Association Between 4q25 Variants, Risk of Atrial Fibrillation and Echocardiographic Parameters

Aguirre, L. A., Alonso, M. E., Badía-Careaga, C., Rollán, I., Arias, C., Fernández-Miñán, A., López-Jiménez, E., Aránega, A., Gómez-Skarmeta, J. L., Franco, D., Manzanares, M. (2015). Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP. BMC Biol., 13, 26.10.1186/s12915-015-0138-0441633925888893Search in Google Scholar

Benjamin Shoemaker, M., Muhammad, R., Parvez, B., White, B.W., Streur, M., Song, Y., Stubblefield, T., Kucera, G., Blair, M., Rytlewski, J., et al. (2013). Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation. Heart Rhythm,10, 394–400.10.1016/j.hrthm.2012.11.012358735723178686Search in Google Scholar

Bodineau, L., Frugičre, A., Marc, Y., Claperon, C., Llorens-Cortes, C. (2008). Aminopeptidase A inhibitors as centrally acting antihypertensive agents. Heart Failure Rev., 13, 311–319.10.1007/s10741-007-9077-318175217Search in Google Scholar

Campione, M., Steinbeisser, H., Schweickert, A., Deissler, K., van Bebber, F., Lowe, L. A., Nowotschin, S., Viebahn, C., Haffter, P., Kuehn, M. R., Blum, M. (1999). The homeobox gene Pitx2: Mediator of asymmetric left-right signaling in vertebrate heart and gut looping. Development,126, 1225–1234.10.1242/dev.126.6.122510021341Search in Google Scholar

Chen, F., Yang, Y., Zhang, R., Zhang, S., Dong, Y., Yin, X., Chang, D., Yang, Z., Wang, K., Gao, L., Xia, Y. (2016). Polymorphism rs2200733 at chromosome 4q25 is associated with atrial fibrillation recurrence after radiofrequency catheter ablation in the Chinese Han population. Amer. J. Transl. Res.,8, 688–697.Search in Google Scholar

Chugh, S. S., Havmoeller, R., Narayanan, K., Singh, D., Rienstr, M, Benjamin, E. J., Gillum, R. F., Kim, Y. H., McAnulty, J. H., Zheng, Z. J., Forouzanfar, M. H., Naghavi, M., Mensah, G. A., Ezzati, M., Murray, C. J. (2014). Worldwide epidemiology of atrial fibrillation. Circulation, 129, 837–847.10.1161/CIRCULATIONAHA.113.005119415130224345399Search in Google Scholar

Cochet, H., Dubois, R., Yamashita, S., Al Jefairi, N., Berte, B., Sellal, J.-M., Hooks, D., Frontera, A., Amraoui, S., Zemoura, A., et al. (2018). Relationship between fibrosis detected on late gadolinium-enhanced cardiac magnetic resonance and re-entrant activity assessed with electrocardiographici in human persistent atrial fibrillation. JACC Clin. Electrophysiol.,4, 17–29.10.1016/j.jacep.2017.07.019582473129479568Search in Google Scholar

Ellinor, P. T., Lunetta, K. L., Albert, C. M., Glazer, N. L., Ritchie, M. D., Smith, A. V., Arking, D. E., Müller-Nurasyid, M., Krijthe, B. P., Lubitz, S. A., et al. (2012). Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat. Genet., 44, 670–675.10.1038/ng.2261336603822544366Search in Google Scholar

Feghal, J., Zakka, P., London, B., MacRae, C. A., Refaat, M. M. (2018). Genetics of atrial fibrillation. J. Amer. Heart Assoc., 7, e009884.10.1161/JAHA.118.009884647496030371258Search in Google Scholar

Ferrán, A., Alegret, J. M., Subirana, I., Aragončs, G., Lluis-Ganella, C., Romero-Menor, C., Planas, F., Joven, J., Elosua, R. (2014). Association between rs2200733 and rs7193343 genetic variants and atrial fibrillation in a Spanish population, and meta-analysis of previous studies. Rev. Esp. Cardiol. (Engl Ed)67, 822–829.10.1016/j.recesp.2013.12.021Search in Google Scholar

Gore-Panter, S. R., Hsu, J., Hanna, P., Gillinov, A. M., Pettersson, G., Newton, D. W., Moravec, C. S., Van Wagoner, D. R., Chung, M. K., Barnard, J., Smith, J. D. (2014). Atrial Fibrillation associated chromosome 4q25 variants are not associated with PITX2c expression in human adult left atrial appendages. PLoS ONE, 9, e86245.10.1371/journal.pone.0086245389922524465984Search in Google Scholar

