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Medicinal plants and natural products can play a significant role in mitigation of mercury toxicity


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Abarikwu SO, Benjamin S, Ebah SG, Obilor G, Agbam G. (2017). Oral administration of Moringa oleifera oil but not coconut oil prevents mercury-induced testicular toxicity in rats. Andrologia49: e12597.Search in Google Scholar

Abd El-Aziz GS, El-Fark MM, Saleh HA. (2012). The prenatal toxic effect of methylmercury on the development of the appendicular skeleton of rat fetuses and the protective role of vitamin E. Anat Rec (Hoboken)295: 939–949.Search in Google Scholar

Abdalla FH, Bellé LP, De Bona KS, Bitencourt PE, Pigatto AS, Moretto MB. (2010). Allium sativum L. extract prevents methyl mercury-induced cytotoxicity in peripheral blood leukocytes (LS). Food Chem Toxicol48: 417–421.Search in Google Scholar

Aflanie I. (2015). Effect of heavy metal on malondialdehyde and advanced oxidation protein products concentration: A focus on arsenic, cadmium, and mercury. J Med Bioengg4: 332–337.Search in Google Scholar

Agarwal R, Goel SK, Behari JR. (2010b). Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. J Appl Toxicol30: 457–68.10.1002/jat.151720229497Search in Google Scholar

Agarwal R, Goel SK, Chandra R, Behari JR. (2010a). Role of vitamin E in preventing acute mercury toxicity in rat. Environ Toxicol Pharmacol29: 70–78.10.1016/j.etap.2009.10.00321787585Search in Google Scholar

Ahn CB, Song CH, Kim WH, Kim YK. (2002). Effects of Juglans sinensis Dode extract and antioxidant on mercury chloride-induced acute renal failure in rabbits. J Ethnopharmacol82: 45–49.Search in Google Scholar

Alam MS, Kaur G, Jabbar Z, Javed K, Athar M. (2007). Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity. Food Chem Toxicol45: 910–20.Search in Google Scholar

Andersen HR, Andersen O. (1993). Effects of dietary alpha-tocopherol and beta-carotene on lipid peroxidation induced by methyl mercuric chloride in mice. Pharmacol Toxicol73: 192–201.Search in Google Scholar

Ansar S. (2015). Pretreatment with diallylsulphide modulates mercury-induced neurotoxicity in male rats. Acta Biochimica Polonica62: 599–603.Search in Google Scholar

Arantes LP, Peres TV, Chen P, Caito S, Aschner M, Soares FA. (2016). Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans. Toxicol Res (Camb)5: 1629–1638.Search in Google Scholar

Asadi S, Zhang B, Weng Z, Angelidou A, Kempuraj D, Alysandratos KD, Theoharides TC. (2010). Luteolin and thiosalicylate inhibit HgCl(2) and thimerosal-induced VEGF release from human mast cells. Int J Immunopathol Pharmacol23: 1015–1020.Search in Google Scholar

Augusti PR, Conterato GM, Somacal S, Einsfeld L, Ramos AT, Hosomi FY, Graça DL, Emanuelli T. (2007). Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol100: 398–402.Search in Google Scholar

Augusti PR, Conterato GM, Somacal S, Sobieski R, Spohr PR, Torres JV, Charão MF, Moro AM, Rocha MP, Garcia SC, Emanuelli T. (2008). Effect of astaxan-thin on kidney function impairment and oxidative stress induced by mercuric chloride in rats. Food Chem Toxicol46: 212–219.Search in Google Scholar

Ayyathan DM, Chandrasekaran R, Thiagarajan K. (2015). Neuroprotective effect of Brahmi, an ayurvedic drug against oxidative stress induced by methyl mercury toxicity in rat brain mitochondrial-enriched fractions. Nat Prod Res29: 1046–1051.Search in Google Scholar

Babu K, Uma Maheswari KC. (2006). In vivo studies on the effect of Ocimum sanctum L. leaf extract in modifying the genotoxicity induced by chromium and mercury in Allium root meristems. J Environ Biol27: 93–95.Search in Google Scholar

