<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction</bold>: Upper gastrointestinal bleeding is an uncommon but possible life-threatening entity in children, frequently caused by erosive gastritis. Non-steroidal anti-inflammatory drugs are one of the most common class of drugs which can cause gastrointestinal complications, including hemorrhagic gastritis.<bold>Case report</bold>: The case of a 6-year-old male, admitted for hematemesis, abdominal pain and loss of appetite. It was ascertained at the time of admission, that ibuprofen had been prescribed as the patient had a fever. This was inappropriately administered as the mother did not respect the intervals between the doses.Initial laboratory tests revealed neutrophilia, leukopenia, high levels of lactate dehydrogenase and urea. An upper digestive endoscopy revealed an increased friability of the mucosa, digested blood in the gastric corpus and fornix. No active bleeding site was detected. The histopathological examination described a reactive modification of the corporeal gastric mucosa. Intravenous treatment with proton pump inhibitors and fluid replacement were initiated, with favorable results.<bold>Conclusion</bold>: Ibuprofen can lead to upper digestive hemorrhage independently of the administered dose. Parents should avoid administering Ibuprofen for fever suppression without consulting their pediatrician.</abstract>

Introduction: Upper gastrointestinal bleeding is an uncommon but possible life-threatening entity in children, frequently caused by erosive gastritis. Non-steroidal anti-inflammatory drugs are one of the most common class of drugs which can cause gastrointestinal complications, including hemorrhagic gastritis.Case report: The case of a 6-year-old male, admitted for hematemesis, abdominal pain and loss of appetite. It was ascertained at the time of admission, that ibuprofen had been prescribed as the patient had a fever. This was inappropriately administered as the mother did not respect the intervals between the doses.Initial laboratory tests revealed neutrophilia, leukopenia, high levels of lactate dehydrogenase and urea. An upper digestive endoscopy revealed an increased friability of the mucosa, digested blood in the gastric corpus and fornix. No active bleeding site was detected. The histopathological examination described a reactive modification of the corporeal gastric mucosa. Intravenous treatment with proton pump inhibitors and fluid replacement were initiated, with favorable results.Conclusion: Ibuprofen can lead to upper digestive hemorrhage independently of the administered dose. Parents should avoid administering Ibuprofen for fever suppression without consulting their pediatrician.

Ibuprofen, a Potential Cause of Acute Hemorrhagic Gastritis in Children - A Case Report

Pathology Department County Clinic Hospital

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Introduction: Upper gastrointestinal bleeding is an uncommon but possible life-threatening entity in children, frequently caused by erosive gastritis....

Ibuprofen, a Potential Cause of Acute Hemorrhagic Gastritis in Children - A Case Report

Published Online: Nov 14, 2018

Page range: 143 - 146

Received: Apr 16, 2018

Accepted: Oct 03, 2018

DOI: https://doi.org/10.2478/jccm-2018-0022

Keywords
upper gastrointestinal bleeding, hemorrhagic gastritis, ibuprofen

© 2018 Maria Oana Mărginean et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Ibuprofen, a Potential Cause of Acute Hemorrhagic Gastritis in Children - A Case Report

Published Online: Nov 14, 2018

Page range: 143 - 146

Received: Apr 16, 2018

Accepted: Oct 03, 2018

DOI: https://doi.org/10.2478/jccm-2018-0022

Keywordsupper gastrointestinal bleeding, hemorrhagic gastritis, ibuprofen

© 2018 Maria Oana Mărginean et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
upper gastrointestinal bleeding, hemorrhagic gastritis, ibuprofen