<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jccm-2019-0019_s_006_w2aab3b7b1b1b6b1aab1c18b1Aa"><h3>Introduction</h3><p>Sepsis is a life-threatening condition, and sepsis-associated thrombocytopenia (SAT) is a common consequence of the disease where platelet count falls drastically within a very short time. Multiple key factors may cause platelet over-activation, destruction and reduction in platelet production during the sepsis. Eltrombopag is a thrombopoietin receptor agonist and is the second-line drug of choice in the treatment of chronic immune thrombocytopenia (ITP).</p></sec><sec id="j_jccm-2019-0019_s_007_w2aab3b7b1b1b6b1aab1c18b2Aa"><h3>Aim of the study</h3><p>The objective of this study was to observe the therapeutic outcome of high dose eltrombopag in SAT management in critically ill patients.</p></sec><sec id="j_jccm-2019-0019_s_008_w2aab3b7b1b1b6b1aab1c18b3Aa"><h3>Material and Methods</h3><p>This 6-month-long single group, observational study was conducted on seventeen ICU patients with SAT. Eltrombopag 100 mg/day in two divided doses was given to each patient. Platelet counts were monitored. A low platelet blood count returning to 150 K/μL or above, is taken as indicative of a successful reversal of a thrombocytopenia event.</p></sec><sec id="j_jccm-2019-0019_s_009_w2aab3b7b1b1b6b1aab1c18b4Aa"><h3>Results</h3><p>The mean Apache II score of patients (n= 17) was 18.71 (p-value: >0.05). No eltrombopag-induced adverse event was observed among the patients during the study period. Thrombocytopenia events were reversed successfully in 64.71% of patients (11; n= 17) within eight days of eltrombopag therapy.</p></sec><sec id="j_jccm-2019-0019_s_010_w2aab3b7b1b1b6b1aab1c18b5Aa"><h3>Conclusions</h3><p>The therapeutic potentiality of high dose eltrombopag regime in the management of sepsis-associated thrombocytopenia was found clinically significant in over two-thirds of critically ill adult patients enrolled in the study. These data may point to a new strategy in the management of acute type of thrombocytopenia in septic patients.</p></sec></abstract>

IntroductionSepsis is a life-threatening condition, and sepsis-associated thrombocytopenia (SAT) is a common consequence of the disease where platelet count falls drastically within a very short time. Multiple key factors may cause platelet over-activation, destruction and reduction in platelet production during the sepsis. Eltrombopag is a thrombopoietin receptor agonist and is the second-line drug of choice in the treatment of chronic immune thrombocytopenia (ITP).Aim of the studyThe objective of this study was to observe the therapeutic outcome of high dose eltrombopag in SAT management in critically ill patients.Material and MethodsThis 6-month-long single group, observational study was conducted on seventeen ICU patients with SAT. Eltrombopag 100 mg/day in two divided doses was given to each patient. Platelet counts were monitored. A low platelet blood count returning to 150 K/μL or above, is taken as indicative of a successful reversal of a thrombocytopenia event.ResultsThe mean Apache II score of patients (n= 17) was 18.71 (p-value: >0.05). No eltrombopag-induced adverse event was observed among the patients during the study period. Thrombocytopenia events were reversed successfully in 64.71% of patients (11; n= 17) within eight days of eltrombopag therapy.ConclusionsThe therapeutic potentiality of high dose eltrombopag regime in the management of sepsis-associated thrombocytopenia was found clinically significant in over two-thirds of critically ill adult patients enrolled in the study. These data may point to a new strategy in the management of acute type of thrombocytopenia in septic patients.

The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

IntroductionSepsis is a life-threatening condition, and sepsis-associated thrombocytopenia (SAT) is a common consequence of the disease where platelet count...

The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients

Article Category: Research Article

Published Online: Nov 27, 2019

Page range: 123 - 129

Received: May 15, 2019

Accepted: Aug 05, 2019

DOI: https://doi.org/10.2478/jccm-2019-0019

Keywords
Eltrombopag, sepsis, thrombocytopenia, megakaryocytes, thrombopoietin receptor

© 2019 Md. Jahidul Hasan, Raihan Rabbani, Shihan Mahmud Redwanul Huq, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients

Article Category: Research Article

Published Online: Nov 27, 2019

Page range: 123 - 129

Received: May 15, 2019

Accepted: Aug 05, 2019

DOI: https://doi.org/10.2478/jccm-2019-0019

KeywordsEltrombopag, sepsis, thrombocytopenia, megakaryocytes, thrombopoietin receptor

© 2019 Md. Jahidul Hasan, Raihan Rabbani, Shihan Mahmud Redwanul Huq, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Eltrombopag, sepsis, thrombocytopenia, megakaryocytes, thrombopoietin receptor