Gudbjartsson, D. F., Arnar, D. O., Helgadottir, A., Gretarsdottir, S., Holm, H., Sigurdsson, A., Jonasdottir, A., Baker, A., Thorleifsson, G., Kristjansson, K., et al. (2007). Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature,448, 353–357.10.1038/nature06007Search in Google Scholar

Husser, D., Adams, V., Piorkowski, C., Hindricks, G., Bollmann, A. (2010). Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation. J. Amer. Coll. Cardiol.,55, 747–753.10.1016/j.jacc.2009.11.041Search in Google Scholar

Iwasaki, Y., Nishida, K., Kato, T., Nattel, S. (2011). Atrial fibrillation pathophysiology: Implications for management. Circulation,124, 2264–2274.10.1161/CIRCULATIONAHA.111.019893Search in Google Scholar

Kahr, P. C., Piccini, I., Fabritz, L., Greber, B., Schöler, H., Scheld, H. H., Hoffmeier, A., Brown, N. A., Kirchhof, P. (2011). Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue. PLoS ONE, 6, e26389.10.1371/journal.pone.0026389Search in Google Scholar

Kathiriya, I. S., Srivastava, D. (2000). Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease. Amer. J. Med. Genet.,97, 271–279.10.1002/1096-8628(200024)97:4<271::AID-AJMG1277>3.0.CO;2-OSearch in Google Scholar

Kiliszek, M., Franaszczyk, M., Kozluk, E., Lodzinski, P., Piatkowska, A., Broda, G., Ploski, R., Opolski, G. (2011). Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population. PLoS ONE, 6, e21790.10.1371/journal.pone.0021790Search in Google Scholar

Kirchhof, P., Kahr, P. C., Kaese, S., Piccini, I., Vokshi, I., Scheld, H.-H., Rotering, H., Fortmueller, L., Laakmann, S., Verheule, S., Schotten, U., Fabritz, L., Brown, N. A. (2011). PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Circ. Cardiovasc. Genet.,4, 123–133.10.1161/CIRCGENETICS.110.958058Search in Google Scholar

Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur. J. Cardiothorac. Surg.,50, e1–e88.10.1016/j.rec.2016.11.033Search in Google Scholar

Knackstedt, C., Gramley, F., Schimpf, T., Mischke, K., Zarse, M., Plisiene, J., Schmid, M., Lorenzen, J., Frechen, D., Neef, P., Hanrath, P., Kelm, M., Schauerte, P. (2008). Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial fibrillation. Cardiovascu. Pathol.,17, 318–324.10.1016/j.carpath.2007.12.003Search in Google Scholar

Lee, J., Jang, I. (2018). Predictors affecting postoperative atrial fibrillation in patients after coronary artery bypass graft. Clin. Nurs. Res., doi: 10.1177/1054773818809285.10.1177/1054773818809285Search in Google Scholar

Lee, K.-T., Yeh, H.-Y., Tung, C.-P., Chu, C.-S., Cheng, K.-H., Tsai, W.-C., Lu, Y.-H., Chang, J.-G., Sheu, S.-H., Lai, W.-T. (2010a). Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. Cardiology, 116, 151–156.10.1159/000318172Search in Google Scholar

Lee, Y.-S., Hyun, D. W., Jung, B. C., Cho, Y. K., Lee, S. H., Shin, D. G., Park, H. S., Han, S. W., Kim, Y. N. (2010b). Left atrial volume index as a predictor for occurrence of atrial fibrillation after ablation of typical atrial flutter. J. Cardiol.,56, 348–353.10.1016/j.jjcc.2010.07.00620889311Search in Google Scholar

Lijnen, P. J., Petrov, V. V., Fagard, R. H. (2000). Induction of cardiac fibrosis by angiotensin II. Methods Find Exp. Clin. Pharmacol., 22, 709–723.10.1358/mf.2000.22.10.80228711346891Search in Google Scholar

Liu, L., Ebana, Y., Nitta, J.-I., Takahashi, Y., Miyazaki, S., Tanaka, T., Komura, M., Isobe, M., Furukawa, T. (2017). Genetic variants associated with susceptibility to atrial fibrillation in a Japanese population. Can. J. Cardiol.,33, 443–449.10.1016/j.cjca.2016.10.02928129963Search in Google Scholar

Lubitz, S. A., Lunetta, K. L., Lin, H., Arking, D. E., Trompet, S., Li, G., Krijthe, B. P., Chasman, D. I., Barnard, J., Kleber, M. E., et al. (2014). Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. J. Amer. Coll. Cardiol., 63, 1200–1210.10.1016/j.jacc.2013.12.015400924024486271Search in Google Scholar

