<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The premotor phase of Parkinson’s disease (PD) precedes the appearance of motor symptoms by years. Many non-motor diseases have been associated with an increased risk of developing PD, but results of these studies are conflicting. The aim of this study was to investigate the occurrence of certain internal diseases (metabolic, circulatory, gastrointestinal) based on diagnosis codes, before the diagnosis of PD. There were 5209 patients included in the study who received diagnosis of PD at least in 2 years and we analyzed data retrospectively between 2004 and 2016. Out of metabolic diseases dyslipidemia (41%) and diabetes mellitus (32%), out of circulatory diseases hypertension (89%) and ischemic heart disease (51%) and out of gastrointestinal diseases gastroesophageal reflux disease (51%) and gallstones (25%) were the first two most common disorders in the examined PD patients. This is the first study in Hungary which analyzed PD in a large database in the context of internal diseases, and raised the possibility of a link between dyslipidemias, diabetes mellitus, hypertension, ischemic heart disease, gastooesophagial reflux, gallstones and PD.</p></abstract>

The premotor phase of Parkinson’s disease (PD) precedes the appearance of motor symptoms by years. Many non-motor diseases have been associated with an increased risk of developing PD, but results of these studies are conflicting. The aim of this study was to investigate the occurrence of certain internal diseases (metabolic, circulatory, gastrointestinal) based on diagnosis codes, before the diagnosis of PD. There were 5209 patients included in the study who received diagnosis of PD at least in 2 years and we analyzed data retrospectively between 2004 and 2016. Out of metabolic diseases dyslipidemia (41%) and diabetes mellitus (32%), out of circulatory diseases hypertension (89%) and ischemic heart disease (51%) and out of gastrointestinal diseases gastroesophageal reflux disease (51%) and gallstones (25%) were the first two most common disorders in the examined PD patients. This is the first study in Hungary which analyzed PD in a large database in the context of internal diseases, and raised the possibility of a link between dyslipidemias, diabetes mellitus, hypertension, ischemic heart disease, gastooesophagial reflux, gallstones and PD.

Occurrence of internal diseases in the premotor phase of Parkinson’s disease by analyzing a large database covering a whole population

Bulletin of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The premotor phase of Parkinson’s disease (PD) precedes the appearance of motor symptoms by years. Many non-motor diseases have been associated with an...

Occurrence of internal diseases in the premotor phase of Parkinson’s disease by analyzing a large database covering a whole population

Published Online: Feb 13, 2020

Page range: 35 - 41

Received: Jul 11, 2019

Accepted: Oct 23, 2019

DOI: https://doi.org/10.2478/orvtudert-2019-0009

Keywords
Parkinson’s disease, internal disease, big data, Hungary

© 2019 Szatmári Szabolcs et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Occurrence of internal diseases in the premotor phase of Parkinson’s disease by analyzing a large database covering a whole population

Published Online: Feb 13, 2020

Page range: 35 - 41

Received: Jul 11, 2019

Accepted: Oct 23, 2019

DOI: https://doi.org/10.2478/orvtudert-2019-0009

KeywordsParkinson’s disease, internal disease, big data, Hungary

© 2019 Szatmári Szabolcs et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Parkinson’s disease, internal disease, big data, Hungary