<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2020-0017_s_005">
<h3>Introduction</h3>
<p>Sheep pulmonary adenomatosis (ovine pulmonary adenomatosis, OPA, Jaagsiekte) is a chronic contagious bronchoalveolar carcinoma caused by the Jaagsiekte sheep retrovirus. Since effective treatment and a vaccination procedure are not currently possible, control and eradication of the disease is difficult. It leads to serious economic losses around the world, therefore studies are currently underway in order to design control and eradication programmes. In this study, levels and changes in selected tumour markers (carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA 19-9, CA 15-3, and alphafetoprotein (AFP)-3) and their diagnostic significance were investigated.</p></sec>
<sec id="j_jvetres-2020-0017_s_006">
<h3>Material and Methods</h3>
<p>A total of 30 sheep were used. Clinical examinations were performed and blood samples were obtained before slaughter from all animals with presumed OPA. Blood samples with positive OPA results by macroscopic and histopathological examination were included in the study as the experimental group and numbered 20. Sheep totalling 10 had negative OPA results and provided control samples.</p></sec>
<sec id="j_jvetres-2020-0017_s_007">
<h3>Results</h3>
<p>CEA levels were similar in both groups, and the differences were statistically insignificant (P > 0.05). CA 125, CA 19-9, CA 15-3, and AFP-3 levels were higher in the OPA group than the control group and with statistical significance (P &lt; 0.05). In all OPA animals, CA 125 levels were higher than 1 U/mL.</p></sec>
<sec id="j_jvetres-2020-0017_s_008">
<h3>Conclusion</h3>
<p>serum CAs and AFP levels increase significantly in adenomatous sheep. These tumour markers are thought to facilitate the diagnosis of OPA.</p></sec>
</abstract>

Introduction
Sheep pulmonary adenomatosis (ovine pulmonary adenomatosis, OPA, Jaagsiekte) is a chronic contagious bronchoalveolar carcinoma caused by the Jaagsiekte sheep retrovirus. Since effective treatment and a vaccination procedure are not currently possible, control and eradication of the disease is difficult. It leads to serious economic losses around the world, therefore studies are currently underway in order to design control and eradication programmes. In this study, levels and changes in selected tumour markers (carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA 19-9, CA 15-3, and alphafetoprotein (AFP)-3) and their diagnostic significance were investigated.

Material and Methods
A total of 30 sheep were used. Clinical examinations were performed and blood samples were obtained before slaughter from all animals with presumed OPA. Blood samples with positive OPA results by macroscopic and histopathological examination were included in the study as the experimental group and numbered 20. Sheep totalling 10 had negative OPA results and provided control samples.

Results
CEA levels were similar in both groups, and the differences were statistically insignificant (P > 0.05). CA 125, CA 19-9, CA 15-3, and AFP-3 levels were higher in the OPA group than the control group and with statistical significance (P < 0.05). In all OPA animals, CA 125 levels were higher than 1 U/mL.

Conclusion
serum CAs and AFP levels increase significantly in adenomatous sheep. These tumour markers are thought to facilitate the diagnosis of OPA.

Selected tumour biomarker levels in sheep with pulmonary adenomatosis

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Selected tumour biomarker levels in sheep with pulmonary adenomatosis"}

Introduction
Sheep pulmonary adenomatosis (ovine pulmonary adenomatosis, OPA, Jaagsiekte) is a chronic contagious bronchoalveolar carcinoma caused by the...

Selected tumour biomarker levels in sheep with pulmonary adenomatosis

Published Online: Mar 08, 2020

Page range: 39 - 44

Received: Jul 07, 2019

Accepted: Feb 21, 2020

DOI: https://doi.org/10.2478/jvetres-2020-0017

Keywords
sheep, pulmonary adenomatosis, tumour biomarkers, diagnosis

© 2020 C. Özkan et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Selected tumour biomarker levels in sheep with pulmonary adenomatosis

Published Online: Mar 08, 2020

Page range: 39 - 44

Received: Jul 07, 2019

Accepted: Feb 21, 2020

DOI: https://doi.org/10.2478/jvetres-2020-0017

Keywordssheep, pulmonary adenomatosis, tumour biomarkers, diagnosis

© 2020 C. Özkan et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
sheep, pulmonary adenomatosis, tumour biomarkers, diagnosis