An Updated Review of Hypertensive Emergencies and Urgencies

1. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/A A P A / A B C / A C P M / A G S / A P h A / A S H / A S P C / NMA / P C N A Guideline for the Prevention, Detection, Evaluation, and Management of High BP in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71:1269-1324. doi: 10.1161/HYP.0000000000000066.10.1161/HYP.0000000000000066Open DOISearch in Google Scholar

2. Janke AT, McNaughton CD, Brody AM, Welch RD, Levy PD. Trends in the incidence of hypertensive emergencies in US emergency departments from 2006 to 2013. J Am Heart Assoc. 2016;5:e004511. doi:10.1161/JAHA.116.004511.10.1161/JAHA.116.004511Open DOISearch in Google Scholar

3. Vaughan CJ, Delanty N. Hypertensive emergencies. Lancet. 2000;356:411-417.10.1016/S0140-6736(00)02539-3Search in Google Scholar

4. Varounis C, Katsi V, Nihoyannopoulos P, Lekakis J, Tousoulis D. Cardiovascular Hypertensive Crisis: Recent Evidence and Review of the Literature. Frontiers in Cardiovascular Medicine. 2016;3:51. doi:10.3389/fcvm.2016.00051.10.3389/fcvm.2016.00051522278628119918Open DOISearch in Google Scholar

5. Guiga H, Decroux C, Michelet P, et al. Hospital and out-ofhospital mortality in 670 hypertensive emergencies and urgencies. J Clin Hypertens. 2017;19:1137-1142. doi: 10.1111/jch.13083.10.1111/jch.13083803083728866866Open DOISearch in Google Scholar

6. Ipek E, Oktay AA, Krim SR. Hypertensive crisis: an update on clinical approach and management. Curr Opin Cardiol. 2017;32:397-406. doi: 10.1097/HCO.000000000000039.10.1097/HCO.000000000000039Open DOISearch in Google Scholar

7. Lagi A, S Cencetti. Hypertensive emergencies: a new clinical approach. Clinical Hypertension. 2015;21:20. doi.org/10.1186/s40885-015-0027-4.10.1186/s40885-015-0027-4475079526893930Open DOISearch in Google Scholar

8. Marik PE, Varon J. Hypertensive crises: challenges and management. Chest. 2007;131:1949-1962. doi: 10.1378/chest.06-2490.10.1378/chest.06-249017565029Search in Google Scholar

9. Derhaschnig U, Testori C, Riedmueller E, Aschauer S, Wolzt M, Jilma B. Hypertensive emergencies are associated with elevated markers of inflammation, coagulation, platelet activation and fibrinolysis. Journal of Human Hypertension. 2013;27:368-373. doi:10.1038/jhh.2012.53.10.1038/jhh.2012.5323254594Open DOISearch in Google Scholar

10. Taylor DA. Hypertensive crisis: a review of pathophysiology and treatment. Crit Care Nurs Clin North Am. 2015;27:439-447. doi: 10.1016/j.cnc.2015.08.003.10.1016/j.cnc.2015.08.00326567490Search in Google Scholar

11. van den Born BJ, Löwenberg EC, van der Hoeven NV, et al. Endothelial dysfunction, platelet activation, thrombogenesis and fibrinolysis in patients with hypertensive crisis. J Hypertens. 2011;29:922-927. doi:10.1097/HJH.0b013e328345023d.10.1097/HJH.0b013e328345023d21372741Open DOISearch in Google Scholar

12. Gatti R, Santos P, Angela AS, Marangoni K, Araujo M, Goulart L. The interaction of AGT and NOS3 gene polymorphisms with conventional risk factors increases predisposition to hypertension. Journal of Renin-Angiotensin-Aldosterone System. 2012;14:360-368. doi: 10.1177/1470320312452027.10.1177/147032031245202722791701Open DOISearch in Google Scholar

13. Toganel R, Muntean I, Duicu C, Fagarasan A, Gozar L, Banescu C. The role of eNOS and AGT gene polymorphisms in secondary pulmonary arterial hypertension in Romanian children with congenital heart disease. Revista Romana de Medicina de Laborator. 2013;21:267-274. doi: https://doi.org/10.2478/rrlm-2013-0031.10.2478/rrlm-2013-0031Open DOISearch in Google Scholar

14. Varon J, Marik PE. Clinical review: The management of hypertensive crises. Critical Care. 2003;7:374-384. doi: 10.1186/cc2351.10.1186/cc235127071812974970Open DOISearch in Google Scholar

