Clinical case of life-threatening co-infection due to Dirofilaria immitis and Aelurostrongylus abstrusus in a cat: First report of feline heartworm disease in Bulgaria

Atkins, C.E., Atwell, R.B., Dillon, A.R., Genchi, C., Hayasaky, M., Holmes, R.A., Knight, D.H., Lukoff, D.K., McCall, J.W., Slocombe, J.O. (1995): Guidelines for the diagnosis, treatment, and prevention of heartworm (Dirofilaria immitis) infection in cats. In: Soll, M.D., Knight, D.H. (Eds) Proceedings of the heartworm symposium ’95. American Heartworm Society, Batavia, IL, pp. 309–312 Atkins C.E. Atwell R.B. Dillon A.R. Genchi C. Hayasaky M. Holmes R.A. Knight D.H. Lukoff D.K. McCall J.W. Slocombe J.O. 1995 Guidelines for the diagnosis, treatment, and prevention of heartworm (Dirofilaria immitis) infection in cats In Soll M.D. Knight D.H. Eds Proceedings of the heartworm symposium ’95 American Heartworm Society, Batavia, IL pp 309 312Search in Google Scholar

Atkins, C.E., DeFrancesco, T.C., Coats, J.R., Sidley, J.A., Keene, B.W. (2000): Heartworm infection in cats: 50 cases (1985–1997). J. Am. Vet. Med. Assoc., 217(3): 355–358. DOI: 10.2460/javma.2000.217.355 Atkins C.E. DeFrancesco T.C. Coats J.R. Sidley J.A. Keene B.W. 2000 Heartworm infection in cats: 50 cases (1985–1997) J. Am. Vet. Med. Assoc 2173 355 358 10.2460/javma.2000.217.35510935039Open DOISearch in Google Scholar

Diakou, A., Soubasis, N., Chochlios, T., Oikonomidis, I. L., Tselekis, D., Koutinas, C., Karaiosif, R., Psaralexi, E., Tsouloufi, T. K., Brellou, G., Kritsepi-Konstantinou, M., Rallis, T. (2018): Canine and feline dirofilariosis in a highly enzootic area: first report of feline dirofilariosis in Greece. Parasitol. Res., 118(2): 677–682. DOI: 10.1007/s00436-018-6135-9 Diakou A. Soubasis N. Chochlios T. Oikonomidis I. L. Tselekis D. Koutinas C. Karaiosif R. Psaralexi E. Tsouloufi T. K. Brellou G. Kritsepi-Konstantinou M. Rallis T. 2018 Canine and feline dirofilariosis in a highly enzootic area: first report of feline dirofilariosis in Greece Parasitol. Res 1182 677 682 10.1007/s00436-018-6135-930397776Open DOISearch in Google Scholar

Dillon, R., Warner, A.E., Molina, R.M. (1995): Pulmonary parenchymal changes in dogs and cats after experimental transplantation of dead Dirofilaria immitis. In: Soll, M. D., Knight, D. H. (Eds) Proceedings of the heartworm symposium ’95. American Heart-worm Society, Batavia, IL, pp. 97–101 Dillon R. Warner A.E. Molina R.M. 1995 Pulmonary parenchymal changes in dogs and cats after experimental transplantation of dead Dirofilaria immitis In Soll M. D. Knight D. H. Eds Proceedings of the heartworm symposium ’95 American Heart-worm Society Batavia, IL pp 97 101Search in Google Scholar

Dillon, A.R., Brawner Jr, A.R., Robertson-Plouch, C.K., Guerrero, J. (2000): Feline heartworm disease: correlations of clinical signs, serology, and other diagnostic results of a multicentre study. Vet. Ther., 1(3): 176–182. Dillon A.R. Brawner Jr A.R. Robertson-Plouch C.K. Guerrero J. 2000 Feline heartworm disease: correlations of clinical signs, serology, and other diagnostic results of a multicentre study Vet. Ther 13 176 182Search in Google Scholar

Dillon, A.R., Warner, A.E., Brawner, W., Hudson, J., Tillson, M. (2008): Activity of pulmonary intravascular macrophages in cats and dogs with and without Dirofilaria immitis Vet. Parasitol., 158: 171–176. DOI: 10.1016/j.vetpar.2008.09.004 Dillon A.R. Warner A.E. Brawner W. Hudson J. Tillson M. 2008 Activity of pulmonary intravascular macrophages in cats and dogs with and without Dirofilaria immitis Vet. Parasitol 158 171 176 10.1016/j.vetpar.2008.09.00418977090Open DOISearch in Google Scholar

