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Effect of Curcuma longa maceration treatment on ovarian follicular development, serum oestradiol, uterine growth and vascularisation in female albino rats

Andriyanto Andriyanto
Andriyanto Andriyanto
, 
Hamdika Yendri Putra
Hamdika Yendri Putra
, 
Mawar Subangkit
Mawar Subangkit
, 
Elpita Tarigan
Elpita Tarigan
, 
Leliana Nugrahaning Widi
Leliana Nugrahaning Widi
, 
Yusa Irarang
Yusa Irarang
, 
Wasmen Manalu
Wasmen Manalu
 and 
Amaq Fadholly
Amaq Fadholly
   | Apr 04, 2024
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Published Online: Apr 04, 2024
Page range: -
Received: Oct 03, 2023
Accepted: Mar 25, 2024
DOI: https://doi.org/10.2478/jvetres-2024-0020
Keywords
© 2024 Andriyanto Andriyanto et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1.

The uterine (A) and ovary (B) relative weight of experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; * – significant difference compared to the control group (P-value < 0.05); ns – non significant
The uterine (A) and ovary (B) relative weight of experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; * – significant difference compared to the control group (P-value < 0.05); ns – non significant

Fig. 2.

Diameter (A), length (B), and vascularisation (C) of uterus in experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; NS/ns – non significant
Diameter (A), length (B), and vascularisation (C) of uterus in experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; NS/ns – non significant

Fig. 3.

Gross pathology of the uterus and its vascularisation in experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)
Gross pathology of the uterus and its vascularisation in experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)

Fig. 4.

Histopathological visualisation showing the effect of 20 days’ Curcuma longa maceration administration on the uterine gland of experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)
Histopathological visualisation showing the effect of 20 days’ Curcuma longa maceration administration on the uterine gland of experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)

Fig. 5.

Histopathological visualisation showing the effect of 20 days’ Curcuma longa maceration administration on the follicles of experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)
Histopathological visualisation showing the effect of 20 days’ Curcuma longa maceration administration on the follicles of experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)

Fig. 6.

Immunohistochemical staining showing the effect of 20 days’ Curcuma longa maceration administration on the expression of ovarian vascular endothelial growth factor by experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)
Immunohistochemical staining showing the effect of 20 days’ Curcuma longa maceration administration on the expression of ovarian vascular endothelial growth factor by experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)

Fig. 7.

Serum follicle-stimulating hormone (FSH) (A), oestradiol (B) and progesterone (C) concentrations in experimental female Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; * – significant difference compared to the control group (P-value < 0.05); ns – non significant
Serum follicle-stimulating hormone (FSH) (A), oestradiol (B) and progesterone (C) concentrations in experimental female Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; * – significant difference compared to the control group (P-value < 0.05); ns – non significant
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