15. Papadopoulos DP, Sanidas EA, Viniou NA, et al. Cardiovascular hypertensive emergencies. Curr Hypertens Rep. 2015;17:5. doi: 10.1007/s11906-014-0515-z.10.1007/s11906-014-0515-z25620633Open DOISearch in Google Scholar

16. Manning L, Robinson TG, Anderson CS. Control of BP in hypertensive neurological emergencies. Curr Hypertens Rep. 2014;16:436. doi: 10.1007/s11906-014-0436-x.10.1007/s11906-014-0436-x24771058Open DOISearch in Google Scholar

17. Keddis MT, Garovic VD. 38-Year-Old Woman with Hypertension, Headaches, and Abdominal Bruit. Mayo Clinic Proceedings. 2010;85:674-677. doi:10.4065/mcp.2009.0330.10.4065/mcp.2009.0330289472320592173Open DOISearch in Google Scholar

18. Elliott WJ. Clinical features and management of selected hypertensive emergencies. J Clin Hypertens (Greenwich). 2004;6:587-592.10.1111/j.1524-6175.2004.03608.x810933115470289Search in Google Scholar

19. Pergolini MS. The management of hypertensive crises: a clinical review. Clin Ter. 2009;160:151-157.Search in Google Scholar

20. Varon J. The diagnosis and treatment of hypertensive crises. Postgrad Med. 2009;121:5-13. doi:10.3810/pgm.2009.01.1950.10.3810/pgm.2009.01.195019179809Open DOISearch in Google Scholar

21. Aronow WS. Treatment of hypertensive emergencies. Ann Transl Med. 2017;5:S5. doi: 10.21037/atm.2017.03.34.10.21037/atm.2017.03.34544031028567387Search in Google Scholar

22. Polly DM, Paciullo CA, Hatfield CJ. Management of hypertensive emergency and urgency. Adv Emerg Nurs J. 2011;33:127-136. doi: 10.1097/TME.0b013e318217a564.10.1097/TME.0b013e318217a56421543908Open DOISearch in Google Scholar

23. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013;31:1281-1357. doi: 10.1097/01.hjh.0000431740.32696.cc.10.1097/01.hjh.0000431740.32696.cc23817082Open DOISearch in Google Scholar

24. Grassi D, O’Flaherty M, Pellizzari M, et al. Hypertensive urgencies in the emergency department: evaluating blood pressure response to rest and to antihypertensive drugs with different profiles. J Clin Hypertens (Greenwich). 2008;10:662-667. doi: 10.1111/j.1751-7176.2008.00001.x.10.1111/j.1751-7176.2008.00001.x867333718844760Search in Google Scholar

25. Perez MI, Musini VM. Pharmacological interventions for hypertensive emergencies: a Cochrane systematic review. J Hum Hypertens. 2008;22:596-607. doi: 10.1038/jhh.2008.25.10.1038/jhh.2008.2518418399Open DOISearch in Google Scholar

26. Mansoor GA, Frishman WH. Comprehensive management of hypertensive emergencies and urgencies. Heart Dis. 2002;4:358-371. doi: 10.1097/01.HDX.0000038720.26409.41.10.1097/01.HDX.0000038720.26409.41Open DOISearch in Google Scholar

27. Fenves AZ, Ram CV. Drug treatment of hypertensive urgencies and emergencies. Semin Nephrol. 2005;25:272-280. doi: 10.1016/j.semnephrol.2005.02.011.10.1016/j.semnephrol.2005.02.01116202700Open DOISearch in Google Scholar

28. Rhoney D, Peacock WF. Intravenous therapy for hypertensive emergencies, part 1. Am J Health Syst Pharm. 2009; 66:1343-1352. Am J Health Syst Pharm. 20091;66:1343-1352. doi: 10.2146/ajhp080348.p1.10.2146/ajhp080348.p119635770Open DOISearch in Google Scholar

29. Landoni G, Turi S, Biondi-Zoccai G, et al. Esmolol reduces perioperative ischemia in noncardiac surgery: a meta-analysis of randomized controlled studies. J Cardiothorac Vasc Anesth. 2010;24:219-229. doi: 10.1053/j.jvca.2009.07.008.10.1053/j.jvca.2009.07.00819800816Open DOISearch in Google Scholar

