<abstract xmlns="http://www.w3.org/1999/xhtml">Squamous cell carcinoma is the cause in most cases of cervical cancer. A very unusual subtype of squamous cell carcinoma is lymphoepithelioma-like carcinoma, found in less than 1% of the neoplasm processes in the uterine cervix. Histologically it looks like a large nest of big-sized tumor cells with large vascular nuclei. Immunohistochemical markers used for LELC are p63, p16, human leukocyte antigen-D related (HLA-DR), and B-cell lymphoma 2. Even though it has aggressive morphological features, it has a better prognosis than most carcinoma cases of the uterine cervix. The condition is treatable, with a hysterectomy and bilateral salpingo-oophorectomy as the most common method. There are rare cases of pelvic lymph node dissection reported in the literature.There is data that lymphoepithelioma-like carcinoma is associated with the Ebstein-Barr virus and human papillomavirus. According to a survey by Tseng et al. and Chao et al., EBV is associated with LELC in Asian women, while HPV is associated with Caucasian women.Due to the small number of studies found in the literature, no conclusion can be drawn concerning the said viruses’ involvement in Asian and Caucasian patients.</abstract>

Squamous cell carcinoma is the cause in most cases of cervical cancer. A very unusual subtype of squamous cell carcinoma is lymphoepithelioma-like carcinoma, found in less than 1% of the neoplasm processes in the uterine cervix. Histologically it looks like a large nest of big-sized tumor cells with large vascular nuclei. Immunohistochemical markers used for LELC are p63, p16, human leukocyte antigen-D related (HLA-DR), and B-cell lymphoma 2. Even though it has aggressive morphological features, it has a better prognosis than most carcinoma cases of the uterine cervix. The condition is treatable, with a hysterectomy and bilateral salpingo-oophorectomy as the most common method. There are rare cases of pelvic lymph node dissection reported in the literature.There is data that lymphoepithelioma-like carcinoma is associated with the Ebstein-Barr virus and human papillomavirus. According to a survey by Tseng et al. and Chao et al., EBV is associated with LELC in Asian women, while HPV is associated with Caucasian women.Due to the small number of studies found in the literature, no conclusion can be drawn concerning the said viruses’ involvement in Asian and Caucasian patients.

Presence of EBV and HPV Infection in Lymphoepithelioma-Like Carcinoma in the Uterine Cervix

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Squamous cell carcinoma is the cause in most cases of cervical cancer. A very unusual subtype of squamous cell carcinoma is lymphoepithelioma-like carcinoma,...

Presence of EBV and HPV Infection in Lymphoepithelioma-Like Carcinoma in the Uterine Cervix

Published Online: Jan 21, 2021

Page range: 110 - 115

Received: Sep 14, 2020

Accepted: Dec 11, 2020

DOI: https://doi.org/10.2478/jbcr-2020-0015

Keywords
Ebstein-Barr virus, human papillomavirus, lymphoepithelioma-like carcinoma

© 2020 Diana S. Strateva et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Presence of EBV and HPV Infection in Lymphoepithelioma-Like Carcinoma in the Uterine Cervix

Published Online: Jan 21, 2021

Page range: 110 - 115

Received: Sep 14, 2020

Accepted: Dec 11, 2020

DOI: https://doi.org/10.2478/jbcr-2020-0015

KeywordsEbstein-Barr virus, human papillomavirus, lymphoepithelioma-like carcinoma

© 2020 Diana S. Strateva et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Ebstein-Barr virus, human papillomavirus, lymphoepithelioma-like carcinoma