<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction:</bold> Breed predisposition to cutaneous mast cell tumours (MCT) in a population of dogs in Poland affected by various skin tumours was assessed, and the distribution of MCT characteristics such as histological grading, sex, age, and location, in predisposed breeds was evaluated.<bold>Material and Methods:</bold> The retrospective epidemiological study included 550 dogs affected by cutaneous MCTs with a reference group of 2,557 dogs diagnosed with other skin tumours.<bold>Results:</bold> A univariable logistic regression analysis was performed to determine the odds ratios (ORs) with 95% confidence intervals. The risk of high-grade MCTs was the highest for Shar-Peis (OR: 26.394) and American Staffordshire Terriers (OR: 2.897). Boxers (OR: 6.619), Labrador Retrievers (OR: 2.630), French Bulldogs (OR: 2.050), Golden Retrievers (OR: 1.949), and American Staffordshire Terriers (OR: 2.592) were mainly affected by low-grade MCTs. The high risk of MCT was calculated to be at the age of 4–6 years for Labrador Retrievers (OR: 2.686) and 7–10 years for Boxers (OR: 2.956) and French Bulldogs (OR: 9.429). MCTs were significantly more often located on the trunk in French Bulldogs (OR: 4.680), American Staffordshire Terriers (OR: 2.520), and Labrador Retrievers (OR: 1.948). There was no statistically significant correlation between gender and the occurrence of MCTs in the breeds.<bold>Conclusions:</bold> The breed-predicated differences in the clinical course of MCTs suggest a genetic background for the tumours.</abstract>

Introduction: Breed predisposition to cutaneous mast cell tumours (MCT) in a population of dogs in Poland affected by various skin tumours was assessed, and the distribution of MCT characteristics such as histological grading, sex, age, and location, in predisposed breeds was evaluated.Material and Methods: The retrospective epidemiological study included 550 dogs affected by cutaneous MCTs with a reference group of 2,557 dogs diagnosed with other skin tumours.Results: A univariable logistic regression analysis was performed to determine the odds ratios (ORs) with 95% confidence intervals. The risk of high-grade MCTs was the highest for Shar-Peis (OR: 26.394) and American Staffordshire Terriers (OR: 2.897). Boxers (OR: 6.619), Labrador Retrievers (OR: 2.630), French Bulldogs (OR: 2.050), Golden Retrievers (OR: 1.949), and American Staffordshire Terriers (OR: 2.592) were mainly affected by low-grade MCTs. The high risk of MCT was calculated to be at the age of 4–6 years for Labrador Retrievers (OR: 2.686) and 7–10 years for Boxers (OR: 2.956) and French Bulldogs (OR: 9.429). MCTs were significantly more often located on the trunk in French Bulldogs (OR: 4.680), American Staffordshire Terriers (OR: 2.520), and Labrador Retrievers (OR: 1.948). There was no statistically significant correlation between gender and the occurrence of MCTs in the breeds.Conclusions: The breed-predicated differences in the clinical course of MCTs suggest a genetic background for the tumours.

Occurrence and distribution of canine cutaneous mast cell tumour characteristics among predisposed breeds

Sub-Department of Pathomorphology and Forensic Veterinary Medicine, Department and Clinic of Animal Internal Diseases

Sub-Department of General and Molecular Genetics

Institute of Biological Basis of Animal Production, Faculty of Biology, Animal Sciences, and Bioeconomy, University of Life Sciences in Lublin

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction: Breed predisposition to cutaneous mast cell tumours (MCT) in a population of dogs in Poland affected by various skin tumours was assessed, and...

Occurrence and distribution of canine cutaneous mast cell tumour characteristics among predisposed breeds

Published Online: Mar 28, 2019

Page range: 141 - 148

Received: Sep 05, 2018

Accepted: Jan 10, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0002

Keywords
dogs, mast cell tumour, breed, predisposition

© 2019 Anna Śmiech et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Occurrence and distribution of canine cutaneous mast cell tumour characteristics among predisposed breeds

Published Online: Mar 28, 2019

Page range: 141 - 148

Received: Sep 05, 2018

Accepted: Jan 10, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0002

Keywordsdogs, mast cell tumour, breed, predisposition

© 2019 Anna Śmiech et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
dogs, mast cell tumour, breed, predisposition