<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Local antibiotic therapy has several advantages over systemic antibiotic treatment. Using antibiotics in local biomaterial systems can reduce the number of microorganisms that can adhere to implanted biomaterials. In this <italic>in vitro</italic> study, antibacterial properties of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers were examined. The antibacterial efficiency of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers against <italic>Staphylococcus epidermidis</italic> and <italic>Pseudomonas aeruginosa</italic> was studied by evaluating the expression of inflammatory cytokines (Interleukin-10 (IL-10), -defensin-2 and tumour necrosis factor alpha (TNF- )) in tissue surrounding implanted biomaterials <italic>in vivo</italic>. The results of this study demonstrated that hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers had a prolonged antibacterial effect in comparison to biomaterials without biodegradable polymers. Surrounding tissue displayed higher levels of inflammatory cytokines when implanted biomaterials had not been previously impregnated with antibiotics.</p></abstract>

Local antibiotic therapy has several advantages over systemic antibiotic treatment. Using antibiotics in local biomaterial systems can reduce the number of microorganisms that can adhere to implanted biomaterials. In this in vitro study, antibacterial properties of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers were examined. The antibacterial efficiency of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa was studied by evaluating the expression of inflammatory cytokines (Interleukin-10 (IL-10), -defensin-2 and tumour necrosis factor alpha (TNF- )) in tissue surrounding implanted biomaterials in vivo. The results of this study demonstrated that hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers had a prolonged antibacterial effect in comparison to biomaterials without biodegradable polymers. Surrounding tissue displayed higher levels of inflammatory cytokines when implanted biomaterials had not been previously impregnated with antibiotics.

Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines

Department of Oral and Maxillofacial Surgery

Faculty of Material Science and Applied Chemistry

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines"}

Local antibiotic therapy has several advantages over systemic antibiotic treatment. Using antibiotics in local biomaterial systems can reduce the number of...

Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines

Published Online: Apr 07, 2019

Page range: 177 - 184

Received: Nov 07, 2018

Accepted: Jan 03, 2019

DOI: https://doi.org/10.2478/prolas-2019-0028

Keywords
impregnated biomaterials, interleukin-10, -defensin-2, TNF-

© 2019 Ingus Skadiņš et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines

Published Online: Apr 07, 2019

Page range: 177 - 184

Received: Nov 07, 2018

Accepted: Jan 03, 2019

DOI: https://doi.org/10.2478/prolas-2019-0028

Keywordsimpregnated biomaterials, interleukin-10, -defensin-2, TNF-

© 2019 Ingus Skadiņš et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
impregnated biomaterials, interleukin-10, -defensin-2, TNF-