30. Ozawa Y, Hayashi K, Kobori H. New Generation Calcium Channel Blockers in Hypertensive Treatment. Current hypertension reviews. 2006;2:103-111. doi: 10.2174/157340206776877370.10.2174/157340206776877370275976419823601Open DOISearch in Google Scholar

31. Peacock WF, Varon J, Baumann BM, et al. CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department. Crit Care. 2011;15:R157. doi: 10.1186/cc10289.10.1186/cc10289321903121707983Open DOISearch in Google Scholar

32. Komura SN, Awad NI. The utility of bolus intravenous nicardipine for hypertensive emergencies in the ED. The American Journal of Emergency Medicine. 2016;34:2250.e1-2250.e3. doi:10.1016/j.ajem.2016.03.050.10.1016/j.ajem.2016.03.05027079503Open DOISearch in Google Scholar

33. Bergese SD, Puente EG. Clevidipine butyrate: a promising new drug for the management of acute hypertension. Expert Opin Pharmacother. 2010;11:281-295. doi: 10.1517/14656560903499293.10.1517/1465656090349929320088748Open DOISearch in Google Scholar

34. Nguyen HM, Ma K, Pham DQ. Clevidipine for the treatment of severe hypertension in adults. Clin Ther. 2010;32:11-23. doi: 10.1016/j.clinthera.2010.01.025.10.1016/j.clinthera.2010.01.02520171407Open DOISearch in Google Scholar

35. Aronson S, Dyke CM, Stierer KA, et al. The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients. Anesth Analg. 2008;107:1110-1121. doi: 10.1213/ane.0b013e31818240db.10.1213/ane.0b013e31818240db18806012Open DOISearch in Google Scholar

36. Hottinger DG, Beebe DS, Kozhimannil T, Prielipp RC, Belani KG. Sodium nitroprusside in 2014: A clinical concepts review. Journal of Anaesthesiology, Clinical Pharmacology. 2014;30:462-471. doi: 10.4103/0970-9185.142799.10.4103/0970-9185.142799423477925425768Open DOISearch in Google Scholar

37. Immink RV, van den Born BJ, van Montfrans GA, et al. Cerebral hemodynamics during treatment with sodium nitroprusside versus labetalol in malignant hypertension. Hypertension. 2008;52:236-240. doi: 10.4103/0970-9185.142799.10.4103/0970-9185.142799Open DOISearch in Google Scholar

38. Muiesan ML, Salvetti M, Amadoro V, et al. An update on hypertensive emergencies and urgencies. J Cardiovasc Med (Hagerstown). 2015;16:372-382. doi: 10.2459/JCM.0000000000000223.10.2459/JCM.000000000000022325575271Open DOISearch in Google Scholar

39. Sharma C, Soni A, Gupta A, Verma A, Verma S. Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial. Am J Obstet Gynecol. 2017;217:687. e1-687.e6. doi: 10.1016/j.ajog.2017.08.018.10.1016/j.ajog.2017.08.01828867601Open DOISearch in Google Scholar

40. Gillies MA, Kakar V, Parker RJ, et al. Fenoldopam to prevent acute kidney injury after major surgery-a systematic review and meta-analysis. Crit Care. 2015;19:449. doi:10.1186/s13054-015-1166-4.10.1186/s13054-015-1166-4469934326703329Open DOISearch in Google Scholar

41. Ayaz SI, Sharkey CM, Kwiatkowski GM, et al. Intravenous enalaprilat for treatment of acute hypertensive heart failure in the emergency department. International Journal of Emergency Medicine. 2016;9:28. doi: 10.1186/s12245-016-0125-4.10.1186/s12245-016-0125-4519592228032307Open DOISearch in Google Scholar

42. Tulman DB, Stawicki SPA, Papadimos TJ, Murphy CV, Bergese SD. Advances in Management of Acute Hypertension: A Concise Review. Discovery medicine. 2012;13:375-383.Search in Google Scholar

43. Gupta PK, Gupta H, Khoynezhad A. Hypertensive Emergency in Aortic Dissection and Thoracic Aortic Aneurysm – A Review of Management. Pharmaceuticals. 2009;2:66-76. doi: 10.3390/ph2030066.10.3390/ph2030066397853227713224Open DOISearch in Google Scholar

44. Peacock WF, Chandra A, Char D, et al. Clevidipine in acute heart failure: Results of the A Study of BP Control in Acute Heart Failure-A Pilot Study (PRONTO). Am Heart J. 2014;167:529-536. doi: 10.1016/j.ahj.2013.12.023.10.1016/j.ahj.2013.12.02324655702Open DOISearch in Google Scholar

