Antidotal effects of thymoquinone against neurotoxic agents

Abdel-Zaher AO, Farghaly HS, Farrag MM, Abdel-Rahman MS, Abdel-Wahab BA. (2017). A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice. Biomed Pharmacother88: 553–561.10.1016/j.biopha.2017.01.009Search in Google Scholar

Abdel-Zaher AO, Mostafa MG, Farghly HM, Hamdy MM, Omran GA, Al-Shaibani NK. (2013). Inhibition of brain oxidative stress and inducible nitric oxide synthase expression by thymoquinone attenuates the development of morphine tolerance and dependence in mice. Eur J Pharmacol702: 62–70.10.1016/j.ejphar.2013.01.036Search in Google Scholar

Adewale OO, Brimson JM, Odunola OA, Gbadegesin MA, Owumi SE, Isidoro C, Tencomnao T. (2015). The Potential for Plant Derivatives against Acrylamide Neurotoxicity. Phytother Res29: 978–85.10.1002/ptr.5353Search in Google Scholar

Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed3: 337–352.10.1016/S2221-1691(13)60075-1Search in Google Scholar

Akhtar M, Maikiyo AM, Najmi AK, Khanam R, Mujeeb M, Aqil M.. (2013). Neuroprotective effects of chloroform and petroleum ether extracts of Nigella sativa seeds in stroke model of rat. J Pharm Bioallied Sci5: 119–125.10.4103/0975-7406.111825Search in Google Scholar

Al Mamun A, Hashimoto M, Katakura M, Hossain S, Shido O. (2015). Neuroprotective effect of thymoquinone against glutamate-induced toxicity in SHSY5Y cells. Curr Top Nutraceut Res13: 143.Search in Google Scholar

Alekseenko AV, Lemeshchenko VV, Pekun TG, Waseem TV, Fedorovich SV. (2012). Glutamate-induced free radical formation in rat brain synaptosomes is not dependent on intrasynaptosomal mitochondria membrane potential. Neurosci Lett513: 238–242.10.1016/j.neulet.2012.02.051Search in Google Scholar

Antonio AM, Druse MJ. (2008). Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons. Brain Res1204: 16–23.10.1016/j.brainres.2008.02.018Search in Google Scholar

Asaduzzaman Khan M, Tania M, Fu S, Fu J. (2017). Thymoquinone, as an anticancer molecule: from basic research to clinical investigation. Oncotarget8: 51907–51919.10.18632/oncotarget.17206Search in Google Scholar

Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH. (2003). Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol26: 87–98.10.1081/DCT-120020404Search in Google Scholar

Bajo M, Crawford EF, Roberto M, Madamba SG, Siggins GR. (2006). Chronic morphine treatment alters expression of N-methyl-D-aspartate receptor subunits in the extended amygdala. J Neurosci Res83: 532–537.10.1002/jnr.20756Search in Google Scholar

Bargi R, Asgharzadeh F, Beheshti F, Hosseini M, Sadeghnia HR, Khazaei M. (2017). The effects of thymoquinone on hippocampal cytokine level, brain oxidative stress status and memory deficits induced by lipopolysaccharide in rats. Cytokine96: 173–184.10.1016/j.cyto.2017.04.015Search in Google Scholar

Chesnokova V, Pechnick RN, Wawrowsky K. (2016). Chronic peripheral inflammation, hippocampal neurogenesis, and behavior. Brain Behav Immun58: 1–8.10.1016/j.bbi.2016.01.017Search in Google Scholar

Chindo BA, Schröder H, Becker A. (2015). Methanol extract of Ficus platyphylla ameliorates seizure severity, cognitive deficit and neuronal cell loss in pentylenetetrazole-kindled mice. Phytomed22: 86–93.10.1016/j.phymed.2014.10.005Search in Google Scholar