Barcelos GR, Angeli JP, Serpeloni JM, Grotto D, Rocha BA, Bastos JK, Knasmüller S, Júnior FB. (2011b). Quercetin protects human-derived liver cells against mercury-induced DNA-damage and alterations of the redox status. Mutat Res726: 109–115.10.1016/j.mrgentox.2011.05.01121820078Search in Google Scholar

Barcelos GR, Grotto D, Serpeloni JM, Aissa AF, Antunes LM, Knasmüller S, Barbosa F Jr. (2012). Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. Environ Mol Mutagen53: 535–541.Search in Google Scholar

Barcelos GR, Grotto D, Serpeloni JM, Angeli JP, Rocha BA, de Oliveira Souza VC, Vicentini JT, Emanuelli T, Bastos JK, Antunes LM, Knasmüller S, Barbosa F Jr. (2011a). Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats. Arch Toxicol85: 1151–1157.10.1007/s00204-011-0652-y21286687Search in Google Scholar

Bellé LP, De Bona KS, Abdalla FH, Pimentel VC, Pigatto AS, Moretto MB. (2009). Comparative evaluation of adenosine deaminase activity in cerebral cortex and hippocampus of young and adult rats: effect of garlic extract (Allium sativum L.) on their susceptibility to heavy metal exposure. Basic Clin Pharmacol Toxicol104: 408–413.Search in Google Scholar

Bernhoft RA. (2012). Mercury toxicity and treatment: a review of the literature. J Environ Public Health2012: Article ID 460508.Search in Google Scholar

Bhattacharya S, Haldar PK. (2011). Trichosanthes dioica root extract induces tumor proliferation and attenuation of antioxidant system in albino mice bearing Ehrlich ascites carcinoma. Interdiscip Toxicol4: 184–90.Search in Google Scholar

Bhattacharya S, Haldar PK. (2012a). Trichosanthes dioica root possesses stimulant laxative activity in mice. Nat Prod Res26: 952–957.10.1080/14786419.2010.53516121827370Search in Google Scholar

Bhattacharya S, Haldar PK. (2012b). Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents. Nat Prod Res26: 2348–2352.10.1080/14786419.2012.65611122288562Search in Google Scholar

Bhattacharya S. (2017). Medicinal plants and natural products in amelioration of arsenic toxicity: a short review. Pharm Biol55: 349–354.Search in Google Scholar

Bhattacharya S. (2018). The role of medicinal plants and natural products in melioration of cadmium toxicity. Oriental Pharm Exp Med 18 (3): pp 177–18610.1007/s13596-018-0323-0Search in Google Scholar

Boroushaki MT, Mollazadeh H, Rajabian A, Dolati K, Hoseini A, Paseban M, Farzadnia M. (2014). Protective effect of pomegranate seed oil against mercuric chloride-induced nephrotoxicity in rat. Ren Fail36: 1581–1586.Search in Google Scholar

Cavusoglu K, Oruc E, Yapar K, Yalcin E. (2009). Protective effect of lycopene against mercury-induced cytotoxicity in albino mice: pathological evaluation. J Environ Biol 30: 807–814.Search in Google Scholar

Cunha FAB, Pinho AI, Santos JFS, Sobral-Souza CE, Leite NF, Albuquerque RS, Tintino SR, Costa JGM, Matias EFF, Boligon AA, Waczuk EP, Rocha JBT, Posser T, Coutinho HDM, Quintans-Junior LJ, Franco JL. (2016). Cytoprotective effect of Eugenia uniflora L. against the waste contaminant mercury chlo-ride. Arabian J Chemhttp://dx.doi.org/10.1016/j.arabjc.2016.04.018.10.1016/j.arabjc.2016.04.018Open DOISearch in Google Scholar

Das SK, Bhattacharya S, Kundu A. (2013). Rationalized design, synthesis and pharmacological screening of amino acid linked spiro pyrrolidino oxyin-dole analogs through environment friendly reaction. J Adv Pharm Technol Res4: 198–205.Search in Google Scholar