45. Kühl M, Lip GY, Varma C. Management of hypertension in relation to acute coronary syndromes and revascularisation. Curr Pharm Des. 2007;13:2556-2566.10.2174/13816120778166304617897000Search in Google Scholar

46. Diercks DB, Ohman EM. Hypertension with acute coronary syndrome and heart failure. Ann Emerg Med. 2008;51:S34-36. doi: 10.1016/j.annemergmed.2007.11.012.10.1016/j.annemergmed.2007.11.01218191288Open DOISearch in Google Scholar

47. Peacock WF, Varon J, Ebrahimi R, Dunbar L, Pollack CV. Clevidipine for severe hypertension in patients with renal dysfunction: A VELOCITY trial analysis. Blood Press Suppl. 2011;1:20-25. doi: 10.3109/08037051.2010.539317.10.3109/08037051.2010.539317303858721091269Open DOISearch in Google Scholar

48. Varon J, Soto-Ruiz KM, Baumann BM, et al. The management of acute hypertension in patients with renal dysfunction: labetalol or nicardipine? Postgrad Med. 2014;126:124-130. doi: 10.3810/pgm.2014.07.2790.10.3810/pgm.2014.07.279025141250Open DOISearch in Google Scholar

49. Olson-Chen C, Seligman NS. Hypertensive emergencies in pregnancy. Crit Care Clin. 2016;32:29-41. doi: 10.1016/j.ccc.2015.08.006.10.1016/j.ccc.2015.08.00626600442Open DOISearch in Google Scholar

50. Ahuja K, Charap MH. Management of perioperative hypertensive urgencies with parenteral medications. J Hosp Med. 2010;5:E11-16. doi: 10.1002/jhm.629.10.1002/jhm.62920104635Open DOISearch in Google Scholar

51. Espinosa A, Ripollés–Melchor J, Casans-Francés R, et al. Perioperative Use of Clevidipine: A Systematic Review and Meta-Analysis. PLoS ONE. 2016;11:e0150625. doi: 10.1371/journal.pone.0150625.10.1371/journal.pone.0150625480956727018586Search in Google Scholar

52. Kurnutala LN, Soghomonyan S, Bergese SD. Perioperative acute hypertension – role of Clevidipine butyrate. Frontiers in Pharmacology. 2014;5:197. doi: 10.3389/fphar.2014.00197.10.3389/fphar.2014.00197414534825221513Open DOISearch in Google Scholar

53. Lenders JWM, Duh QY, Eisenhofer G, et al. Pheochromocytoma and Paraganglioma: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2014;99:1915-1942. doi:10.1210/jc.2014-1498.10.1210/jc.2014-1498Open DOISearch in Google Scholar

54. Suzuki T, Eagle KA, Bossone E, Ballotta A, Froehlich JB, Isselbacher EM. Medical management in type B aortic dissection. Annals of Cardiothoracic Surgery. 2014;3:413-417. doi:10.3978/j.issn.2225-319X.2014.07.01.10.3978/j.issn.2225-319X.2014.07.01Open DOISearch in Google Scholar

55. Anderson CS, Huang Y, Wang JG, et al. Intensive BP reduction in acute cerebral haemorrhage trial (INTERACT): a randomized pilot trial. Lancet Neurol. 2008;7:391-399. doi: 10.1016/S1474-4422(08)70069-3.10.1016/S1474-4422(08)70069-3Open DOISearch in Google Scholar

56. Jauch EC, Saver JL, Adams HP Jr, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44:870-947. doi: 10.1161/STR.0b013e318284056a.10.1161/STR.0b013e318284056a23370205Open DOISearch in Google Scholar

57. Butcher KS, Jeerakathil T, Hill M, et al. The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial. Stroke. 2013;44:620-626. doi: 10.1161/STROKEAHA.111.000188.10.1161/STROKEAHA.111.00018823391776Open DOISearch in Google Scholar

58. Ahmed N, Wahlgren N, Brainin M, et al. Relationship of BP, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR). Stroke. 2009;40:2442-2449. doi: 10.1161/STROKEAHA.109.548602.10.1161/STROKEAHA.109.54860219461022Open DOISearch in Google Scholar

59. He J, Zhang Y, Xu T, et al. Effects of immediate BP reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial. JAMA. 2014;311:479-489. doi: 10.1001/jama.2013.282543.10.1001/jama.2013.28254324240777Open DOISearch in Google Scholar