<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction:</bold> Statins are pharmacological agents commonly used to lower serum cholesterol level. The aim of the experiment was to investigate the effect of the statin simvastatin on thrombopoiesis in the porcine model because it is the closest to the human one regarding physiological and genetic similarities.<bold>Material and Methods:</bold> The study was conducted on a group of 32 pigs randomly divided into two equal groups: control and experimental. The pigs were treated for 28 and 56 days with simvastatin in a dose of 40 mg per day per animal. Cytological evaluation of bone marrow smears was performed to assess the average number of all types of cells during thrombopoiesis as was analysis of haematological parameters to assess PLT and MPV.<bold>Results:</bold> During the course of the experiment statistically significant changes in the number of promegakaryocytes were observed. Other parameters also showed some fluctuations during the study. However, these changes were not statistically significant.<bold>Conclusion:</bold> The obtained results clearly indicate a toxic influence of simvastatin on the process of thrombopoiesis and prove that statins reduce mean platelet volume, thus affecting the process of clot formation through the period of administration in a duration-dependent manner.</abstract>

Introduction: Statins are pharmacological agents commonly used to lower serum cholesterol level. The aim of the experiment was to investigate the effect of the statin simvastatin on thrombopoiesis in the porcine model because it is the closest to the human one regarding physiological and genetic similarities.Material and Methods: The study was conducted on a group of 32 pigs randomly divided into two equal groups: control and experimental. The pigs were treated for 28 and 56 days with simvastatin in a dose of 40 mg per day per animal. Cytological evaluation of bone marrow smears was performed to assess the average number of all types of cells during thrombopoiesis as was analysis of haematological parameters to assess PLT and MPV.Results: During the course of the experiment statistically significant changes in the number of promegakaryocytes were observed. Other parameters also showed some fluctuations during the study. However, these changes were not statistically significant.Conclusion: The obtained results clearly indicate a toxic influence of simvastatin on the process of thrombopoiesis and prove that statins reduce mean platelet volume, thus affecting the process of clot formation through the period of administration in a duration-dependent manner.

Effect of simvastatin on thrombopoiesis in porcine bone marrow

Department and Clinic of Internal Diseases, Faculty of Veterinary Medicine

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Effect of simvastatin on thrombopoiesis in porcine bone marrow"}

Introduction: Statins are pharmacological agents commonly used to lower serum cholesterol level. The aim of the experiment was to investigate the effect of the...

Effect of simvastatin on thrombopoiesis in porcine bone marrow

Published Online: Mar 28, 2019

Page range: 117 - 121

Received: Aug 12, 2018

Accepted: Feb 12, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0007

Keywords
swine, simvastatin, bone marrow, haematopoiesis, thrombopoiesis

© 2019 Anna Snarska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effect of simvastatin on thrombopoiesis in porcine bone marrow

Published Online: Mar 28, 2019

Page range: 117 - 121

Received: Aug 12, 2018

Accepted: Feb 12, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0007

Keywordsswine, simvastatin, bone marrow, haematopoiesis, thrombopoiesis

© 2019 Anna Snarska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
swine, simvastatin, bone marrow, haematopoiesis, thrombopoiesis