Retrospective Study on Trilostane Titration Dose Treatment in Dogs with Terminal Stage of Hyperadrenocorticism

1 Feldman, E.C., Nelson, R.W. (2004). Canine hyperadrenocorticism Cushings syndrome. In: Canine and Feline Endocrinology and Reproduction (p. 252). Elsevier Health Sciences. Search in Google Scholar

2 Kritsepi-Konstantinou, M., Oikonomidis, I.L. (2016). The interpretation of leukogram in dog and cat. HJCAM 5(2): 63. Search in Google Scholar

3 Ryad, N.M., Ramadan, E.S., Salem, N.Y., Saleh, I.A. (2021). Influence of dexamethasone administration on hematology, biochemistry, and thyroid hormones in dogs. Adv Anim Vet Sci. 9(1): 111-116. https://doi.org/10.17582/journal.aavs/2021/9.1.111.116 Search in Google Scholar

4 Peterson, M.E. (2007). Diagnosis of hyperadrenocorticism in dogs. Clin Tech Small Anim Pract. 22(1): 2-11. https://doi.org/10.1053/j.ctsap.2007.02.007 PMid:17542191 Search in Google Scholar

5 Behrend, E.N., Kooistra, H.S., Nelson, R., Reusch, C.E., Scott‐Moncrieff, J.C. (2013). Diagnosis of spontaneous canine hyperadrenocorticism: 2012 ACVIM consensus statement (small animal). J Vet Intern Med. 27(6): 1292-1304. https://doi.org/10.1111/jvim.12192 PMid:24112317 Search in Google Scholar

6 Potts, G.O., Creange, J.E., Harding, H.R., Schane, H.P. (1978). Trilostane, an orally active inhibitor of steroid biosynthesis. Steroids 32(2): 257-267. https://doi.org/10.1016/0039-128X(78)90010-7 PMid:715820 Search in Google Scholar

7 Eastwood, J.M., Elwood, C.M., Hurley, K.J. (2003). Trilostane treatment of a dog with functional adrenocortical neoplasia. J Small Anim Pract. 44(3): 126-131. https://doi.org/10.1111/j.1748-5827.2003.tb00133.x PMid:12653328 Search in Google Scholar

8 Neiger, R., Hurley, K.J., Ramsey, I., O’Connor, J., Mooney, C.T. (2002). Trilostane treatment of 78 dogs with pituitary‐dependent hyperadrenocorticism. Vet Rec. 150(26): 799-804. https://doi.org/10.1136/vr.150.26.799 PMid:12120922 Search in Google Scholar

9 Lemetayer, J., Blois, S. (2018). Update on the use of trilostane in dogs. Can Vet J. 59(4): 397-407. Search in Google Scholar

10 Bell, R., Neiger, R., McGrotty, Y., Ramsey, I.K. (2006). Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs. Vet Rec. 159(9): 277-281. https://doi.org/10.1136/vr.159.9.277 PMid:16946310 Search in Google Scholar

11 Vaughan, M.A., Feldman, E.C., Hoar, B.R., Nelson, R.W. (2008). Evaluation of twice-daily, low-dose trilostane treatment administered orally in dogs with naturally occurring hyperadrenocor ticism. J Am Vet Med Assoc. 232(9): 1321-1328. https://doi.org/10.2460/javma.232.9.1321 PMid:18447776 Search in Google Scholar

12 Feldman, E.C. (2011). Evaluation of twice-daily lower-dose trilostane treatment administered orally in dogs with naturally occurring hyperadrenocorticism. J Am Vet Med Assoc. 238(11): 1441-1451. https://doi.org/10.2460/javma.238.11.1441 PMid:21627507 Search in Google Scholar

13 Teshima, T., Hara, Y., Takekoshi, S., Nezu, Y., Harada, Y., Yogo, T., Teramoto, A., Osaamura, R.Y., Tagawa, M. (2009). Trilostane-induced inhibition of cortisol secretion results in reduced negative feedback at the hypothalamic-pituitary axis. Domest Anim Endocrinol. 36(1): 32-44. https://doi.org/10.1016/j.domaniend.2008.10.002 PMid:19041802 Search in Google Scholar

14 Gilor, C., Graves, T.K. (2011). Interpretation of laboratory tests for canine Cushing’s syndrome. Top Companion Anim Med. 26(2): 98-108. https://doi.org/10.1053/j.tcam.2011.03.001 PMid:21596349 Search in Google Scholar

15 Fathman, L. (2005). Textbook of veterinary internal medicine. Elsevier Saunders Search in Google Scholar

16 Jacoby, R.C., Owings, J.T., Ortega, T., Gosselin, R., Feldman, E.C. (2001). Biochemical basis for the hypercoagulable state seen in Cushing syndrome; discussion 1006-7. Arch Surg. 136(9): 1003-1006. https://doi.org/10.1001/archsurg.136.9.1003 PMid:11529821 Search in Google Scholar

17 Galac, S. (2010). Recent developments in canine Cushings syndrome. Utrecht University Search in Google Scholar

18 Cho, K.D., Kang, J.H., Chang, D., Na, K.J., Yang, M.P. (2013). Efficacy of low‐ and high‐dose trilostane treatment in dogs (<5 kg) with pituitary‐dependent hyperadrenocorticism. J Vet Intern Med. 27(1): 91-98. https://doi.org/10.1111/jvim.12007 PMid:23167780 Search in Google Scholar

19 Ettinger, S.J., Feldman, E.C. (2010). Textbook of veterinary internal medicine. 7th edition, 2086-2088. Search in Google Scholar

20 Alenza, D.P., Arenas, C., Lopez, M.L., Melian, C. (2006). Long-term efficacy of trilostane administered twice daily in dogs with pituitary-dependent hyperadrenocorticism. J Am Anim Hosp Assoc. 42(4): 269-276. https://doi.org/10.5326/0420269 PMid:16822765 Search in Google Scholar