Post-mastectomy radiotherapy benefits subgroups of breast cancer patients with T1-2 tumor and 1–3 axillary lymph node(s) metastasis

1. Ragaz J, Olivotto IA, Spinelli JJ, Phillips N, Jackson SM, Wilson KS, et al. Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst 2005; 97: 116-26.10.1093/jnci/djh297Search in Google Scholar

2. Overgaard M, Jensen MB, Overgaard J, Hansen PS, Rose C, Andersson M, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 1999; 353: 1641-8.10.1016/S0140-6736(98)09201-0Search in Google Scholar

3. Ragaz J, Jackson SM, Le N, Plenderleith IH, Spinelli JJ, Basco VE, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 1997; 337: 956-62.10.1056/NEJM199710023371402Search in Google Scholar

4. Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med 1997; 337: 949-55.10.1056/NEJM199710023371401Search in Google Scholar

5. Gebski V, Lagleva M, Keech A, Simes J, Langlands AO. Survival effects of postmastectomy adjuvant radiation therapy using biologically equivalent doses: a clinical perspective. J Natl Cancer Inst 2006; 98: 26-38.10.1093/jnci/djj002Search in Google Scholar

6. Van de Steene J, Vinh-Hung V, Cutuli B, Storme G. Adjuvant radiotherapy for breast cancer: effects of longer follow-up. Radiother Oncol 2004; 72: 35-43.10.1016/j.radonc.2004.04.004Search in Google Scholar

7. Whelan TJ, Julian J, Wright J, Jadad AR, Levine ML. Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol 2000; 18: 1220-9.10.1200/JCO.2000.18.6.1220Search in Google Scholar

8. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 366: 2087-106.10.1016/S0140-6736(05)67887-7Search in Google Scholar

9. Recht A, Edge SB, Solin LJ, Robinson DS, Estabrook A, Fine RE, et al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 2001; 19: 1539-69.10.1200/JCO.2001.19.5.153911230499Search in Google Scholar

10. Gnant M, Harbeck N, Thomssen C. St. Gallen 2011: Summary of the consensus discussion. Breast Care 2011; 6: 136-41.10.1159/000328054310037621633630Search in Google Scholar

11. Vélez-García E, Carpenter JT, Moore M, Vogel CL, Marcial V, Ketcham A, et al. Postsurgical adjuvant chemotherapy with or without radiotherapy in women with breast cancer and positive axillary nodes: a South-Eastern Cancer Study Group (SEG) Trial. Eur J Cancer 1992; 28: 1833-7. 10.1016/0959-8049(92)90015-TSearch in Google Scholar

12 . McArdle CS, Crawford D, Dykes EH, Calman KC, Hole D, Russell AR, et al. Adjuvant radiotherapy and chemotherapy in breast cancer. Br J Surg 1986; 73: 264-6. 10.1002/bjs.1800730407Search in Google Scholar

13 . Taghian A, Jeong J-H, Mamounas E, Anderson S, Bryant J, Deutsch M, et al. Patterns of locoregional failure in patients with operable breast cancer treated by mastectomy and adjuvant chemotherapy with or without tamoxifen and without radiotherapy: results from five National surgical adjuvant breast and bowel project randomized clinical trials. J Clin Oncol 2004; 22: 4247-54. 10.1200/JCO.2004.01.042Search in Google Scholar

14 . Wallgren A, Bonetti M, Gelber RD, Goldhirsch A, Castiglione-Gertsch M, Holmberg SB, et al. Risk factors for locoregional recurrence among breast cancer patients: results from International Breast Cancer Study Group Trials I through VII. J Clin Oncol 2003; 21: 1205-13. 10.1200/JCO.2003.03.130Search in Google Scholar

15 . Katz A, Strom EA, Buchholz TA, Thames HD, Smith CD, Jhingran A, et al. Locoregional recurrence patterns after mastectomy and doxorubicin-based chemotherapy: implications for postoperative irradiation. J Clin Oncol 2000; 18: 2817-27. 10.1200/JCO.2000.18.15.2817Search in Google Scholar