Garrity, S., Lee-Fowler, T., Reinero, C. (2019): Feline asthma and heartworm disease: Clinical features, diagnostics and therapeutics. J. Feline Med. Surg., 21(9): 825–834. DOI: 10.1177/1098612X18823348 Garrity S. Lee-Fowler T. Reinero C. 2019 Feline asthma and heartworm disease: Clinical features, diagnostics and therapeutics J. Feline Med. Surg 219 825 834 10.1177/1098612X1882334831446863Open DOISearch in Google Scholar

Genchi, M., Ferrari, N., Fonti, P., De Francesco, I., Piazza, C., Viglietti, A. (2014): Relation between Aelurostrongylus abstrusus larvae excretion, respiratory and radiographic signs in naturally infected cats. Vet. Parasitol., 206(3-4): 182–187. DOI: 10.1016/j. vetpar.2014.10.030 Genchi M. Ferrari N. Fonti P. De Francesco I. Piazza C. Viglietti A. 2014 Relation between Aelurostrongylus abstrusus larvae excretion, respiratory and radiographic signs in naturally infected cats Vet. Parasitol 2063-4 182 187 10.1016/j.vetpar.2014.10.03025466621Open DOISearch in Google Scholar

Giannelli, A., Capelli, G., Joachim, A., Hinney, B., Losson, B., Kirkova, Z., Rene-Martellet, M., Papadopoulos, E., Farkas, R., Napoli, E., Brianti, E., Tamponi, C., Varcasia, A., Alho, A. M., Carvalho, L. M., Cardoso, L., Maia, C., Mircean, V., Mihalca, A.D., Miro, G., Schnyder, M., Cantacessi, C., Colella, V., Cavalera, M., Latrofa, M.S., Annoscia, G., Knaus, M., Halos, L., Beugnet, F., Otranto, D. (2017): Lungworms and gastrointestinal parasites of domestic cats: a European perspective. Int. J. Parasitol., 47(9): 517–528. DOI: 10.1016/j.ijpara.2017.02.003 Giannelli A. Capelli G. Joachim A. Hinney B. Losson B. Kirkova Z. Rene-Martellet M. Papadopoulos E. Farkas R. Napoli E. Brianti E. Tamponi C. Varcasia A. Alho A. M. Carvalho L. M. Cardoso L. Maia C. Mircean V. Mihalca A.D. Miro G. Schnyder M. Cantacessi C. Colella V. Cavalera M. Latrofa M.S. Annoscia G. Knaus M. Halos L. Beugnet F. Otranto D. 2017 Lungworms and gastrointestinal parasites of domestic cats: a European perspective Int. J. Parasitol 479 517 528 10.1016/j.ijpara.2017.02.00328455237Open DOISearch in Google Scholar

Hnilica, K., Patterson, A. (2017): Small Animal Dermatology. 4^th Edition, St. Louis, Missouri, USA, Elsevier, pp. 110 Hnilica K. Patterson A. 2017 Small Animal Dermatology. 4^th Edition, St Louis, Missouri, USA Elsevier pp 110Search in Google Scholar

Litster, A., Atkins, C., Atwell, R., Buchanan, J. (2005): Radiographic cardiac size in cats and dogs with heartworm disease compared with reference values using the vertebral heart scale method: 53 cases. J. Vet. Cardiol., 7(1): 33–40. DOI: 10.1016/j. jvc.2005.02.002 Litster A. Atkins C. Atwell R. Buchanan J. 2005 Radiographic cardiac size in cats and dogs with heartworm disease compared with reference values using the vertebral heart scale method: 53 cases J. Vet. Cardiol 71 33 40 10.1016/j.jvc.2005.02.00219083316Open DOISearch in Google Scholar

Litster, A.L., Atwell, R.B. (2008): Feline heartworm disease: a clinical review. J. Feline Med. Surg., 10(2): 137–144. DOI: 10.1016/j.jfms.2007.09.007 Litster A.L. Atwell R.B. 2008 Feline heartworm disease: a clinical review J. Feline Med. Surg 102 137 144 10.1016/j.jfms.2007.09.00718042416Open DOISearch in Google Scholar

Le, A.C., Atkins, C.E. (2010): Understanding feline heartworm infection: disease, diagnosis, and treatment. Top. Companion Anim. Med., 25(4): 224–230. DOI: 10.1053/j.tcam.2010.09.003 Le A.C. Atkins C.E. 2010 Understanding feline heartworm infection: disease, diagnosis, and treatment Top. Companion Anim. Med 254 224 230 10.1053/j.tcam.2010.09.00321147476Open DOISearch in Google Scholar

McCall, J.W. (1998): Dirofilarisis in the domestic ferret. Clin. Tech. Small Anim. Pract., 13(2): 109–112. DOI: 10.1016/S1096-2867(98)80015-7 McCall J.W. 1998 Dirofilarisis in the domestic ferret Clin. Tech. Small Anim. Pract 132 109 112 10.1016/S1096-2867(98)80015-79753800Open DOISearch in Google Scholar