Conti AC, Lowing JL, Susick LL, Bowen SE. (2012). Investigation of calcium-stimulated adenylyl cyclases 1 and 8 on toluene and ethanol neurobehavioral actions. Neurotoxicol Teratol34: 481–8.10.1016/j.ntt.2012.06.005Search in Google Scholar

Coon S, Stark A, Peterson E, Gloi A, Kortsha G, Pounds J, Chettle D, Gorell J. (2006). Whole-body lifetime occupational lead exposure and risk of Parkinson’s disease. Environ Health Perspect114: 1872.10.1289/ehp.9102Search in Google Scholar

Deleu D, Hanssens Y. (2000). Cerebellar dysfunction in chronic toluene abuse: beneficial response to amantadine hydrochloride. J Toxicol: ClinToxicol38: 37–41.10.1081/CLT-100100913Search in Google Scholar

Dhir A. (2012). Pentylenetetrazol (PTZ) kindling model of epilepsy. Curr Protoc Neurosci9: Unit9.37.10.1002/0471142301.ns0937s58Search in Google Scholar

Echeverria D, Fine L, Langolf G, Schork T, Sampaio C. (1991). Acute behavioural comparisons of toluene and ethanol in human subjects. Occup Environ Med48: 750–761.10.1136/oem.48.11.750Search in Google Scholar

Esen F, Orhun G, Ozcan PE, Senturk E, Kucukerden M, Giris M, Akcan U, Yilmaz CU, Orhan N, Arican N, Kaya M, Gazioglu SB, Tuzun E. (2017). Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis. Intensive Care Med Exp5: 1.10.1186/s40635-016-0114-1Search in Google Scholar

Evans EB, Balster RL. (1991). CNS depressant effects of volatile organic solvents. Neurosci Biobehav Rev15: 233–241.10.1016/S0149-7634(05)80003-XSearch in Google Scholar

Farkhondeh T, Samarghandian S, Borji A. (2017). An overview on cardioprotective and anti-diabetic effects of thymoquinone. Asian Pac J Trop Med10: 849–854.10.1016/j.apjtm.2017.08.020Search in Google Scholar

Farkhondeh T, Samarghandian S, Sadighara P. (2015). Lead exposure and asthma: an overview of observational and experimental studies. Toxin Rev34: 6–10.10.3109/15569543.2014.958756Search in Google Scholar

Flanagan R, Ruprah M, Meredith T, Ramsey J. (1989). An introduction to the clinical toxicology of volatile substances. Drug Safety5: 359–383.10.2165/00002018-199005050-00005Search in Google Scholar

Flora G, Gupta D, Tiwari A. (2012). Toxicity of lead: a review with recent updates. Interdiscip Toxicol5: 47–58.10.2478/v10102-012-0009-2Search in Google Scholar

Gaweł S, Wardas M, Niedworok E, Wardas P. (2003). Malondialdehyde (MDA) as a lipid peroxidation marker. Wiadomosci lekarskie57: 453–455.Search in Google Scholar

Greenberg MM. (1997). The central nervous system and exposure to toluene: a risk characterization. Environ Res72: 1–7.10.1006/enrs.1996.3686Search in Google Scholar

Guzmán GR, Ortiz-Acevedo A, Ricardo A, Rojas LV, Lasalde-Dominicci JA. (2006). The polarity of lipid-exposed residues contributes to the functional differences between Torpedo and muscle-type nicotinic receptors. J Membr Biol214: 131–138.10.1007/s00232-006-0051-0Search in Google Scholar

Hamdy NM, Taha RA. (2009). Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats. Pharmacol84: 127–134.10.1159/000234466Search in Google Scholar

Hassanzadeh P, Arbabi E, Rostami F. (2014). The ameliorative effects of sesamol against seizures, cognitive impairment and oxidative stress in the experimental model of epilepsy. Iran J Basic Med Sci17: 100.Search in Google Scholar

Hester SD, Johnstone AF, Boyes WK, Bushnell PJ, Shafer TJ. (2011). Acute toluene exposure alters expression of genes in the central nervous system associated with synaptic structure and function. Neurotoxicol Teratol33: 521–9.10.1016/j.ntt.2011.07.008Search in Google Scholar