16 . Recht A, Gray R, Davidson NE, Fowble BL, Solin LJ, Cummings FJ, et al. Locoregional failure 10 years after mastectomy and adjuvant chemotherapy with or without tamoxifen without irradiation: experience of the Eastern Cooperative Oncology Group. J Clin Oncol 1999; 17: 1689-700. 10.1200/JCO.1999.17.6.1689Search in Google Scholar

17 . Overgaard M, Nielsen HM, Overgaard J. Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials. Radiother Oncol 2007; 82: 247-53. 10.1016/j.radonc.2007.02.001Search in Google Scholar

18 . Truong PT, Lesperance M, Culhaci A, Kader HA, Speers CH, Olivotto IA. Patient subsets with T1-T2, node-negative breast cancer at high locoregional recurrence risk after mastectomy. Int J Radiat Oncol Biol Phys 2005; 62: 175-82. 10.1016/j.ijrobp.2004.09.013Search in Google Scholar

19 . Truong PT, Berthelet E, Lee J, Kader HA, Olivotto IA. The prognostic significance of the percentage of positive/dissected axillary lymph nodes in breast cancer recurrence and survival in patients with one to three positive axillary lymph nodes. Cancer 2005; 103: 2006-14. 10.1002/cncr.20969Search in Google Scholar

20 . Lauria R, Perrone F, Carlomagno C, De Laurentiis M, Morabito A, Gallo C, et al. The prognostic value of lymphatic and blood vessel invasion in operable breast cancer. Cancer 1995; 76: 1772-8. 10.1002/1097-0142(19951115)76:10<1772::AID-CNCR2820761014>3.0.CO;2-OSearch in Google Scholar

21 . Yildirim E, Berberoglu U. Local recurrence in breast carcinoma patients with T(1-2) and 1-3 positive nodes: indications for radiotherapy. Eur J Surg Oncol 2007; 33: 28-32. 10.1016/j.ejso.2006.10.022Search in Google Scholar

22 . Cheng JC-H, Chen CM, Liu MC, Tsou MH, Yang PS, Jian JJ-M, et al. Locoregional failure of postmastectomy patients with 1-3 positive axillary lymph nodes without adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 2002; 52: 980-8.10.1016/S0360-3016(01)02724-9Search in Google Scholar

23. Katz A, Strom EA, Buchholz TA, Theriault R, Singletary SE, McNeese MD. The influence of pathologic tumor characteristics on locoregional recurrence rates following mastectomy. Int J Radiat Oncol Biol Phys 2001; 50: 735-42.10.1016/S0360-3016(01)01500-0Search in Google Scholar

24. Jager JJ, Volovics L, Schouten LJ, de Jong JM, Hupperets PS, von Meyenfeldt MF, et al. Loco-regional recurrences after mastectomy in breast cancer: prognostic factors and implications for postoperative irradiation. Radiother Oncol 1999; 50: 267-75.10.1016/S0167-8140(98)00118-2Search in Google Scholar

25. Karlsson P, Cole BF, Chua BH, Price KN, Lindtner J, Collins JP, et al. Patterns and risk factors for locoregional failures after mastectomy for breast cancer: an International Breast Cancer Study Group report. Ann Oncol 2012; 23: 2852-8.10.1093/annonc/mds118347788022776708Search in Google Scholar

26. Hunt KK, Ballman KV, McCall LM, Boughey JC, Mittendorf EA, Cox CE, et al. Factors associated with local-regional recurrence after a negative sentinel node dissection. Ann Surg 2012; 256: 428-36.10.1097/SLA.0b013e3182654494534574622868365Search in Google Scholar

27. Albert JM, Gonzalez-Angulo AM, Guray M, Sahin A, Strom EA, Tereffe W, et al. Estrogen/progesterone receptor negativity and HER2 positivity predict locoregional recurrence in patients with T1a,bN0 breast cancer. Int J Radiat Oncol Biol Phys 2010; 77: 1296-302.10.1016/j.ijrobp.2009.12.01120472353Search in Google Scholar

28. Pietras RJ, Poen JC, Gallardo D, Wongvipat PN, Lee HJ, Slamon DJ. Monoclonal antibody to HER-2/neureceptor modulates repair of radiationinduced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res 1999; 59: 1347-55.Search in Google Scholar