Deng Y, Xu Z, Liu W, Yang H, Xu B, Wei Y. (2012). Effects of lycopene and proanthocyanidins on hepatotoxicity induced by mercuric chloride in rats. Biol Trace Elem Res146: 213–223.Search in Google Scholar

Elseady Y, Zahran E. (2013). Ameliorating effect of β-carotene on antioxidant response and hematological parameters of mercuric chloride toxicity in Nile tilapia (Oreochromis niloticus). Fish Physiol Biochem39: 1031–1041.Search in Google Scholar

Figueredo FG, Lima LF, Morais-Braga MF, Tintino SR, Farias PA, Matias EF, Costa JG, Menezes IR, Pereira RL, Coutinho HD. (2016). Cytoprotective effect of Lygodium venustum Sw. (Lygodiaceae) against mercurium chloride toxicity. Scientifica (Cairo) 2016: 4154265.Search in Google Scholar

Franco JL, Posser T, Missau F, Pizzolatti MG, Dos Santos AR, Souza DO, Aschner M, Rocha JB, Dafre AL, Farina M. (2010). Structure-activity relationship of flavonoids derived from medicinal plants in preventing methylmercury-induced mitochondrial dysfunction. Environ Toxicol Pharmacol30: 272–278.Search in Google Scholar

Frenedoso da Silva R, Missassi G, dos Santos Borges C, Silva de Paula E, Hornos Carneiro MF, Grotto D, Barbosa Junior F, De Grava Kempinas W. (2014). Phytoremediation potential of Maná-Cubiu (Solanum sessiliflorum Dunal) for the deleterious effects of methylmercury on the reproductive system of rats. Biomed Res Int2014: 309631.Search in Google Scholar

Gado AM, Aldahmash BA. (2013). Antioxidant effect of Arabic gum against mercuric chloride-induced nephrotoxicity. Drug Des Devel Ther7: 1245–1452.Search in Google Scholar

Gao D, Zeng LN, Zhang P, Ma ZJ, Li RS, Zhao YL, Zhang YM, Guo YM, Niu M, Bai ZF, Xiao XH, Gao WW, Wang JB. (2016). Rhubarb anthraquinones protect rats against mercuric chloride (HgCl2)-induced acute renal failure. Molecules21: 298.Search in Google Scholar

García-Niño WR, Pedraza-Chaverrí J. (2014). Protective effect of curcumin against heavy metals-induced liver damage. Food Chem Toxicol69: 182-201.Search in Google Scholar

Gupta VK, Siddiqi NJ, Singh S, Agrawal A, Sharma B. (2015). Phytochemicals mediated remediation of neurotoxicity induced by heavy metals. Biochem Res Int2015 Article ID 534769.10.1155/2015/534769465167226618004Search in Google Scholar

Hallal N, Kharoubi O, Benyettou I, Tair K, Ozaslan M, Aoues AEK. (2016). In vivo amelioration of oxidative stress by Artemisia absinthium L. administration on mercuric chloride toxicity in brain regions. J Biol Sci16: 167–177.Search in Google Scholar

Harisa GI, Mariee AD, Abo-Salem OM, Attiaa SM. (2014). Erythrocyte nitric oxide synthase as a surrogate marker for mercury-induced vascular damage: the modulatory effects of naringin. Environ Toxicol29: 1314–1422.Search in Google Scholar

Heinz GH, Hoffman DJ, Klimstra JD, Stebbins KR, Kondrad SL, Erwin CA. (2012). Hormesis associated with a low dose of methylmercury injected into mallard eggs. Arch Environ Contam Toxicol62: 141–144.Search in Google Scholar

Helmcke KJ, Aschner M. (2010). Hormetic effect of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol248: 156–64.Search in Google Scholar

Ibegbu AO, Micheal A, Abdulrazaq AA, Daniel B, Sadeeq AA, Peter A, Hamman WO, Umana UE, Musa SA. (2014). Ameliorative effect of ascorbic acid on mercury chloride induced changes on the spleen of adult wistar rats. J Exp Clin Anatomy13: 60–65.Search in Google Scholar

