<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Free radicals are one of the causes of chronic and degenerative diseases. Antioxidants can protect the progression of free radical mediated disorders. The aim of this study was to evaluate the antioxidant activity of Spirogyra neglecta (Hassall) Kützing in rats. The rats were divided into 5 groups. Group 1 served as control. Groups 2 and 3 were administered hot water extract of S. neglecta at 50 and 200 mg/kg bw, respectively, while groups 4 and 5 were fed 1% and 4% S. neglecta mixed diet, resp., for 13 weeks. Antioxidant enzymes were evaluated in livers of the rats. The activities of catalase and glutathione reductase were significantly increased in the group fed 50 mg/kg of the extract, compared with the control group. Glutathione peroxidase activity was also significantly higher in the group fed 50 and 200 mg/kg of the extract. The study suggests that S. neglecta may enhance antioxidant systems in the rat liver.</p></abstract>

Free radicals are one of the causes of chronic and degenerative diseases. Antioxidants can protect the progression of free radical mediated disorders. The aim of this study was to evaluate the antioxidant activity of Spirogyra neglecta (Hassall) Kützing in rats. The rats were divided into 5 groups. Group 1 served as control. Groups 2 and 3 were administered hot water extract of S. neglecta at 50 and 200 mg/kg bw, respectively, while groups 4 and 5 were fed 1% and 4% S. neglecta mixed diet, resp., for 13 weeks. Antioxidant enzymes were evaluated in livers of the rats. The activities of catalase and glutathione reductase were significantly increased in the group fed 50 mg/kg of the extract, compared with the control group. Glutathione peroxidase activity was also significantly higher in the group fed 50 and 200 mg/kg of the extract. The study suggests that S. neglecta may enhance antioxidant systems in the rat liver.

Evaluation of hepatic antioxidant capacities of Spirogyra neglecta (Hassall) Kützing in rats

1Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand

Faculty of Fisheries Technology and Aquatic Resources, Maejo University, Chiang Mai, Thailand

Interdisciplinary Toxicology

Free radicals are one of the causes of chronic and degenerative diseases. Antioxidants can protect the progression of free radical mediated disorders. The aim...

Evaluation of hepatic antioxidant capacities of Spirogyra neglecta (Hassall) Kützing in rats

Published Online: Feb 27, 2014

Page range: 152 - 156

DOI: https://doi.org/10.2478/intox-2013-0024

This content is open access.