Bone mineral density in Canadian children with severe haemophilia A or B: a cross-sectional study
, , , and | Oct 14, 2021
About this article
Article Category: Clinical Research
Published Online: Oct 14, 2021
Page range: 111 - 118
DOI: https://doi.org/10.2478/jhp-2021-0012
Keywords
© 2021 Cecily Bos et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
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Participant characteristics
| N | 33 | 5 |
| Age (years, months) | 10.2 +/− 4.8 | 9.5 +/− 3.8 |
| Height (cm) | 140.1 +/− 25.2 | 142.6 +/−23.5 |
| Weight (kg) | 37.9 +/− 21.2 | 39.3 +/− 19.1 |
| BMI (kg/m2) | 17.9 +/− 4.7 | 18.8 +/− 2.8 |
| Lifetime joint bleeds | 31.0 +/− 21.6 | 35.2 +/− 27.9 |
| Hemophilia Joint Health Score | 2.6 +/− 3.4 | 4.4 +/− 3.5 |
| Whole body bone mineral content (kg) | 1.2 +/− 0.7 | 1.25 +/− 0.7 |
| Lean body mass (kg) | 26.5 +/− 15.9 | 26.9 +/− 15.2 |
| Fat mass (kg) | 10.2 +/− 6.3 | 25.4 +/− 18.2 |
| Prophylaxis starting age (years, months) | 2.4 +/− 1.8 | 2.7 +/− 2.1 |
| Prophylaxis frequency (days/week) | 2.9 +/− 1.3 | 2.0 +/− 1 |
| Adequate intake calcium (% of subjects) | 75 | 100 |
| Adequate intake vitamin D (% of subjects) | 46 | 40 |
| Adequate intake vitamin K (% of subjects) | 28 | 40 |
| Adequate intake protein (% of subjects) | 91 | 100 |
| Physical Activity Score (out of 10) | 6.6 +/− 1.1 | 6.3 +/− 0.4 |
Univariate analysis hip HAW
| Regimen (vs. 1× week) | 2× week | −0.6333 (−2.2199,0.9532) | 0.4340 |
| Regimen (vs. 1× week) | 3× week | −0.0467 (−1.5201,1.4268) | 0.9505 |
| Joint score > 0 | 1 | −0.3531 (−1.3340,0.6278) | 0.4805 |
| Physical activity: overall | 0.3024 (−0.1655,0.7703) | 0.2052 | |
| Calcium | 1 | 0.7993 (−0.4363,2.0350) | 0.2048 |
| Vitamin D | 1 | 1.0996 (0.1709,2.0282) | 0.0203 |
| Lifetime joint bleeds | 0.0023 (−0.0169,0.0216) | 0.8144 |
Multivariate analysis total body HAW
| Regimen (vs. 1× week) | 2× week | −0.0813 (−1.1006,0.9379) | 0.8757 |
| Regimen (vs. 1× week) | 3× week | 0.3864 (−0.6681,1.4410) | 0.4726 |
| Joint score > 0 | 1 | 0.6312 (0.0632,1.1992) | 0.0294 |
| Physical activity: overall | −0.3563 (−0.8913,0.1786) | 0.1917 | |
| Calcium | 1 | −0.4021 (−1.375,0.5707) | 0.4179 |
| Vitamin D | 1 | 0.6189 (−0.0676,1.3054) | 0.0772 |
| Lifetime joint bleeds | −0.0110 (−0.0261,0.0041) | 0.1528 |
Univariate analysis spine HAW
| Regimen (vs. 1× week) | 2× week | −0.4000 (−1.6579,0.8579) | 0.5331 |
| Regimen (vs. 1× week) | 3× week | −0.1182 (−1.2795,1.0431) | 0.8419 |
| Joint score > 0 | 1 | 0.1095 (−0.6067,0.8257) | 0.7644 |
| Physical activity: overall | 0.1256 (−0.2229,0.4741) | 0.4801 | |
| Calcium | 1 | 0.5588 (−0.3073,1.4249) | 0.2060 |
| Vitamin D | 1 | 0.7800 (0.1023,1.4577) | 0.0241 |
| Lifetime joint bleeds | 0.0095 (−0.0048,0.0238) | 0.1916 |