<abstract xmlns="http://www.w3.org/1999/xhtml">Four different compositions of polylactide/thermoplastic starch blends (PLA/TPS blends) for application as drug carriers were examined. Initially, using cyanocobalamin (1.355 kDa) as a model compound, the blend with the highest starch content (wt. 60%) was selected for further research of mass transfer phenomenon. In this case, different concentrations of acetaminophen (0.151 kDa), doxorubicin hydrochloride (0.580 kDa) and cyanocobalamin (1.355 kDa) were used for determination of particular releasing profiles. Besides from the comparative analysis of obtained results, the values of the overall mass transfer coefficient (K) were calculated for each of tested drug molecules. Depending on the size and properties of used compound, determined values of the coefficient range from 10−11 to 10−13 m/s. Based on these outcomes, it could be stated that PLA/TPS blend selected in preliminary research, seems to be preferred material for fabrication of long-term drug delivery systems, which could be successfully applied for example in anti-cancer therapy.</abstract>

Four different compositions of polylactide/thermoplastic starch blends (PLA/TPS blends) for application as drug carriers were examined. Initially, using cyanocobalamin (1.355 kDa) as a model compound, the blend with the highest starch content (wt. 60%) was selected for further research of mass transfer phenomenon. In this case, different concentrations of acetaminophen (0.151 kDa), doxorubicin hydrochloride (0.580 kDa) and cyanocobalamin (1.355 kDa) were used for determination of particular releasing profiles. Besides from the comparative analysis of obtained results, the values of the overall mass transfer coefficient (K) were calculated for each of tested drug molecules. Depending on the size and properties of used compound, determined values of the coefficient range from 10−11 to 10−13 m/s. Based on these outcomes, it could be stated that PLA/TPS blend selected in preliminary research, seems to be preferred material for fabrication of long-term drug delivery systems, which could be successfully applied for example in anti-cancer therapy.

Biodegradable polylactide and thermoplastic starch blends as drug release device – mass transfer study

Wroclaw University of Science and Technology

Division of Bioprocess and Biomedical Engineering, Faculty of Chemistry

New Chemical Syntheses Institute, Department of Organic Technologies

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Four different compositions of polylactide/thermoplastic starch blends (PLA/TPS blends) for application as drug carriers were examined. Initially, using...

Biodegradable polylactide and thermoplastic starch blends as drug release device – mass transfer study

Published Online: Apr 16, 2018

Page range: 75 - 80

DOI: https://doi.org/10.2478/pjct-2018-0011

Keywords
polylactide/thermoplastic starch (PLA/TPS) blends, permeability, local drug release, overall mass transport coefficient

© 2018 Karolina Labus et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Biodegradable polylactide and thermoplastic starch blends as drug release device – mass transfer study

Published Online: Apr 16, 2018

Page range: 75 - 80

DOI: https://doi.org/10.2478/pjct-2018-0011

Keywordspolylactide/thermoplastic starch (PLA/TPS) blends, permeability, local drug release, overall mass transport coefficient

© 2018 Karolina Labus et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
polylactide/thermoplastic starch (PLA/TPS) blends, permeability, local drug release, overall mass transport coefficient