<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Optimal treatment of heart failure (HF) is a continuous challenge. Pharmacological progress, interventional or surgical procedures, kinesio-therapeutic rehabilitation have modestly improved the prognosis of HF with reduced ejection fraction (EF), and patients with HF with preserved EF, or those hospitalized for HF regardless of EF still have a high mortality risk<sup>1,2</sup>. The association to the standard treatment of HF either of CoQ10 (CoQ10) or selenium has been evaluated over the last 30 years in many small and non-statistical powered studies. The recent publication of randomized trials Q-SYMBYO and Kisel-10 renewed interest in these supplements. The article aims to synthesize literature data on the role and mechanism of action of CoQ10 and selenium in HF as well as the results of the published trials and meta-analyses, focusing on the latest.</p></abstract>

Optimal treatment of heart failure (HF) is a continuous challenge. Pharmacological progress, interventional or surgical procedures, kinesio-therapeutic rehabilitation have modestly improved the prognosis of HF with reduced ejection fraction (EF), and patients with HF with preserved EF, or those hospitalized for HF regardless of EF still have a high mortality risk1,2. The association to the standard treatment of HF either of CoQ10 (CoQ10) or selenium has been evaluated over the last 30 years in many small and non-statistical powered studies. The recent publication of randomized trials Q-SYMBYO and Kisel-10 renewed interest in these supplements. The article aims to synthesize literature data on the role and mechanism of action of CoQ10 and selenium in HF as well as the results of the published trials and meta-analyses, focusing on the latest.

Coenzyme Q10 and Selenium in Heart Failure – A New Perspective

Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Coenzyme Q10 and Selenium in Heart Failure \u2013 A New Perspective"}

Optimal treatment of heart failure (HF) is a continuous challenge. Pharmacological progress, interventional or surgical procedures, kinesio-therapeutic...

Coenzyme Q10 and Selenium in Heart Failure – A New Perspective

Published Online: Dec 05, 2019

Page range: 41 - 51

DOI: https://doi.org/10.2478/inmed-2019-0083

Keywords
Coenzyme Q10, Selenium, Heart failure

© 2019 Mihaela Ioana Bolog, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Coenzyme Q10 and Selenium in Heart Failure – A New Perspective

Published Online: Dec 05, 2019

Page range: 41 - 51

DOI: https://doi.org/10.2478/inmed-2019-0083

KeywordsCoenzyme Q10, Selenium, Heart failure

© 2019 Mihaela Ioana Bolog, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Coenzyme Q10, Selenium, Heart failure