Ibi M, Matsuno K, Matsumoto M, Sasaki M, Nakagawa T, Katsuyama M, Iwata K, Zhang J, Kaneko S, Yabe-Nishimura C. (2011). Involvement of NOX1/ NADPH oxidase in morphine-induced analgesia and tolerance. J Neurosci31: 18094–18103.10.1523/JNEUROSCI.4136-11.2011Search in Google Scholar

Jain S, Sangma T, Shukla SK, Mediratta PK. (2015). Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rats. Nutr Neurosci18: 210–216.10.1179/1476830514Y.0000000113Search in Google Scholar

Jones K, Smith D, Ulleland C, Streissguth A. (1973). Pattern of malformation in offspring of chronic alcoholic mothers. Lancet301: 1267–1271.10.1016/S0140-6736(73)91291-9Search in Google Scholar

Kamran S, Bakshi R. (1998). MRI in chronic toluene abuse: low signal in the cerebral cortex on T2-weighted images. Neuroradiol40: 519–521.10.1007/s002340050637Search in Google Scholar

Kanter M. (2011a). Protective effects of thymoquinone on the neuronal injury in frontal cortex after chronic toluene exposure. J Mol Histol42: 39–46.10.1007/s10735-010-9305-321120684Search in Google Scholar

Kanter M. (2011b). Thymoquinone attenuates lung injury induced by chronic toluene exposure in rats. Toxicol Ind Health27: 387–395.10.1177/074823371038763021088054Search in Google Scholar

Kanter, M. (2008). Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats. Neurochem Res33: 579–588.10.1007/s11064-007-9481-zSearch in Google Scholar

Kaur H, Onsare JG, Sharma V, Arora DS. (2015). Isolation, purification and characterization of novel antimicrobial compound 7-methoxy-2, 2-dimethyl-4-octa-4’, 6’-dienyl-2 H-napthalene-1-one from Penicillium sp. and its cytotoxicity studies. AMB Express5: 40.10.1186/s13568-015-0120-9Search in Google Scholar

Kurtzman TL, Otsuka KN, Wahl RA. (2001). Inhalant abuse by adolescents. J Adolesc Health28: 170–180.10.1016/S1054-139X(00)00159-2Search in Google Scholar

Lidsky TI, Schneider JS. (2003). Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain126: 5–19.10.1093/brain/awg014Search in Google Scholar

Lopachin RM. (2005). Acrylamide neurotoxicity: neurological, morhological and molecular endpoints in animal models. Adv Exp Med Biol561: 21–37.10.1007/0-387-24980-X_2Search in Google Scholar

Mansour M, Ginawi O, El-Hadiyah T, El-Khatib A, Al-Shabanah O, Al-Sawaf H. (2001). Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone. Res Commun Mol Pathol Pharmacol110: 239–252.Search in Google Scholar

Mehri S, Shahi M, Razavi BM, Hassani FV, Hosseinzadeh H. (2014). Neuroprotective effect of thymoquinone in acrylamide-induced neurotoxicity in Wistar rats. Iran J Basic Med Sci17: 1007.Search in Google Scholar

Miller MW. (1986). Effects of alcohol on the generation and migration of cerebral cortical neurons. Science233: 1308–1312.10.1126/science.3749878Search in Google Scholar

Miller MW. (1996). Mechanisms of ethanol induced neuronal death during development: from the molecule to behavior. Alcohol Clin Exp Res20: 128A–132A.10.1111/j.1530-0277.1996.tb01762.xSearch in Google Scholar

Mori E, Bagcivan I, Durmus N, Altun A, Gursoy S. (2011). The nitric oxide–cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine. Can J Physiol Pharmacol89: 89–95.10.1139/Y10-109Search in Google Scholar

