<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background.</bold> It is well known that the NT-proBNP in obese subjects is much lower than in normal weight subjects, making difficult to interpret it. In current practice the patients are frequently obese. In these conditions, a new biomarker, not influenced by weight, could be useful in acute-decompensated heart failure (ADHF).<bold>Aim.</bold> To determine CA-125 changes in obese and normal weight patients with ADHF.<bold>Method.</bold> The study group included 110 patients (mean age 72±10 years, 63% men) with ADHF caused by ischemic cardiomyopathy. The subjects were clinically, ecocardiographically and biologically (NT-proBNP, CA-125) evaluated.<bold>Results.</bold> The mean BMI was 27.6±5.8 kg/m2 and 35 (33%) subjects were obese. CA-125 at admission was 53±33 U/mL and decreased at discharge to 34±17 U/mL, without any difference between males and females.There was a significant difference between NT-proBNP at admission in obese versus normoponderal patients (3207±1432 pg/mL versus 4457±2737 pg/mL (p=0.02)), which was maintained at discharge (1711±816 pg/mL versus 2674±1475 pg/mL (p=0.03)).In the same time, the CA-125 did not show statistically significant differences between obese and normoponderal subjects at admission (56±29 U/mL versus 51±20 U/mL (p=0.63)) and discharge (36±20 U/mL versus 33±16 U/mL (p=0.56)).<bold>Conclusions.</bold> CA-125 could be an useful biomarker in monitoring the obese patients with ADHF, better than NT-proBNP.</abstract>

Background. It is well known that the NT-proBNP in obese subjects is much lower than in normal weight subjects, making difficult to interpret it. In current practice the patients are frequently obese. In these conditions, a new biomarker, not influenced by weight, could be useful in acute-decompensated heart failure (ADHF).Aim. To determine CA-125 changes in obese and normal weight patients with ADHF.Method. The study group included 110 patients (mean age 72±10 years, 63% men) with ADHF caused by ischemic cardiomyopathy. The subjects were clinically, ecocardiographically and biologically (NT-proBNP, CA-125) evaluated.Results. The mean BMI was 27.6±5.8 kg/m2 and 35 (33%) subjects were obese. CA-125 at admission was 53±33 U/mL and decreased at discharge to 34±17 U/mL, without any difference between males and females.There was a significant difference between NT-proBNP at admission in obese versus normoponderal patients (3207±1432 pg/mL versus 4457±2737 pg/mL (p=0.02)), which was maintained at discharge (1711±816 pg/mL versus 2674±1475 pg/mL (p=0.03)).In the same time, the CA-125 did not show statistically significant differences between obese and normoponderal subjects at admission (56±29 U/mL versus 51±20 U/mL (p=0.63)) and discharge (36±20 U/mL versus 33±16 U/mL (p=0.56)).Conclusions. CA-125 could be an useful biomarker in monitoring the obese patients with ADHF, better than NT-proBNP.

A New Biomarker in Acute-Decompensated Heart Failure. Preliminary Study

“Carol Davila” University of Medicine and Pharmacy

Internal Medicine and Cardiovascular Department

Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"A New Biomarker in Acute-Decompensated Heart Failure. Preliminary Study"}

Background. It is well known that the NT-proBNP in obese subjects is much lower than in normal weight subjects, making difficult to interpret it. In current...

A New Biomarker in Acute-Decompensated Heart Failure. Preliminary Study

Published Online: Aug 17, 2019

Page range: 7 - 14

DOI: https://doi.org/10.2478/inmed-2019-0064

Keywords
biomarker, heart failure, NT-proBNP, CA-125

© 2019 Mădălina Ababei et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A New Biomarker in Acute-Decompensated Heart Failure. Preliminary Study

Published Online: Aug 17, 2019

Page range: 7 - 14

DOI: https://doi.org/10.2478/inmed-2019-0064

Keywordsbiomarker, heart failure, NT-proBNP, CA-125

© 2019 Mădălina Ababei et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
biomarker, heart failure, NT-proBNP, CA-125