Jacob S, Thangarajan S. (2017). Effect of gestational intake of fisetin (3,3’,4’,7-Tetrahydroxyflavone) on developmental methyl mercury neurotoxicity in F1 generation rats. Biol Trace Elem Res177: 297–315.Search in Google Scholar

Jagadeesan G, Kavitha AV, Subashini J. (2005). FT-IR Study of the influence of Tribulus terrestris on mercury intoxicated mice, Mus musculus liver. Trop Biomed22: 15–22.Search in Google Scholar

Jagadeesan G, Kavitha AV. (2006). Recovery of phosphatase and transaminase activity of mercury intoxicated Mus musculus (Linn.) liver tissue by Tribulus terrestris (Linn.) (Zygophyllaceae) extract. Trop Biomed23: 45–51.Search in Google Scholar

Joshi D, Mittal DK, Shukla S, Srivastav SK, Dixit VA. (2017b). Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach. Exp Toxicol Pathol69: 373–382.10.1016/j.etp.2017.02.00928336172Search in Google Scholar

Joshi D, Srivastav SK, Belemkar S, Dixit VA. (2017a). Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach. Biomed Pharmacother91: 645–655.10.1016/j.biopha.2017.04.10828494418Search in Google Scholar

Júnior JG, Coutinho HD, Boris TC, Cristo JS, Pereira NL, Figueiredo FG, Cunha FA, Aquino PE, Nascimento PA, Mesquita FJ, Moreira PH, Coutinho ST, Souza IT, Teixeira GC, Ferreira NM, Farina EO, Torres CM, Holanda VN, Pereira VS, Guedes MI. (2016). Chemical characterization and cytoprotective effect of the hydroethanol extract from Annona coriacea Mart. (Araticum). Pharmacognosy Res8: 253–257.Search in Google Scholar

Kavitha AV, Jagadeesan G. (2006). Role of Tribulus terrestris (Linn.) (Zygophyllacea) against mercuric chloride induced nephrotoxicity in mice, Mus musculus (Linn.). J Environ Biol27: 397–400.Search in Google Scholar

Kim W, Kim DW, Yoo DY, Jung HY, Kim JW, Kim DW, Choi JH, Moon SM, Yoon YS, Hwang IK. (2015). Antioxidant effects of Dendropanax morbifera Léveille extract in the hippocampus of mercury-exposed rats. BMC Complement Altern Med15: 247.Search in Google Scholar

Kumar RBS, Kar B, Dolai N, Karmakar I, Bhattacharya S, Haldar PK. (2015). Antitumor activity and antioxidant status of Streblus asper bark against Dalton’s ascitic lymphoma in mice. Interdiscip Toxicol8: 125–130.Search in Google Scholar

Lakshmi BV, Sudhakar M, Nireesha G. (2014). Modification of mercury-induced biochemical alterations by Triticum aestivum Linn in rats. Indian J Physiol Pharmacol58: 423–436.Search in Google Scholar

Lee J, Lee SJ, Lim KT. (2014). Preventive effects of ZPDC glycoprotein (24 kDa) on hepatotoxicity induced by mercury chloride in vitro and in vivo. Cell Biochem Funct32: 520–529.Search in Google Scholar

Lee JH, Moniruzzaman M, Yun H, Lee S, Park Y, Bai SC. (2016). Dietary vitamin C reduced mercury contents in the tissues of juvenile olive flounder (Paralichthys olivaceus) exposed with and without mercury. Environ Toxicol Pharmacol45: 8–14.Search in Google Scholar

Linares AF, Loikkanen J, Jorge MF, Soria RB, Novoa AV. (2004). Antioxidant and neuroprotective activity of the extract from the seaweed, Halimeda incrassata (Ellis) Lamouroux, against in vitro and in vivo toxicity induced by methyl-mercury. Vet Hum Toxicol46:1–5.Search in Google Scholar

Liu W, Xu Z, Li H, Guo M, Yang T, Feng S, Xu B, Deng Yu. (2017). Protective effects of curcumin against mercury-induced hepatic injuries in rats, involvement of oxidative stress antagonism, and Nrf2-ARE pathway activation. Hum Exp Toxicol36: 949–966,.Search in Google Scholar

