<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jvetres-2018-0047_s_005_w2aab3b7c14b1b6b1aab1c16b1Aa"><h3>Introduction</h3><p>The study aimed to observe TNF-α serum concentration as well as changes in respiration rate, body temperature, and pulse rate in burn victims during 84 h post burn.</p></sec><sec id="j_jvetres-2018-0047_s_006_w2aab3b7c14b1b6b1aab1c16b2Aa"><h3>Material and Methods</h3><p>A total of 30 healthy pigs were divided into two groups: A, the test group and N, the control group. The experimental group suffered burns to 30% of the body surface, and after infliction of the burns both groups were closely monitored.</p></sec><sec id="j_jvetres-2018-0047_s_007_w2aab3b7c14b1b6b1aab1c16b3Aa"><h3>Results</h3><p>The biggest increase in TNF-α serum concentration in the test subjects occurred around the 6<sup>th</sup> h of the study, and the second biggest increase took place between 12<sup>th</sup> and 36<sup>th</sup> h. In the 36<sup>th</sup> h, TNF-α was 2.5 times more concentrated in serum in the test group than in the control group. In the test group, the biggest increase in respiration rate occurred up to the 6<sup>th</sup> h post burn, on average up to 29/min. In the 12<sup>th</sup> h post burn, the mean pulse rate in the test group was 133/min and dropped to the lowest value in the 72<sup>nd</sup> h of the experiment. A gradual increase in body temperature up to 41.72°C was observed up to the 30<sup>th</sup> h post burn and decreased to a significant value of 40.74°C by the 84<sup>th</sup> h of the study.</p></sec><sec id="j_jvetres-2018-0047_s_008_w2aab3b7c14b1b6b1aab1c16b4Aa"><h3>Conclusion</h3><p>In a period of a pronounced rise in TNF-α serum concentration, this parameter, pulse rate, and respiration rate are highly correlated and are also influenced by multiple inflammation forming factors.</p></sec></abstract>

IntroductionThe study aimed to observe TNF-α serum concentration as well as changes in respiration rate, body temperature, and pulse rate in burn victims during 84 h post burn.Material and MethodsA total of 30 healthy pigs were divided into two groups: A, the test group and N, the control group. The experimental group suffered burns to 30% of the body surface, and after infliction of the burns both groups were closely monitored.ResultsThe biggest increase in TNF-α serum concentration in the test subjects occurred around the 6th h of the study, and the second biggest increase took place between 12th and 36th h. In the 36th h, TNF-α was 2.5 times more concentrated in serum in the test group than in the control group. In the test group, the biggest increase in respiration rate occurred up to the 6th h post burn, on average up to 29/min. In the 12th h post burn, the mean pulse rate in the test group was 133/min and dropped to the lowest value in the 72nd h of the experiment. A gradual increase in body temperature up to 41.72°C was observed up to the 30th h post burn and decreased to a significant value of 40.74°C by the 84th h of the study.ConclusionIn a period of a pronounced rise in TNF-α serum concentration, this parameter, pulse rate, and respiration rate are highly correlated and are also influenced by multiple inflammation forming factors.

Effect of TNF-α concentration on selected clinical parameters of swine after burns

Department and Clinic of Animal Internal Diseases

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

IntroductionThe study aimed to observe TNF-α serum concentration as well as changes in respiration rate, body temperature, and pulse rate in burn victims...

		Study period
Correlation	0–36	36–84	0–84
TNF-α/pulse rate	0.498	−0.095	0.3943
TNF-α/respiration rate	0.5255	−0.3083	−0.0565
TNF-α/body temperature	0.7188	0.7494	0.4834

Effect of TNF-α concentration on selected clinical parameters of swine after burns

Published Online: Oct 23, 2018

Page range: 335 - 340

Received: Apr 29, 2018

Accepted: Sep 21, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0047

Keywords
burn injury, TNF-α, swine, systemic inflammatory response syndrome

© 2018 R. Aleksiewicz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Established dependencies and values of correlation coefficient (r) in study periods (group A)

Effect of TNF-α concentration on selected clinical parameters of swine after burns

Published Online: Oct 23, 2018

Page range: 335 - 340

Received: Apr 29, 2018

Accepted: Sep 21, 2018

DOI: https://doi.org/10.2478/jvetres-2018-0047

Keywordsburn injury, TNF-α, swine, systemic inflammatory response syndrome

© 2018 R. Aleksiewicz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Established dependencies and values of correlation coefficient (r) in study periods (group A)

Keywords
burn injury, TNF-α, swine, systemic inflammatory response syndrome