<abstract xmlns="http://www.w3.org/1999/xhtml">Background. Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are insufficient. The aim of this study was to identify potential relationship between the hypodontia and epithelial ovarian cancer (EOC). Patients and methods. A retrospective study was conducted on 120 patients with EOC treated at the Department of Gynaecologic and Breast Oncology at the University Clinical Centre and 120 gynaecological healthy women (control group) of the same mean age. Women in both groups were reviewed for the presence of hypodontia and the patients with EOC also for clinicopathological characteristics of EOC according to hypodontia phenotype. Results. Hypodontia was diagnosed in 23 (19.2%) of patients with EOC and 8 (6.7%) controls (p = 0.004; odds ratio [OR] = 3.32; confidence interval [CI], 1.42-7.76). There was no statistically significant difference in patients with EOC with or without hypodontia regarding histological subtype (p = 0.220); they differed in regard to FIGO stage (p = 0.014; OR =3.26; CI, 1.23-8.64) and tumour differentiation grade (p = 0.042; OR = 3.1; CI, 1.01-9.53). Also, bilateral occurrence of EOC was more common than unilateral occurrence in women with hypodontia (p = 0.021; OR = 2.9; CI, 1.15-7.36). We also found statistically significant difference between the ovarian cancer group and control group in presence of other malignant tumours in subjects (p &lt; 0.001). Conclusions. The results of the study suggest a statistical association between EOC and hypodontia phenotype. Hypodontia might serve as a risk factor for EOC detection.</abstract>

Background. Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are insufficient. The aim of this study was to identify potential relationship between the hypodontia and epithelial ovarian cancer (EOC). Patients and methods. A retrospective study was conducted on 120 patients with EOC treated at the Department of Gynaecologic and Breast Oncology at the University Clinical Centre and 120 gynaecological healthy women (control group) of the same mean age. Women in both groups were reviewed for the presence of hypodontia and the patients with EOC also for clinicopathological characteristics of EOC according to hypodontia phenotype. Results. Hypodontia was diagnosed in 23 (19.2%) of patients with EOC and 8 (6.7%) controls (p = 0.004; odds ratio [OR] = 3.32; confidence interval [CI], 1.42-7.76). There was no statistically significant difference in patients with EOC with or without hypodontia regarding histological subtype (p = 0.220); they differed in regard to FIGO stage (p = 0.014; OR =3.26; CI, 1.23-8.64) and tumour differentiation grade (p = 0.042; OR = 3.1; CI, 1.01-9.53). Also, bilateral occurrence of EOC was more common than unilateral occurrence in women with hypodontia (p = 0.021; OR = 2.9; CI, 1.15-7.36). We also found statistically significant difference between the ovarian cancer group and control group in presence of other malignant tumours in subjects (p < 0.001). Conclusions. The results of the study suggest a statistical association between EOC and hypodontia phenotype. Hypodontia might serve as a risk factor for EOC detection.

Hypodontia phenotype in patients with epithelial ovarian cancer

Department of Orthodontics, Health Centre Maribor, Maribor, Slovenia

Medical Faculty, University of Maribor, Maribor, Slovenia

Department of Maxillofacial and Oral Surgery, Teaching Hospital Celje, Celje, Slovenia

Department of Gynaecologic and Breast Oncology, Clinical Department of Gynaecology and Perinatology, University Clinical Centre Maribor, Maribor, Slovenia

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Hypodontia phenotype in patients with epithelial ovarian cancer"}

Background. Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are...

Hypodontia phenotype in patients with epithelial ovarian cancer

Published Online: Mar 03, 2015

Page range: 65 - 70

Received: Dec 31, 2013

Accepted: Apr 27, 2014

DOI: https://doi.org/10.2478/raon-2014-0034

Keywords
hypodontia, epithelial ovarian cancer, risk factor, early stage diagnosis

© by Anita Fekonja

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Hypodontia phenotype in patients with epithelial ovarian cancer

Published Online: Mar 03, 2015

Page range: 65 - 70

Received: Dec 31, 2013

Accepted: Apr 27, 2014

DOI: https://doi.org/10.2478/raon-2014-0034

Keywordshypodontia, epithelial ovarian cancer, risk factor, early stage diagnosis

© by Anita Fekonja

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
hypodontia, epithelial ovarian cancer, risk factor, early stage diagnosis