Liu W, Xu Z, Yang H, Deng Y, Xu B, Wei Y. (2011). The protective effects of tea polyphenols and schisandrin B on nephrotoxicity of mercury. Biol Trace Elem Res143: 1651–1665.Search in Google Scholar

Moneim AEA. (2015). The neuroprotective effect of berberine in mercury-induced neurotoxicity in rats. Metab Brain Dis30: 935–42.Search in Google Scholar

Mostafalou S, Abdollahi M. (2013). Environmental pollution by mercury and related health concerns: Renotice of a silent threat. Arh Hig Rada Toksikol64: 179–181.Search in Google Scholar

Necib Y, Bahi A, Zerizer S. (2013). Amelioration of mercuric chloride toxicity on rat liver. With argan oil and sodium selenite supplements. Int J Pharm Bio Sci4 (B): 839–849.Search in Google Scholar

Officioso A, Tortora F and Manna C. (2016). Nutritional aspects of food toxicology: mercury toxicity and protective effects of olive oil hydroxytyrosol. J Nutr Food Sci6: 539.Search in Google Scholar

Othman MS, Safwat G, Aboulkhair M, Abdel Moneim AE. (2014). The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats. Food Chem Toxicol69: 175–181.Search in Google Scholar

Owoeye O, Arinola GO. (2017). A vegetable, Launaea taraxacifolia, mitigated mercuric chloride alteration of the microanatomy of rat brain. J Diet Suppl14: 613–625.Search in Google Scholar

Patel TA, Rao MV. (2015). Ameliorative effect of certain antioxidants against mercury induced genotoxicity in peripheral blood lymphocytes. Drug Chem Toxicol38: 408–414.Search in Google Scholar

Patrick L. (2002). Mercury toxicity and antioxidants: part I: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Alt Med Rev7: 456–471.Search in Google Scholar

Pinho AI, Oliveira CS, Lovato FL, Waczuk EP, Piccoli BC, Boligon AA, Leite NF, Coutinho HDM, Posser T, Da Rocha JBT, Franco JL. (2017). Antioxidant and mercury chelating activity of Psidium guajava var. pomifera L. leaves hydroalcoholic extract. J Toxicol Environ Health A80: 1301–1313.Search in Google Scholar

Rafati-Rahimzadeh M, Rafati-Rahimzadeh M, Kazemi S Moghadamnia AA. (2014). Current approaches of the management of mercury poisoning: need of the hour. DARU J Pharm Sci22: 46.Search in Google Scholar

Rao MV, Chinoy NJ, Suthar MB, Rajvanshi MI. (2001). Role of ascorbic acid on mercuric chloride-induced genotoxicity in human blood cultures. Toxicol In Vitro15: 649–654.Search in Google Scholar

Rao MV, Sharma PS. (2001). Protective effect of vitamin E against mercuric chloride reproductive toxicity in male mice. Reprod Toxicol15: 705–12.Search in Google Scholar

Sabarathinam J, Vishnu Riya V, Gayathri R. (2016). Mercury poisoning and management: a systematic review. Asian J Pharm Clin Res9: 8–12.Search in Google Scholar

Sakaue M, Mori N, Okazaki M, Kadowaki E, Kaneko T, Hemmi N, Sekiguchi H, Maki T, Ozawa A, Hara S, Arishima K, Yamamoto M. (2011). Vitamin K has the potential to protect neurons from methylmercury-induced cell death in vitro. J Neurosci Res89: 1052–1058.Search in Google Scholar

Sener G, Sehirli O, Tozan A, Velioğlu-Ovunç A, Gedik N, Omurtag GZ. (2007). Ginkgo biloba extract protects against mercury(II)-induced oxidative tissue damage in rats. Food Chem Toxicol45: 543–50.Search in Google Scholar

Sharma MK, Kumar M, Kumar A. (2002). Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian J Exp Biol40: 1079–1082.Search in Google Scholar

Shettigar NB, Das S, Rao NB, Rao SB. (2015). Thymol, a monoterpene phenolic derivative of cymene, abrogates mercury-induced oxidative stress resultant cytotoxicity and genotoxicity in hepatocarcinoma cells. Environ Toxicol30: 968–980.Search in Google Scholar