Mori T, Ito S, Matsubayashi K, Sawaguchi T. (2007). Comparison of nitric oxide synthase inhibitors, phospholipase A2 inhibitor and free radical scavengers as attenuators of opioid withdrawal syndrome. Behav Pharmacol18: 725–729.10.1097/FBP.0b013e3282f18da6Search in Google Scholar

Murray F, Harrison NJ, Grimwood S, Bristow LJ, Hutson PH. (2007). Nucleus accumbens NMDA receptor subunit expression and function is enhanced in morphine-dependent rats. Eur J Pharmacol 562: 191–197.10.1016/j.ejphar.2007.01.027Search in Google Scholar

Naseer M, Lee H, Ullah N, Ullah I, Park M, Kim S, Kim M. (2010). Ethanol and PTZ effects on siRNA-mediated GABAB1 receptor: Down regulation of intracellular signaling pathway in prenatal rat cortical and hippocampal neurons. Synapse64: 181–190.10.1002/syn.20712Search in Google Scholar

Özek M, Üresin Y, Güngör M. (2003). Comparison of the effects of specific and nonspecific inhibition of nitric oxide synthase on morphine analgesia, tolerance and dependence in mice. Life Sci72: 1943–1951.10.1016/S0024-3205(03)00100-0Search in Google Scholar

Özmen İ, Nazıroğlu M, Alici HA, Şahin F, Cengiz M, Eren I. (2007). Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress. Neurochem Res32: 19–25.10.1007/s11064-006-9217-5Search in Google Scholar

Qu X, Xu C, Wang H, Xu J, Liu W, Wang Y, Jia X, Xie Z, Xu Z, Ji C. (2012). Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane-induced spatial learning/memory impairment. Neurochem Res38: 59–73.10.1007/s11064-012-0889-8Search in Google Scholar

Radad K, Hassanein K, Al-Shraim M, Moldzio R, Rausch WD. (2014). Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats. Exp Toxicol Pathol66: 13–17.10.1016/j.etp.2013.07.002Search in Google Scholar

Ramachandran V, Watts LT, Maffi SK, Chen J, Schenker S, Henderson G. (2003). Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons. J Neurosci Res74: 577–588.10.1002/jnr.10767Search in Google Scholar

Reckziegel P, Dias VT, Benvegnú D, Boufleur N, Silva Barcelos RC, Segat HJ. (2011). Locomotor damage and brain oxidative stress induced by lead exposure are attenuated by gallic acid treatment. Toxicol Lett203: 74–81.10.1016/j.toxlet.2011.03.006Search in Google Scholar

Salim S. (2017). Oxidative Stress and the Central Nervous System. J Pharmacol Exp Ther360: 201–205.10.1124/jpet.116.237503Search in Google Scholar

Samarghandian S, Azimi-Nezhad M, Borji A, Samini M, Farkhondeh T. (2017). Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats. BMC Complement Altern Med17: 249.10.1186/s12906-017-1753-9Search in Google Scholar

Samarghandian S, Samini F, Azimi-Nezhad M, Farkhondeh T. (2017). Anti-oxidative effects of safranal on immobilization-induced oxidative damage in rat brain. Neurosci Lett659: 26–32.10.1016/j.neulet.2017.08.065Search in Google Scholar

Sepulveda MJ, Hernandez L, Rada P, Tucci S, Contreras E. (1998). Effect of precipitated withdrawal on extracellular glutamate and aspartate in the nucleus accumbens of chronically morphine-treated rats: an in vivo microdialysis study. Pharmacol Biochem Behav60: 255–262.10.1016/S0091-3057(97)00550-9Search in Google Scholar

Shiotsuka RN, Warren DL, Halliburton AT, Sturdivant DW. (2000). A comparative respiratory sensitization study of 2,4- and 2,6-toluene diisocyanate using guinea pigs. Inhal Toxicol 12: 605–15.10.1080/08958370050030976Search in Google Scholar

