<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_gp-2019-0015_s_013_w2aab3b8c11b1b7b1aab1c14b1Aa"><h3>Objectives</h3><p>Guarana (Paullinia cupana) from the Sapindaceae family, native to the Amazon basin, is a natural stimulant herb that can be found in popular energy drinks, pharmaceutical shops or local herb shops. With the use of natural health products increasing, guarana has gained a fair amount of popularity in the past years. In this systematic review, we examined the effects of guarana supplementation on cognitive performance. A secondary objective was to compare guarana with caffeine on cognitive performance.</p></sec><sec id="j_gp-2019-0015_s_015_w2aab3b8c11b1b7b1aab1c14b2Aa"><h3>Methods</h3><p>Searches were made in PubMed using the terms ‘Guarana’ or ‘Paullinia cupana’. Filters focused on Controlled Clinical trials. Inclusion criteria were met by studies using interventions with guarana, while focusing on guarana’s effects on cognition. Participants needed to be young, healthy adults. Studies not published in English or Greek were excluded. The last date of our search was March 7, 2019.</p></sec><sec id="j_gp-2019-0015_s_016_w2aab3b8c11b1b7b1aab1c14b3Aa"><h3>Results</h3><p>A total of 29 studies were identified and screened. After screening, 17 studies were excluded. The remaining 12 studies were found eligible for data extraction. After reading the full text of the 12 studies, 3 studies were excluded. In the end, 9 studies were found eligible for our systematic review (n = 369 participants). In these studies, guarana showed to improve reaction time and accuracy of performance at cognitive tasks. No significant differences were found when comparing guarana with caffeine.</p></sec><sec id="j_gp-2019-0015_s_017_w2aab3b8c11b1b7b1aab1c14b4Aa"><h3>Conclusion</h3><p>Guarana seems to improve reaction time and accuracy of performance at tasks, but no significant effects were found when compared with caffeine. High quality randomized controlled clinical trials with a low risk of bias are needed to further study the herb.</p></sec></abstract>

ObjectivesGuarana (Paullinia cupana) from the Sapindaceae family, native to the Amazon basin, is a natural stimulant herb that can be found in popular energy drinks, pharmaceutical shops or local herb shops. With the use of natural health products increasing, guarana has gained a fair amount of popularity in the past years. In this systematic review, we examined the effects of guarana supplementation on cognitive performance. A secondary objective was to compare guarana with caffeine on cognitive performance.MethodsSearches were made in PubMed using the terms ‘Guarana’ or ‘Paullinia cupana’. Filters focused on Controlled Clinical trials. Inclusion criteria were met by studies using interventions with guarana, while focusing on guarana’s effects on cognition. Participants needed to be young, healthy adults. Studies not published in English or Greek were excluded. The last date of our search was March 7, 2019.ResultsA total of 29 studies were identified and screened. After screening, 17 studies were excluded. The remaining 12 studies were found eligible for data extraction. After reading the full text of the 12 studies, 3 studies were excluded. In the end, 9 studies were found eligible for our systematic review (n = 369 participants). In these studies, guarana showed to improve reaction time and accuracy of performance at cognitive tasks. No significant differences were found when comparing guarana with caffeine.ConclusionGuarana seems to improve reaction time and accuracy of performance at tasks, but no significant effects were found when compared with caffeine. High quality randomized controlled clinical trials with a low risk of bias are needed to further study the herb.

The effects of Guarana (Paullinia cupana) supplementation on the cognitive performance of young healthy adults – a Systematic Review

Global Psychiatry

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

ObjectivesGuarana (Paullinia cupana) from the Sapindaceae family, native to the Amazon basin, is a natural stimulant herb that can be found in popular energy...

The effects of Guarana (Paullinia cupana) supplementation on the cognitive performance of young healthy adults – a Systematic Review

Published Online: Sep 13, 2019

Page range: 171 - 182

Received: Apr 17, 2019

Accepted: Jul 17, 2019

DOI: https://doi.org/10.2478/gp-2019-0015

Keywords
Guarana, Paullinia Cupana, Caffeine, Cognition, Nootropics, Herbal Medicine, Systematic Review

© 2019 Fanaras Konstantinos, Dr. Reinhard Heun, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The effects of Guarana (Paullinia cupana) supplementation on the cognitive performance of young healthy adults – a Systematic Review

Published Online: Sep 13, 2019

Page range: 171 - 182

Received: Apr 17, 2019

Accepted: Jul 17, 2019

DOI: https://doi.org/10.2478/gp-2019-0015

KeywordsGuarana, Paullinia Cupana, Caffeine, Cognition, Nootropics, Herbal Medicine, Systematic Review

© 2019 Fanaras Konstantinos, Dr. Reinhard Heun, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Guarana, Paullinia Cupana, Caffeine, Cognition, Nootropics, Herbal Medicine, Systematic Review