Evaluation of the Effects of Gastro Protect as an Alternative Medicine on Gastritis and Other Gastrointestinal Symptoms

1Marcial G, Rodriguez C, Medici M, de Valdez GF. New Approaches in Gastritis Treatment [Internet]. Gastritis and Gastric Cancer - New Insights in Gastroprotection, Diagnosis and Treatments. InTech; 2011. Available from: http://dx.doi.org/10.5772/23221Search in Google Scholar

2Feyisa ZT, Woldeamanuel BT. Prevalence and associated risk factors of gastritis among patients visiting Saint Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia. PLoS One. 2021 Feb 9;16(2):e0246619. doi: 10.1371/journal.pone.0246619. PMID: 33561152; PMCID: PMC7872234.Open DOISearch in Google Scholar

3Rugge, M., Sugano, K., Sacchi, D. et al. Gastritis: An Update in 2020. Curr Treat Options Gastro 18, 488–503 (2020). https://doi.org/10.1007/s11938-020-00298-8.Search in Google Scholar

4Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64(9):1353–67. https://doi.org/10.1136/gutjnl-2015-309252. The publication refers the results of a global consensus concerning the taxonomy of gastritis.Search in Google Scholar

5Fallone CA, Moss SF, Malfertheiner P. Reconciliation of recent Helicobacter pylori treatment guidelines in a time of increasing resistance to antibiotics. Gastroenterology. 2019;157(1):44–53. https://doi.org/10.1053/j.gastro.2019.04.011.Search in Google Scholar

6Welz, A.N., Emberger-Klein, A. &Menrad, K. Why people use herbal medicine: insights from a focus-group study in Germany. BMC Complement Altern Med 18, 92 (2018). https://doi.org/10.1186/s12906-018-2160-6.Search in Google Scholar

7Peltzer K, Pengpid S. Prevalence and determinants of traditional, complementary and alternative medicine provider use among adults from 32 countries. Chin J Integr Med. 2018;24(8):584–90.Search in Google Scholar

8Kolstad A, et al. Use of complementary and alternative therapies: a national multicentre study of oncology health professionals in Norway. Support Care Cancer. 2004;12(5):312–8.Search in Google Scholar

9Manek NJ, et al. What rheumatologists in the United States think of complementary and alternative medicine: results of a national survey. BMC Complement Altern Med. 2010;10:5.Search in Google Scholar

10Trimborn A, et al. Attitude of employees of a university clinic to complementary and alternative medicine in oncology. Ann Oncol. 2013;24(10):2641–5.Search in Google Scholar

11Wachtel-Galor S, Benzie IFF. Herbal Medicine: An Introduction to Its History, Usage, Regulation, Current Trends, and Research Needs. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/ Taylor & Francis; 2011. Chapter 1. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92773/Search in Google Scholar

12Patridge E., Gareiss P., Kinch M.S., Hoyer D. An analysis of FDA-approved drugs: Natural products and their derivatives. Drug Discovery Today. 2016;21(2):204–207. doi: 10.1016/j.drudis.2015.01.009.Open DOISearch in Google Scholar

13Silenzio VM. What is the role of complementary and alternative medicine in public health? Am J Public Health. 2002 Oct;92(10):1562-4. doi: 10.2105/ajph.92.10.1562. PMID: 12356590; PMCID: PMC1447277.Open DOISearch in Google Scholar

14Ernst E. The role of complementary and alternative medicine. BMJ. 2000 Nov 4;321(7269):1133-5. doi: 10.1136/bmj.321.7269.1133. PMID: 11061738; PMCID: PMC1118903.Open DOISearch in Google Scholar

15Bonham-Corcoran M, Armstrong A, O’Briain A, Cassidy A, Turner N. “The benefits of nature-based therapy for the individual and the environment: an integrative review”, Irish Journal of Occupational Therapy, 2022;50(1):16-27. https://doi.org/10.1108/IJOT-06-2021-0015Search in Google Scholar

16Tarasiuk A, Mosińska P, Fichna J. Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders. Chin Med. 2018 Jul 18;13:39. doi: 10.1186/s13020-018-0197-6. PMID: 30034512; PMCID: PMC6052535.Open DOISearch in Google Scholar

17Peterson CT, Denniston K, Chopra D. Therapeutic Uses of Triphala in Ayurvedic Medicine. J Altern Complement Med. 2017 Aug;23(8):607-614. doi: 10.1089/acm.2017.0083. Epub 2017 Jul 11. PMID: 28696777; PMCID: PMC5567597.Open DOISearch in Google Scholar

18Belapurkar P, Goyal P, Tiwari-Barua P. Immunomodulatory effects of triphala and its individual constituents: a review. Indian J Pharm Sci. 2014 Nov-Dec;76(6):467-75. PMID: 25593379; PMCID: PMC4293677.Search in Google Scholar

19Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J Tradit Complement Med. 2014 Dec 23;5(1):21-6. doi: 10.1016/j.jtcme.2014.10.006. PMID: 26151005; PMCID: PMC4488101.Open DOISearch in Google Scholar

20Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020 Mar 13;25(6):1324. doi: 10.3390/molecules25061324. PMID: 32183224; PMCID: PMC7144722.Open DOISearch in Google Scholar

21Retiu A, Budescu T, Menae I. Aloe Vera Extract for Stomach Acid Use Safe and Effective Treatment. Int. j. adv. res. rev. 2012;2(2):59-64. DOI: https://doi.org/10.47667/ijpasr.v2i2.125Search in Google Scholar

22Guo X, Mei N. Aloe vera: A review of toxicity and adverse clinical effects. J Environ Sci Health C Environ CarcinogEcotoxicol Rev. 2016 Apr 2;34(2):77-96. doi: 10.1080/10590501.2016.1166826. PMID: 26986231; PMCID: PMC6349368.Open DOISearch in Google Scholar

23Lim TK. Glycyrrhizaglabra. Edible Medicinal and Non-Medicinal Plants. 2015 Oct 22:354–457. doi: 10.1007/978-94-017-7276-1_18. PMCID: PMC7122586.Open DOISearch in Google Scholar

24Kumar SN, Nair SA, Nair MA, Murali M. Pharmacological and therapeutic effects of triphala – A literature review. Journal of Pharmacognosy and Phytochemistry 2016; 5(3): 23-27Search in Google Scholar

25Srikumar R, Parthasarathy N, Manikandan S, Narayanan G, Sheeladevi R. Effect of Triphala on Oxidative stress and on cellmediated immune response against noise stress in rats. Molecular Cell Biochemistry. 2006; 283:67-74.Search in Google Scholar

26Kaur S, Michael H, Arora S, Harkonen P, Kumar S. The in vitro Cytotoxic and apoptotic activity of Triphala- an Indian herbal drug. Journal of Ethnopharmacology. 2005; 9(1):15-20.Search in Google Scholar

27Lee HS, et al.. Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro. Biol Pharm Bull 2005;28:1639–1644Search in Google Scholar

28Pulok K, Mukherjee SR, Bhattacharyya S, et al.. Clinical study of ‘Triphala’—A well known-phytomedicine from India. Iran J Pharmacol-Ther 2005;5:51–54Search in Google Scholar

29Mehmood MH, Siddiqi HS, Gilani AH. The anti-diarrheal and spasmolytic activities of Phyllanthusemblica are mediated through dual blockade of muscarinic receptors and Ca2+ channels. J Ethnopharmacol. 2010;133:856–865. doi: 10.1016/j.jep.2010.11.023.Open DOISearch in Google Scholar

30Tarasiuk A, Mosińska P, Fichna J. Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders. Chin Med. 2018 Jul 18;13:39. doi: 10.1186/s13020-018-0197-6. PMID: 30034512; PMCID: PMC6052535.Open DOISearch in Google Scholar

31Nariya MB, Shukla VJ, Ravishankar B, Jain SM. Comparison of Gastroprotective Effects of Triphala Formulations on Stress-induced Ulcer in Rats. Indian J Pharm Sci. 2011 Nov;73(6):682-7. doi: 10.4103/0250-474X.100252. PMID: 23112406; PMCID: PMC3480757.Open DOISearch in Google Scholar

32Babaee N, Zabihi E, Mohseni S, Moghadamnia AA. Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis. Dent Res J (Isfahan). 2012;9:381e385.Search in Google Scholar

33Memedov NA, Egamberdieva D. Phytochemical Constituents and Pharmacological Effects of Licirice: AReview. In: OzturkM, Hakeem > 9eds) Plant and Human Health. 2019; Vol 3. Springer. Cham. https://doi.org/10.1007/978-3-030-04408-4_1Search in Google Scholar

34Ding Y, Brand E, Wang W, Zhao Z. Licorice: Resources, applications in ancient and modern times. J. Ethnopharmacol. 2022 Vol 298: 115594. https://doi.org/10.1016/j.jep.2022.115594.Search in Google Scholar

35Bennett A, Clark-Wibberley T, Stamford IF, Wright JE (1980) Aspirin-induced gastric mucosal damage in rats: cimetidine and deglycyrrhizinatedliquorice together give greater protection than low doses of either drug alone. J Pharm Pharmacol 32:151Search in Google Scholar

36Van Marle J, Aarsen PN, Lind A, van Weeren Kramer J (1981) Deglycyrrhizinisedliquorice (DGL) and the renewal of rat stomach epithelium. Eur J Pharmacol 72:219–225Search in Google Scholar

37Masoomeh MJ, Kiarash G (2007) In vitro susceptibility of Helicobacter pylori to licorice extract. Iran J Pharm Res 6:69–72Search in Google Scholar

38Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163.Open DOISearch in Google Scholar

39Schwalfenberg GK, Genuis SJ. The Importance of Magnesium in Clinical Healthcare. Scientifica (Cairo). 2017;2017:4179326. doi: 10.1155/2017/4179326. Epub 2017 Sep 28.Open DOISearch in Google Scholar