Mancio, J., Azevedo, D., Fragao-Marques, M., Falcao-Pires, I., Leite-Moreira, A., Lunet, N., Fontes-Carvalho, R., Bettencourt, N. (2018). Meta-analysis of relation of epicardial adipose tissue volume to left atrial dilation and to left ventricular hypertrophy and functions. Amer. J. Cardiol.,123, 523–531.10.1016/j.amjcard.2018.10.020Search in Google Scholar

Mints, Y., Yarmohammadi, H., Khurram, I. M., Hoyt, H., Hansford, R., Zimmerman, S. L., Steinberg, S. J., Judge, D. P., Tomaselli, G. F., Calkins, H., Zipunnikov, V., Nazarian, S. (2015). Association of common variations on chromosome 4q25 and left atrial volume in patients with atrial fibrillation. Clin. Med. Insights Cardiol.,9, 39–45.10.4137/CMC.S21712443147726005361Search in Google Scholar

Mizutani, S., Ishii, M., Hattori, A., Nomura, S., Numaguchi, Y., Tsujimoto, M., Kobayshi, H., Murohara, T., Wright, J. W. (2008). New insights into the importance of aminopeptidase A in hypertension. Heart Failure Rev.,13, 273–284.10.1007/s10741-007-9065-7710167417990103Search in Google Scholar

Mommersteeg, M. T. M., Brown, N. A., Prall, O. W. J., de Gier-de Vries, C., Harvey, R. P., Moorman, A. F. M., Christoffels, V. M. (2007). Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium. Circ. Res.101, 902–909.10.1161/CIRCRESAHA.107.16118217823370Search in Google Scholar

Morgan, R., Colman, M. A., Chubb, H., Seemann, G., Aslanidi, O. V. (2016). Slow conduction in the border zones of patchy fibrosis stabilizes the drivers for atrial fibrillation: Insights from multi-scale human atrial modeling. Front Physiol.,7, 474.10.3389/fphys.2016.00474507909727826248Search in Google Scholar

Morsy, M., Slomka, T., Shukla, A., Uppal, D., Bomb, R., Akinseye, O. A., Koshy, S. K. G., Garg, N. (2018). Clinical and echocardiographic predictors of new-onset atrial fibrillation in patients admitted with blunt trauma. Echocardiography, 35, 1519–1524.10.1111/echo.1409029981181Search in Google Scholar

Nielsen, J. B., Thorolfsdottir, R. B., Fritsche, L. G., Zhou, W., Skov, M. W., Graham, S. E., Herron, T. J., McCarthy, S., Schmidt, E. M., Sveinbjornsson, G., et al. (2018). Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. Nat. Genet., 50, 1234–1239.10.1038/s41588-018-0171-3653077530061737Search in Google Scholar

Nistri, S., Galderisi, M., Ballo, P., Olivotto, I., D’Andrea, A., Pagliani, L., Santoro, A., Papesso, B., Innelli, P., Cecchi, F., Mondillo, S. (2011). Determinants of echocardiographic left atrial volume: Implications for normalcy. Eur. J. Echocardiogr.,12, 826–833.10.1093/ejechocard/jer137Search in Google Scholar

Olsen, F. J., Møgelvang, R., Jensen, G. B., Jensen, J. S., Biering-Sørensen, T. (2018). Relationship between left atrial functional measures and incident atrial fibrillation in the general population. JACC: Cardiovasc. Imaging,18, 14–17.Search in Google Scholar

O’Neal, W. T., Sandesara, P., Patel, N., Venkatesh, S., Samman-Tahhan, A., Hammadah, M., Kelli, H. M., Soliman, E. Z. (2017). Echocardiographic predictors of atrial fibrillation in patients with heart failure with preserved ejection fraction. Eur. Heart J. Cardiovasc. Imaging,18, 725–729.10.1093/ehjci/jex038Search in Google Scholar

O’Neill, J., Swoboda, P. P., Plein, S., Tayebjee, M. H. (2018). Left atrial size and function in a South Asian population and their potential influence on the risk of atrial fibrillation. Clin. Cardiol.,41, 1379–1385.10.1002/clc.23064Search in Google Scholar

Plawecki, M., Morena, M., Kuster, N., Chenine, L., Leray-Moragues, H., Jover, B., Fesler, P., Lotierzo, M., Dupuy, A.-M., Klouche, K., Cristol, J. P. (2018). sST2 as a new biomarker of chronic kidney disease-induced cardiac remodeling: Impact on risk prediction. Mediators Inflamm.,2018, 3952526.10.1155/2018/3952526Search in Google Scholar

