<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction</bold>: Growth failure is a common consequence in small for gestational age (SGA) children.<bold>Patients and Methods</bold>: The growth patterns and serum insulin like growth factor 1 (IGF1) concentrations before and after the 1st year under growth hormone treatment of 32 short stature SGA born children have been evaluated. In addition, we investigated the insulin like growth factor 1 receptor (IGF1R) exon 2 as a hotspot for IGF1R genetic alterations. It is of note that no dysmorphic features were observed in this group of children.<bold>Results</bold>: The tests for pituitary reserve were within normal ranges for all 32 patients. Growth hormone (GH) treatment (0.037 mg/kg/day) was initiated at the mean age of 9.32±3.19 years. Growth velocity increased yearly from −1.80 SDS after the first year to −0.03 SDS in the sixth year of treatment. Their IGF1 serum concentrations before treatment were age and sex appropriate, while during treatment a significant increase was observed fitting in the upper third of the normal range: before the treatment IGF1 SDS was 0.84±1.78 after 1st year the concentrations increased to IGF1 SDS 0.94±2.23. No genetic alterations were found in the IGF1R exon 2 by PCR analysis.<bold>Conclusions</bold>: Herein we present 32 short stature SGA children with no dysmorphic features treated with GH. They all had increased growth velocity and entered the normal growth range on their growth charts. No side-effects were observed. GH treatment in children with no genetic alterations on the IGF1R exon 2 is safe and efficient in treating SGA children with short stature.</abstract>

Introduction: Growth failure is a common consequence in small for gestational age (SGA) children.Patients and Methods: The growth patterns and serum insulin like growth factor 1 (IGF1) concentrations before and after the 1st year under growth hormone treatment of 32 short stature SGA born children have been evaluated. In addition, we investigated the insulin like growth factor 1 receptor (IGF1R) exon 2 as a hotspot for IGF1R genetic alterations. It is of note that no dysmorphic features were observed in this group of children.Results: The tests for pituitary reserve were within normal ranges for all 32 patients. Growth hormone (GH) treatment (0.037 mg/kg/day) was initiated at the mean age of 9.32±3.19 years. Growth velocity increased yearly from −1.80 SDS after the first year to −0.03 SDS in the sixth year of treatment. Their IGF1 serum concentrations before treatment were age and sex appropriate, while during treatment a significant increase was observed fitting in the upper third of the normal range: before the treatment IGF1 SDS was 0.84±1.78 after 1st year the concentrations increased to IGF1 SDS 0.94±2.23. No genetic alterations were found in the IGF1R exon 2 by PCR analysis.Conclusions: Herein we present 32 short stature SGA children with no dysmorphic features treated with GH. They all had increased growth velocity and entered the normal growth range on their growth charts. No side-effects were observed. GH treatment in children with no genetic alterations on the IGF1R exon 2 is safe and efficient in treating SGA children with short stature.

Growth Hormone Treatment in Children Born Small for Gestational Age (SGA)

University Children’s Hospital, Medical Faculty Skopje

PRILOZI

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Growth Hormone Treatment in Children Born Small for Gestational Age (SGA)"}

Introduction: Growth failure is a common consequence in small for gestational age (SGA) children.Patients and Methods: The growth patterns and serum insulin...

Growth Hormone Treatment in Children Born Small for Gestational Age (SGA)

Published Online: Aug 13, 2018

Page range: 143 - 149

DOI: https://doi.org/10.2478/prilozi-2018-0034

Keywords
small for gestational age, short stature, IGF1, insulin like growth factor 1 receptor, growth hormone treatment

© 2018 Aleksandra Janchevska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Growth Hormone Treatment in Children Born Small for Gestational Age (SGA)

Published Online: Aug 13, 2018

Page range: 143 - 149

DOI: https://doi.org/10.2478/prilozi-2018-0034

Keywordssmall for gestational age, short stature, IGF1, insulin like growth factor 1 receptor, growth hormone treatment

© 2018 Aleksandra Janchevska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
small for gestational age, short stature, IGF1, insulin like growth factor 1 receptor, growth hormone treatment