| DNMT2 |
DNA methylation |
Cytosine + S-Adenosyl-L-methionine DNA- methyltransferase Cytosine-CH3 |
(Geyer et al., 2011) Smp_198180 |
| HDACs |
Histone deacetylation |
HO + N6-acetyl-L-lysyl-[histone] = 2acetate + L-lysyl-[histone] |
SmHDAC1 Smp_005210; SmHDAC3 Smp_093280; SmHDAC8 Smp_091990; (Oger et al., 2008) |
| HAT |
Catalyzes acetylation in lysines of histones and other proteins |
Zinc ion binding Bromodomain Acetyltransferase activity |
AY337317 Smp_105910 (Bertin et al., 2006; Maciel et al., 2004) |
| HMT PRMT |
Protein arginine N-methyltransferase 1 S-adenosyl-L-methionine Methyltransferase . Peptidyl-arginine N-methylation |
Catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). |
Smp_070340 Smp_029240.2 Smp_025550 Smp_171150 Cabezas-Cruz et al., 2014 |
| PTKs |
Phosphorylation of tyrosine protein diversity |
ATP + a protein-L-tyrosine ADP + a protein-L-tyrosine phosphate |
(Avelar et al., 2011) |
| Ubiquitin- conjugating enzymes (Ub-E2) |
Catalyzes the intermediate step of protein ubiquitination |
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine. |
(Costa et al., 2015) |
| UCHs, USPs, OTUs, MJDs |
Involved in ubiquitin processing, in the recovery of modified ubiquitin trapped in inactive forms, and in the recycling of ubiquitin monomers from polyubiquitinated chains DNA repair, cell-cycle control, endocytosis, transcription and protein degradation by the proteasome |
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Glycine of ubiquitin |
(Pereira et al., 2015) |
| HMT PKMT |
Protein lysine methyltransferase (PKMT) |
L-lysyl-[protein] + S-adenosyl-L- methionine = H+ + N6-methyl-L-lysyl- [protein] + S-adenosyl-L-homocysteine |
(Smp _000700) (Whatley et al., 2019) |
| KDM |
Lysine specific demethylase |
Demethylation of 'Lys-27' of H3 and appendant methylation of 'Lys-4' of histone H3, in agreement with recruitment of the PRC1 complex and monoubiquitination of histone H2A |
(Smp_034000) (Lobo-Silva et al., 2020) |