Roselli, C., Chaffin, M. D., Weng, L.-C., Aeschbacher, S., Ahlberg, G., Albert, C. M., Almgren, P., Alonso, A., Anderson, C. D., Aragam, K. G., et al. (2018). Multi-ethnic genome-wide association study for atrial fibrillation. Nat. Genet., 50, 1225–1233.10.1038/s41588-018-0133-9Search in Google Scholar

Saha, M., Roney, C. H., Bayer, J. D., Meo, M., Cochet, H., Dubois, R., Vigmond, E. J. (2018). Wavelength and fibrosis affect phase singularity locations during atrial fibrillation. Front Physiol, 9, 1207.10.3389/fphys.2018.01207Search in Google Scholar

Sanfilippo, A. J., Abascal, V. M., Sheehan, M., Oertel, L. B., Harrigan, P., Hughes, R. A., Weyman, A. E. (1990). Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study. Circulation, 82, 792–797.10.1161/01.CIR.82.3.792Search in Google Scholar

Schnabel, R. B., Yin, X., Gona, P., Larson, M. G., Beiser, A. S., McManus, D. D., Newton-Cheh, C., Lubitz, S. A., Magnani, J. W., Ellinor, P. T., Seshadri, S., Wolf, P. A., Vasan, R. S., Benjamin, E. J., Levy, D. (2015). 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: A cohort study. Lancet,386, 154–162.10.1016/S0140-6736(14)61774-8Search in Google Scholar

Shin, S.-H., Park, M.-Y., Oh, W.-J., Hong, S.-J., Pak, H.-N., Song, W.-H., Lim, D.-S., Kim, Y.-H., Shim, W.-J. (2008). Left atrial volume is a predictor of atrial fibrillation recurrence after catheter ablation. J. Amer. Soc. Echocardiogr.,21, 697–702.10.1016/j.echo.2007.10.02218187293Search in Google Scholar

Shoemaker, M. B., Bollmann, A., Lubitz, S. A., Ueberham, L., Saini, H., Montgomery, J., Edwards, T., Yoneda, Z., Sinner, M. F., Arya, A., et al. (2015). Common genetic variants and response to atrial fibrillation ablation. Circ. Arrhythm. Electrophysiol.,8, 296–302.10.1161/CIRCEP.114.001909473187125684755Search in Google Scholar

Tanabe, K., Yamaguchi, K., Tani, T., Yagi, T., Katayama, M., Tamita, K., Kinoshita, M., Kaji, S., Yamamuro, A., Morioka, Sokada, Y., Kihara, Y. (2007). Left atrial volume: Predictor of atrial fibrillation in patients with degenerative mitral regurgitation. J. Heart Valve Dis.,16, 8–12.Search in Google Scholar

Tao, Y., Zhang, M., Li, L., Bai, Y., Zhou, Y., Moon, A. M., Kaminski, H. J., Martin, J. F. (2014). Pitx2, an atrial fibrillation predisposition gene, directly regulates ion transport and intercalated disc genes. Circ. Cardiovasc. Genet.,7, 23–32.10.1161/CIRCGENETICS.113.000259401350024395921Search in Google Scholar

Voskoboinik, A., Costello, B. T., Kalman, E., Prabhu, S., Sugumar, H., Wong, G., Nalliah, C., Ling, L.-H., McLellan, A., Hettige, T., Springer, F., La Gerche, A., Kalman, J. M., Taylor, A. J., Kistler, P. M. (2018). Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population: A cross-sectional MRI-based study. JACC Clin. Electrophysiol.,4, 1451–1459.10.1016/j.jacep.2018.07.01030466852Search in Google Scholar

Wang, J., Klysik, E., Sood, S., Johnson, R. L., Wehrens, X. H. T., Martin, J. F. (2010). Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc. Natl. Acad. Sci. U.S.A., 107, 9753–9758.10.1073/pnas.0912585107290683820457925Search in Google Scholar

Ye, J., Tucker, N. R., Weng, L.-C., Clauss, S., Lubitz, S. A., Ellinor, P. T. (2016). A functional variant associated with atrial fibrillation regulates PITX2c expression through TFAP2a. Amer. J. Hum. Genet.,99, 1281–1291.10.1016/j.ajhg.2016.10.001514210627866707Search in Google Scholar

Zoni-Berisso, M., Lercari, F., Carazza, T., Domenicucci, S. (2014). Epidemiology of atrial fibrillation: European perspective. Clin. Epidemiol.,6, 213–220.10.2147/CLEP.S47385406495224966695Search in Google Scholar