<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background</bold>: <italic>Elizabethkingia meningoseptica</italic> are Gram-negative rod bacteria which are commonly found in the environment. The bacteria have also been associated with nosocomial infections, having been isolated on contaminated medical equipment, especially in neonatal wards.<bold>Case report</bold>: Here, we present the case of a premature female infant born at 33 weeks’ gestational age, with neonatal meningitis. The onset was marked by fever, in the 5th day of life, while in the Neonatal Intensive Care Unit. The patient was commenced on Gentamicin and Ampicillin, but her clinical condition worsened. Psychomotor agitation and food refusal developed in the 10th day of life, and a diagnosis of bacterial meningitis was made based on clinical and cerebrospinal fluid findings. A strain of <italic>Elizabethkingia meningoseptica</italic> sensitive to Vancomycin, Rifampicin and Clarithromycin was isolated from cerebrospinal fluid. First-line antibiotic therapy with Meropenem and Vancomycin was adjusted by replacing Meronem with Piperacillin/Tazobactam and Rifampicin. The patient’s clinical condition improved, although some isolated febrile episodes were still present. The cerebrospinal fluid was normalized after 6 weeks of antibiotic treatment, although periventriculitis and tetraventricular hydrocephalus were revealed by imaging studies. Neurosurgical drainage was necessary.<bold>Conclusion</bold>: <italic>Elizabethkingia meningoseptica</italic> can cause severe infection, with high risk of mortality and neurological sequelae in neonates. Intensive care and multidisciplinary interventions are crucial for case management.</abstract>

Background: Elizabethkingia meningoseptica are Gram-negative rod bacteria which are commonly found in the environment. The bacteria have also been associated with nosocomial infections, having been isolated on contaminated medical equipment, especially in neonatal wards.Case report: Here, we present the case of a premature female infant born at 33 weeks’ gestational age, with neonatal meningitis. The onset was marked by fever, in the 5th day of life, while in the Neonatal Intensive Care Unit. The patient was commenced on Gentamicin and Ampicillin, but her clinical condition worsened. Psychomotor agitation and food refusal developed in the 10th day of life, and a diagnosis of bacterial meningitis was made based on clinical and cerebrospinal fluid findings. A strain of Elizabethkingia meningoseptica sensitive to Vancomycin, Rifampicin and Clarithromycin was isolated from cerebrospinal fluid. First-line antibiotic therapy with Meropenem and Vancomycin was adjusted by replacing Meronem with Piperacillin/Tazobactam and Rifampicin. The patient’s clinical condition improved, although some isolated febrile episodes were still present. The cerebrospinal fluid was normalized after 6 weeks of antibiotic treatment, although periventriculitis and tetraventricular hydrocephalus were revealed by imaging studies. Neurosurgical drainage was necessary.Conclusion: Elizabethkingia meningoseptica can cause severe infection, with high risk of mortality and neurological sequelae in neonates. Intensive care and multidisciplinary interventions are crucial for case management.

Emerging Infection with <italic>Elizabethkingia meningoseptica</italic> in Neonate. A Case Report

Infectious Diseases Clinical Hospital Galati

Emergency Pediatric Clinical Hospital Galati

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Emerging Infection with  in Neonate. A Case Report

Background: Elizabethkingia meningoseptica are Gram-negative rod bacteria which are commonly found in the environment. The bacteria have also been associated...

Emerging Infection with Elizabethkingia meningoseptica in Neonate. A Case Report

Published Online: Aug 09, 2018

Page range: 96 - 100

Received: Mar 03, 2018

Accepted: May 04, 2018

DOI: https://doi.org/10.2478/jccm-2018-0013

Keywords
neonatal meningitis, emergent infection, nosocomial

© 2018 Manuela Arbune et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Emerging Infection with Elizabethkingia meningoseptica in Neonate. A Case Report

Published Online: Aug 09, 2018

Page range: 96 - 100

Received: Mar 03, 2018

Accepted: May 04, 2018

DOI: https://doi.org/10.2478/jccm-2018-0013

Keywordsneonatal meningitis, emergent infection, nosocomial

© 2018 Manuela Arbune et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
neonatal meningitis, emergent infection, nosocomial