Open Access

Knowledge Organization and Representation under the AI Lens

   | Apr 22, 2020

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Figure 1

Paradigms in knowledge organization.Source: Qin, 2002
Paradigms in knowledge organization.Source: Qin, 2002

Figure 2

A UMLS example of a concept and relation representation.
A UMLS example of a concept and relation representation.

Major relationships types and patterns between knowledge nodes observed in the sample publications.

RelationshipPatternExample
has-biomarkerDisease has-biomarker Genechronic myeloid leukemia has-biomarker BCR-ABLnon-small cell lung cancer has-biomarker EGFR
is-driver-ofGene is-driver-of DiseaseHer2 is-driver-of breast cancerc-Kit is-driver-of chronic granulocytic leukemia
targetsDrug targets GeneCrizotinib targets ALKOlaparib targets BRCA1/2
has-role-ofDrug has-role-of TreatmentCrizotinib has-role-of oncogene de-addictionOlaparib has-role-of DNA repair

Similarities in goals, methods, and functions between KO and KR paradigms.

ParadigmGoalsMethodsFunctions
KOIntegrationOrganize the knowledge universeCategorize, classify generalize, synthesizeRepresent knowledge in publications and organize knowledge about nature and/or society
DisintegrationOrganize the knowledge in a domainCategorize, classify, generalize, synthesize, modelRepresent knowledge in data and publications in a domain
KRProduction rulesRepresent knowledge in condition-action pairs to solve problemsUse forward chaining algorithms to execute condition-action pairsRepresent fragmentary knowledge in entity-attribute-value (triple) format
Semantic networks and framesRepresent semantic relations between conceptsExpress semantic relations in triplesConnect knowledge nodes through attributes or slots to form a knowledge graph
First-order logicFormalize qualifier construction in natural languageExpress declarative propositions using the first-order logic syntax and semanticsProduce a set of axioms for reasoning

Examples of knowledge nodes derived from the sample publications.

CategoryAtomic level (name of things)Concept levelCluster level
GeneHer2, BRCA1, BRCA2, EGFROncogenesEGFR mutations in lung cancer
DiseaseNon-squamous carcinoma, squamous cell carcinomaNon-small cell lung cancerLung cancer
DrugPertumzumab, Lmatinib, CrizotinibTyrosine kinase inhibitorOncogene de-addiction
eISSN:
2543-683X
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Computer Sciences, Information Technology, Project Management, Databases and Data Mining