29. Pirollo KF, Tong YA, Villegas Z, Chen Y, Chang EH. Oncogene- transformed NIH 3T3 cells display radiation resistance levels indicative of a signal transduction pathway leading to the radiation-resistant phenotype. Radiat Res 1993; 135: 234-43.10.2307/3578300Search in Google Scholar

30. Duraker N, Demir D, Bati B, Yilmaz BD, Bati Y, Caynak ZC, et al. Survival benefit of post-mastectomy radiotherapy in breast carcinoma patients with T1-2 tumor and 1-3 axillary lymph node(s) metastasis. Jpn J Clin Oncol 2012; 42: 601-8.10.1093/jjco/hys05222511807Search in Google Scholar

31. Song YJ, Shin SH, Cho JS, Park MH, Yoon JH, Jegal YJ. The Role of Lymphovascular invasion as a prognostic factor in patients with lymph nodepositive operable invasive breast cancer. J Breast Cancer 2011; 14: 198-203.10.4048/jbc.2011.14.3.198320051522031801Search in Google Scholar

32. Duraker N, Batı B, Demir D, Çaynak ZC. Prognostic significance of the number of removed and metastatic lymph nodes and lymph node ratio in breast carcinoma patients with 1-3 axillary lymph node(s) metastasis. Oncology 2011; 2011: 1-10.Search in Google Scholar

33. Truong PT, Olivotto IA, Kader HA, Panades M, Speers CH, Berthelet E. Selecting breast cancer patients with T1-T2 tumors and one to three positive axillary nodes at high postmastectomy locoregional recurrence risk for adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 2005; 61: 1337-47.10.1016/j.ijrobp.2004.08.009Search in Google Scholar

34. Nitsche M, Hermann R. Axillary irradiation as an imperative alternative to axillary dissection in clinically lymph node-negative but sentinel node-positive breast cancer patients? Breast Care 2011; 6: 353-8.Search in Google Scholar

35. Woo CS, Silberman H, Nakamura SK, Ye W, Sposto R, Colburn W, et al. Lymph node status combined with lymphovascular invasion creates a more powerful tool for predicting outcome in patients with invasive breast cancer. Am J Surg 2002; 184: 337-40.10.1016/S0002-9610(02)00950-9Search in Google Scholar

36. McCready DR, Chapman JA, Hanna WM, Kahn HJ, Murray D, Fish EB, et al. Factors affecting distant disease-free survival for primary invasive breast cancer: use of a log-normal survival model. Ann Surg Oncol 2000; 7: 416-26.10.1007/s10434-000-0416-z10894137Search in Google Scholar

37. Trovo M, Durofil E, Polesel J, Roncadin M, Perin T, Mileto M, et al. Locoregional failure in early-stage breast cancer patients treated with radical mastectomy and adjuvant systemic therapy: Which patients benefit from postmastectomy irradiation? Int J Radiat Oncol Biol Phys 2012; 83: e153-e157.10.1016/j.ijrobp.2011.12.05022386375Search in Google Scholar

38. Nagao T, Kinoshita T, Tamura N, Hojo T, Morota M, Kagami Y. Locoregional recurrence risk factors in breast cancer patients with positive axillary lymph nodes and the impact of postmastectomy radiotherapy. Int J Clin Oncol 2013; 18: 54-6110.1007/s10147-011-0343-y22068463Search in Google Scholar

39. Yang PS, Chen CM, Liu MC, Jian JM, Horng CF, Liu MJ, et al. Radiotherapy can decrease locoregional recurrence and increase survival in mastectomy patients with T1 to T2 breast cancer and one to three positive nodes with negative estrogen receptor and positive lymphovascular invasion status. Int J Radiat Oncol Biol Phys 2010; 77: 516-22.10.1016/j.ijrobp.2009.05.01619577858Search in Google Scholar

40. Kyndi M, Sørensen FB, Knudsen H, Overgaard M, Nielsen HM, Overgaard J, et al. Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the Danish Breast Cancer Cooperative Group. J Clin Oncol 2008; 26: 1419-26.10.1200/JCO.2007.14.556518285604Search in Google Scholar

41. Rucigaj TP, Leskovec NK, Zunter VT. Lymphedema following cancer therapy in Slovenia: a frequently overlooked condition? Radiol Oncol 2010; 44: 244-8. Search in Google Scholar