<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Parasitic helminthes can suppress and/or regulate the host immune response to allow long-term survival and chronic infection where toll-like receptors (TLRs) expressed on macrophages play essential roles in response to parasitic infection. Semi-quantitative PCR and flow cytometry studies about the modulation of TLRs and cytokine profiles in macrophages following <italic>T. spiralis</italic> infection were performed. TLRs, MyD88 and NF-κB were up-regulated by <italic>T. spiralis</italic> infection and essential to the parasite life cycles. Cytokines profiles (IL-6, IL-10, IL-12, TNF-α) were modulated during <italic>T. spiralis</italic> infection. Results suggest that <italic>T. spiralis</italic> infection may regulate the expression of TLR4 on macrophages and TLR4/MyD88/NF-κB signaling pathways. This study provides further insights into the mechanisms of TLR-mediated post-inflammatory response during <italic>T. spiralis</italic> infection.</p></abstract>

Parasitic helminthes can suppress and/or regulate the host immune response to allow long-term survival and chronic infection where toll-like receptors (TLRs) expressed on macrophages play essential roles in response to parasitic infection. Semi-quantitative PCR and flow cytometry studies about the modulation of TLRs and cytokine profiles in macrophages following T. spiralis infection were performed. TLRs, MyD88 and NF-κB were up-regulated by T. spiralis infection and essential to the parasite life cycles. Cytokines profiles (IL-6, IL-10, IL-12, TNF-α) were modulated during T. spiralis infection. Results suggest that T. spiralis infection may regulate the expression of TLR4 on macrophages and TLR4/MyD88/NF-κB signaling pathways. This study provides further insights into the mechanisms of TLR-mediated post-inflammatory response during T. spiralis infection.

Modulation of TLR2 and TLR4 in macrophages following <italic>Trichinella spiralis</italic> infection

Tiemaike Animal Husbandry and Veterinary station

Helminthologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Modulation of TLR2 and TLR4 in macrophages following  infection

Parasitic helminthes can suppress and/or regulate the host immune response to allow long-term survival and chronic infection where toll-like receptors (TLRs)...

Modulation of TLR2 and TLR4 in macrophages following Trichinella spiralis infection

Published Online: Jul 28, 2018

Page range: 195 - 203

Received: Apr 06, 2017

Accepted: Feb 20, 2018

DOI: https://doi.org/10.2478/helm-2018-0015

Keywords
Toll-like receptor, Helminth, Immune modulation

© 2018 C. Han et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Modulation of TLR2 and TLR4 in macrophages following Trichinella spiralis infection

Published Online: Jul 28, 2018

Page range: 195 - 203

Received: Apr 06, 2017

Accepted: Feb 20, 2018

DOI: https://doi.org/10.2478/helm-2018-0015

KeywordsToll-like receptor, Helminth, Immune modulation

© 2018 C. Han et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Toll-like receptor, Helminth, Immune modulation