McCall, J.W., Genchi, C., Kramer, L.H., Guerero, J., Venco, L. (2008): Heartworm disease in animals and humans. Adv. Parasitol., 66: 193–285. DOI: 10.1016/S0065-308X(08)00204-2 McCall J.W. Genchi C. Kramer L.H. Guerero J. Venco L. 2008 Heartworm disease in animals and humans Adv. Parasitol 66 193 285 10.1016/S0065-308X(08)00204-218486691Open DOISearch in Google Scholar

Montoya-Alonso, J.A., Careton, E., Garcia-Guasch, L., Exposito, J., Armario, B., Morchon, R., Simon, F. (2014): First epidemiological report of feline heartworm infection in the Barcelona metropolitan area (Spain). Parasite Vectors, 7: 506. DOI: 10.1186/s13071-014-0506-6 Montoya-Alonso J.A. Careton E. Garcia-Guasch L. Exposito J. Armario B. Morchon R. Simon F. 2014 First epidemiological report of feline heartworm infection in the Barcelona metropolitan area (Spain) Parasite Vectors 7 506 10.1186/s13071-014-0506-6423307625387458Open DOISearch in Google Scholar

Montoya-Alonso, J.A., Morchon, R., Falcon-Cordon, Y., Falcon-Cordon, S., Simon, F., Careton, E. (2017): Prevalence of heartworm in dogs and cats of Madrid, Spain. Parasite Vectors, 10(1): 354. DOI: 10.1186/s13071-017-2299-x Montoya-Alonso J.A. Morchon R. Falcon-Cordon Y. Falcon-Cordon S. Simon F. Careton E. 2017 Prevalence of heartworm in dogs and cats of Madrid, Spain Parasite Vectors 101 354 10.1186/s13071-017-2299-x553049528747221Open DOISearch in Google Scholar

Morchon, R., Careton, E., Gonzalez-Miguel, J., Mellado-Hernandez, I. (2012): Heartworm disease (Dirofilaria immitis) and their vectors in Europe – new distribution trends. Front. Physiol., 3: 196. DOI: 10.3389/fphys.2012.00196 Morchon R. Careton E. Gonzalez-Miguel J. Mellado-Hernandez I. 2012 Heartworm disease (Dirofilaria immitis) and their vectors in Europe – new distribution trends Front. Physiol 3 196 10.3389/fphys.2012.00196337294822701433Open DOISearch in Google Scholar

Nelson, C.T. (2008): Dirofilaria immitis in cats: diagnosis and management. Compend. Contin. Educ. Vet., 30(7): 393–400 Nelson C.T. 2008 Dirofilaria immitis in cats: diagnosis and management Compend. Contin. Educ. Vet 307 393 400Search in Google Scholar

Pana, D., Radulescu, A., Mitrea, I.L., Ionita, M. (2020): First report on clinical feline heartworm (Dirofilaria immitis) infection in Romania. Helminthologia, 57(1): 49–56. DOI: 10.2478/helm-2020-0009 Pennisi, M.G., Hartmann, K., Addie, D.D., Boucraut-Baralon, C., Egberink, H., Frymus, T., Gruffyd-Jones, T., Horzinek, M.C., Hosie, M.J., Lloret, A., Lutz, H., Marsilio, F., Radford, A.D., Thiry, E., Truyen, U., Mostl, K. (2015): Lungworm disease in cats: ABCD guidelines on prevention and management. J. Feline Med. Surg., 17(7): 626–636. DOI: 10.1177/1098612X15588455 Pana D. Radulescu A. Mitrea I.L. Ionita M. 2020 First report on clinical feline heartworm (Dirofilaria immitis) infection in Romania Helminthologia 571 49 56 10.2478/helm-2020-0009 Pennisi, M.G., Hartmann, K., Addie, D.D., Boucraut-Baralon, C., Egberink, H., Frymus, T., Gruffyd-Jones, T., Horzinek, M.C., Hosie, M.J., Lloret, A., Lutz, H., Marsilio, F., Radford, A.D., Thiry, E., Truyen, U., Mostl, K. (2015): Lungworm disease in cats: ABCD guidelines on prevention and management. J. Feline Med. Surg., 17(7): 626–636 10.1177/1098612X15588455699625932063740Open DOISearch in Google Scholar

