants of Crohn’s disease and ulcerative colitis phenotypes: a genetic association studyLancet20163871566710.1016/s0140-6736(15)00465-1Open DOISearch in Google Scholar

eISSN:
1581-3207
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology