<abstract xmlns="http://www.w3.org/1999/xhtml"><italic>Background and objectives</italic>: This study describes the treatment planning and dose delivery methods of radiotherapy for patients undergoing bone marrow transplantation. The analysis was carried out in the context of the evolution of these methods over the last 60 years.<italic>Materials and methods</italic>: A systematic literature search was carried out using the PubMed search engine. Overall, 90 relevant studies were included: 24 general studies, 10 describing isotopes usage, 24 related to conventional and 32 to advanced methods.<italic>Results</italic>: The analysis of the evolution of radiotherapy methods shows how significantly the precision of dose planning methods and its delivery have changed. The atypical positioning caused by geometrical requirements for applications of isotopes or conventional techniques has been replaced by positioning on a therapeutic couch, which allows a more precise setup of the patient that is necessary for an exact delivery of the planned dose. The dose can be fully optimized and calculated on tomographic images by algorithms implemented in planning systems. Optimization process allows to reduce doses in organs at risk. The accuracy between planned and delivered doses can be checked by pretreatment verification methods, and the patient positioning can be checked by image guidance procedures.<italic>Interpretation and conclusions</italic>: Current radiotherapy solutions allow a precise delivery of doses to the planning target volume while reducing doses to organs at risk. Nevertheless, it should be kept in mind that establishing radiotherapy as an important element of the whole therapeutic regimen resulted from the follow-up of patients treated by conventional techniques. To confirm the clinical value of new advanced techniques, clinical trials are required.</abstract>

Background and objectives: This study describes the treatment planning and dose delivery methods of radiotherapy for patients undergoing bone marrow transplantation. The analysis was carried out in the context of the evolution of these methods over the last 60 years.Materials and methods: A systematic literature search was carried out using the PubMed search engine. Overall, 90 relevant studies were included: 24 general studies, 10 describing isotopes usage, 24 related to conventional and 32 to advanced methods.Results: The analysis of the evolution of radiotherapy methods shows how significantly the precision of dose planning methods and its delivery have changed. The atypical positioning caused by geometrical requirements for applications of isotopes or conventional techniques has been replaced by positioning on a therapeutic couch, which allows a more precise setup of the patient that is necessary for an exact delivery of the planned dose. The dose can be fully optimized and calculated on tomographic images by algorithms implemented in planning systems. Optimization process allows to reduce doses in organs at risk. The accuracy between planned and delivered doses can be checked by pretreatment verification methods, and the patient positioning can be checked by image guidance procedures.Interpretation and conclusions: Current radiotherapy solutions allow a precise delivery of doses to the planning target volume while reducing doses to organs at risk. Nevertheless, it should be kept in mind that establishing radiotherapy as an important element of the whole therapeutic regimen resulted from the follow-up of patients treated by conventional techniques. To confirm the clinical value of new advanced techniques, clinical trials are required.

Evolution of treatment planning and dose delivery methods during radiotherapy for patients undergoing bone marrow transplantation: a review

Medical Physics Department, Greater Poland Cancer Centre

Nukleonika

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background and objectives: This study describes the treatment planning and dose delivery methods of radiotherapy for patients undergoing bone marrow...

Evolution of treatment planning and dose delivery methods during radiotherapy for patients undergoing bone marrow transplantation: a review

Published Online: Mar 20, 2020

Page range: 19 - 30

Received: May 17, 2019

Accepted: Oct 10, 2019

DOI: https://doi.org/10.2478/nuka-2020-0003

Keywords
Total body irradiation, Total marrow irradiation, TBI/TMI planning, TBI/TMI dose delivery

© 2020 Joanna Litoborska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Evolution of treatment planning and dose delivery methods during radiotherapy for patients undergoing bone marrow transplantation: a review

Published Online: Mar 20, 2020

Page range: 19 - 30

Received: May 17, 2019

Accepted: Oct 10, 2019

DOI: https://doi.org/10.2478/nuka-2020-0003

KeywordsTotal body irradiation, Total marrow irradiation, TBI/TMI planning, TBI/TMI dose delivery

© 2020 Joanna Litoborska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Total body irradiation, Total marrow irradiation, TBI/TMI planning, TBI/TMI dose delivery