Shin YJ, Kim JJ, Kim YJ, Kim WH, Park EY, Kim IY, Shin HS, Kim KS, Lee EK, Chung KH, Lee BM, Kim HS. (2015). Protective effects of quercetin against HgCl2-Induced nephrotoxicity in Sprague-Dawley rats. J Med Food18: 524–534.Search in Google Scholar

Singh KP, Bhattacharya S, Sharma P. (2014). Assessment of heavy metal contents of some Indian medicinal plants. American-Eurasian J Agric Environ Sci14: 1125–1129.Search in Google Scholar

Sobral-Souza CE, Leite NF, Cunha FAB, Pinho AI, Albuquerque RS, Carneiro JNP, Menezes IRA, Costa JGM, Franco JL, Coutinho HDM. (2014). Cytoprotective effect against mercury chloride and bioinsecticidal activity of Eugenia jambolana Lam. Arabian J Chem7: 165–170.Search in Google Scholar

Sridhar MP, Nandakumar N, Rengarajan T, Balasubramanian MP. (2013). Amelioration of mercuric chloride induced oxidative stress by Hygrophila auriculata (K.Schum) Heine via modulating the oxidant – antioxidant imbalance in rat liver. J Biochem Tech4: 622–627Search in Google Scholar

Sumathi T, Shobana C, Christinal J, Anusha C. (2012). Protective effect of Bacopa monniera on methyl mercury-induced oxidative stress in cerebellum of rats. Cell Mol Neurobiol32: 979–87.Search in Google Scholar

Tamer M, Saad M. (2013). Effect of curcumin on some heavy metals induced renal and testicular injuries in male rats. Egyptian J Hosp Med53: 770–781.Search in Google Scholar

Tan Q, Liu Z, Li H, Liu Y, Xia Z, Xiao Y, Usman M, Du Y, Bi H, Wei L. (2018). Hormesis of mercuric chloride-human serum albumin adduct on N9 microglial cells via the ERK/MAPKs and JAK/STAT3 signaling pathways. Toxicol408: 62–69.Search in Google Scholar

Thiagarajan K, Gamit N, Mandal S, Ayyathan DM, Chandrasekaran R. (2018). Amelioration of methylmercury induced neural damage by essential oil of Selinum vaginatum (Edgew) C. B. Clarke. Pak J Pharm Sci31: 399–404.Search in Google Scholar

Vetvicka V, Vetvickova J. (2009). Effects of glucan on immunosuppressive actions of mercury. J Med Food12: 1098–104.Search in Google Scholar

Yang D, Tan X, Lv Z, Liu B, Baiyun R, Lu J, Zhang Z. (2016). Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity. Scientific Reports6: 37157.Search in Google Scholar

Yang H, Xu Z, Liu W, Deng Y, Xu B. (2011). The protective role of procyanidins and lycopene against mercuric chloride renal damage in rats. Biomed Environ Sci24: 550–559.Search in Google Scholar

Yang H, Xu Z, Liu W, Wei Y, Deng Y, Xu B. (2012). Effect of grape seed proanthocyanidin extracts on methylmercury-induced neurotoxicity in rats. Biol Trace Elem Res147: 156–164.Search in Google Scholar

Zhai Q, Narbad A, Chen W. (2015). Dietary strategies for the treatment of cadmium and lead toxicity. Nutrients7: 552–571.Search in Google Scholar

Zhang H, Tan X, Yang D, Lu J, Liu B, Baiyun R, Zhang Z. (2017). Dietary luteolin attenuates chronic liver injury induced by mercuric chloride via the Nrf2/NF-κB/P53 signaling pathway in rats. Oncotarget8: 40982–40993.Search in Google Scholar

Zhang Y, Lu R, Liu W, Wu Y, Qian H, Zhao X, Wang S, Xing G. (2013). Hormetic effects of acute methylmercury exposure on GRP78 expression in rat brain cortex. Dose-Response11: 109–120.Search in Google Scholar

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