Pennisi, M.G., Tasker, S., Hartmann, K., Belak, S., Addie, D., Boucraut-Baralon, C., Egberink, H., Frymus, T., Hofmann-Lehmann, R., Hosie, M., Lloret, A., Marsilio, F., Thiry, E., Truyen, U., Mostl, K. (2020): Dirofilarioses in cats: European guidelines from the ABCD on prevention and management. J. Feline Med. Surg., 22(5): 442–451. DOI: 10.1177/1098612X20917601 Pennisi M.G. Tasker S. Hartmann K. Belak S. Addie D. Boucraut-Baralon C. Egberink H. Frymus T. Hofmann-Lehmann R. Hosie M. Lloret A. Marsilio F. Thiry E. Truyen U. Mostl K. 2020 Dirofilarioses in cats: European guidelines from the ABCD on prevention and management J. Feline Med. Surg 225 442 451 10.1177/1098612X2091760132326862Open DOISearch in Google Scholar

Pereira, B.B., Bastos, B.F., Keidel, L., Leles, D., Brener, B. (2018): Feline heartworm (Dirofilaria immitis) infection: first case report of serological diagnosis in Brazil, confirmed by molecular assay. An. Acad. Bras. Cienc., 90(2): 2293–2297. DOI: 10.1590/00013765201820170063 Pereira B.B. Bastos B.F. Keidel L. Leles D. Brener B. 2018 Feline heartworm (Dirofilaria immitis) infection: first case report of serological diagnosis in Brazil, confirmed by molecular assay An. Acad. Bras. Cienc 902 2293 2297 10.1590/00013765201820170063Open DOISearch in Google Scholar

Schnyder, M., Di Cesare, A., Basso, W., Guscetti, F., Riond, B., Glaus, T., Crisi, P., Deplazes, P. (2014): Clinical, laboratory and pathological findings in cats experimentally infected with Aelurostrongylus abstrusus Parasitol. Res., 113: 1425–1433. DOI: 10.1007/s00436-014-3783-2 Schnyder M. Di Cesare A. Basso W. Guscetti F. Riond B. Glaus T. Crisi P. Deplazes P. 2014 Clinical, laboratory and pathological findings in cats experimentally infected with Aelurostrongylus abstrusus Parasitol. Res 113 1425 1433 10.1007/s00436-014-3783-224504600Open DOISearch in Google Scholar

Snyder, P., Levy, J., Salute, M.E., Gorman, S.P., Kubilis, P.S., Smail, P.W., George, L.L. (2000): Performance of serologic tests used to detect heartworm infection in cats. J. Am. Vet. Med. Assoc., 216(5): 693–700. DOI: 10.2460/javma.2000.216.693 Snyder P. Levy J. Salute M.E. Gorman S.P. Kubilis P.S. Smail P.W. George L.L. 2000 Performance of serologic tests used to detect heartworm infection in cats J. Am. Vet. Med. Assoc 2165 693 700 10.2460/javma.2000.216.69310707684Open DOISearch in Google Scholar

Traversa, D., Di Cesare, A. (2014): Cardio-pulmonary parasitic nematodes affecting cats in Europe: unraveling the past, depicting the present, and predicting the future. Front. Vet. Sci., 1: 11. DOI: 10.3389/fvets.2014.00011 Traversa D. Di Cesare A. 2014 Cardio-pulmonary parasitic nematodes affecting cats in Europe: unraveling the past, depicting the present, and predicting the future Front. Vet. Sci 1 11 10.3389/fvets.2014.00011466885326664917Open DOISearch in Google Scholar

Venco, L., Genchi, C., Genchi, M., Grandi, G., Kramer, L. H. (2008): Clinical evolution and radiographic findings of feline heartworm infection in asymptomatic cats. Vet. Parasitol., 158(3): 232–237. DOI: 10.1016/j.vetpar.2008.09.011 Venco L. Genchi C. Genchi M. Grandi G. Kramer L. H. 2008 Clinical evolution and radiographic findings of feline heartworm infection in asymptomatic cats Vet. Parasitol 1583 232 237 10.1016/j.vetpar.2008.09.01118952375Open DOISearch in Google Scholar

Venco, L., Marchesotti, F., Manzochi, S. (2015): Feline heart-worm disease: a ‘Rubik’s-cube-like’ diagnostic and therapeutic challenge. J. Vet. Cardiol., 17(1): 190–201. DOI: 10.1016/j.jvc.2015.08.004 Venco L. Marchesotti F. Manzochi S. 2015 Feline heart-worm disease: a ‘Rubik’s-cube-like’ diagnostic and therapeutic challenge J. Vet. Cardiol 171 190 201 10.1016/j.jvc.2015.08.00426776577Open DOISearch in Google Scholar

Zajac, A., Conboy, G. (2012): Veterinary Clinical Parasitology. 8^th Edition, Chichester, UK, Wiley-Blackwell, pp. 14–87 Zajac A. Conboy G. 2012 Veterinary Clinical Parasitology. 8^th Edition Chichester, UK, Wiley-Blackwell pp 14 87Search in Google Scholar