Singh A, Kumar A. (2015). Microglial inhibitory mechanism of coenzyme Q10 against Aβ (1-42) induced cognitive dysfunctions: possible behavioral, biochemical, cellular, and histopathological alterations. Front Pharmacol6: 268.10.3389/fphar.2015.00268Search in Google Scholar

Song X, Zhou B, Zhang P, Lei D, Wang Y, Yao G, Hayashi T, Xia M, Tashiro SI, Onodera S. (2016). Protective Effect of Silibinin on Learning and Memory Impairment in LPS-Treated Rats via ROS-BDNF-TrkB Pathway. Neurochem Res41: 1662–1672.10.1007/s11064-016-1881-5Search in Google Scholar

Udhayabanu T, Manole A, Rajeshwari M, Varalakshmi P, Houlden H, Ashok-kumar B. (2017). Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases. J Clin Med6: pii: E52.10.3390/jcm6050052Search in Google Scholar

Ullah I, Ullah N, Naseer MI, Lee HY, Kim MO. (2012). Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons. BMC Neurosci 13: 11.10.1186/1471-2202-13-11Search in Google Scholar

Valero J, Mastrella G, Neiva I, Sánchez S, Malva JO. (2014). Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory. Front Neurosci8: 83.10.3389/fnins.2014.00083Search in Google Scholar

Wang L, Xu J, Tian Y, Wu H, Liu Y. (2007). Protective effect of N-acetylcysteine against lipopolysaccharide injury in hepatocytes of neonatal mice. Zhonghua Er Ke Za Zhi45: 30–33.Search in Google Scholar

Wang X, Quinn PJ. (2010). Endotoxins: lipopolysaccharides of gram-negative bacteria. Endotoxins: Structure, Function and Recognition. Springer 3–25.10.1007/978-90-481-9078-2_1Search in Google Scholar

Wen ZH, Chang YC, Cherng CH, Wang JJ, Tao PL, Wong CS. (2004). Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats. Brain Res995: 253–259.10.1016/j.brainres.2003.10.008Search in Google Scholar

Wolf O, Atsak P, Quervain D, Roozendaal B, Wingenfeld K. (2016). Stress and memory: a selective review on recent developments in the understanding of stress hormone effects on memory and their clinical relevance. J Neuro-Endocrinol28(8). doi: 10.1111/jne.12353.10.1111/jne.1235326708929Search in Google Scholar

Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, Mcpherson CA, Harry J, Rice DC, Maloney B, Chen D. (2008). Alzheimer’s disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J Neurosci28: 3–9.10.1523/JNEUROSCI.4405-07.2008Search in Google Scholar

Yamanouchi N, Okada SI, Kodama K, Hirai S, Sekine H, Murakami A, Komatsu N, Sakamoto T, Sato T. (1995). White matter changes caused by chronic solvent abuse. Am J Neuroradiol16: 1643–1649.Search in Google Scholar

Yan X, Huang G, Liu Q, Zheng J, Chen H, Huang Q, Chen J, Huang H. (2017). Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice. Pharm Biol55: 1171–1176.10.1080/13880209.2017.1288262Search in Google Scholar

Young C, Roth KA, Klocke BJ, West T, Holtzman DM, Labruyere J, Qin YQ, Dikranian K, Olney JW. (2005). Role of caspase-3 in ethanol-induced developmental neurodegeneration. Neurobiol Dis20: 608–614.10.1016/j.nbd.2005.04.014Search in Google Scholar

Zabedah M, Razak M, Zakiah I, Zuraidah A. (2001). Profile of solvent abusers (glue sniffers) in East Malaysia. Malays J Pathol23: 105–109.Search in Google Scholar

Zhu YJ, Zeng T, Zhu YB, Yu SF, Wang QS, Zhang LP, Guo X, Xie KQ. (2008). Effects of acrylamide on the nervous tissue antioxidant system and sciatic nerve electrophysiology in the rat. Neurochem Res33: 2310–2317.10.1007/s11064-008-9730-9Search in Google Scholar