<abstract xmlns="http://www.w3.org/1999/xhtml"><p><italic>Neisseria meningitidis</italic> is a Gram-negative diplococcus responsible for bacterial meningitis and fatal sepsis. Ligand-receptor interactions are one of the main steps in the development of neuroinvasion. Porin B (PorB), neisserial outer membrane protein (ligand), binds to host receptors and triggers many cell signalling cascades allowing the meningococcus to damage the host cells or induce immune cells responses via the TLR2-dependent mechanisms. In this paper, we present a brief review of the structure and function of PorB.</p></abstract>

Neisseria meningitidis is a Gram-negative diplococcus responsible for bacterial meningitis and fatal sepsis. Ligand-receptor interactions are one of the main steps in the development of neuroinvasion. Porin B (PorB), neisserial outer membrane protein (ligand), binds to host receptors and triggers many cell signalling cascades allowing the meningococcus to damage the host cells or induce immune cells responses via the TLR2-dependent mechanisms. In this paper, we present a brief review of the structure and function of PorB.

The Role of Meningococcal Porin B in Protein-Protein Interactions with Host Cells

Laboratory of Biomedical Microbiology and Immunology

University of Veterinary Medicine and Pharmacy

Institute of Neuroimmunology, Slovak Academy of Sciences

Folia Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Neisseria meningitidis is a Gram-negative diplococcus responsible for bacterial meningitis and fatal sepsis. Ligand-receptor interactions are one of the main...

The Role of Meningococcal Porin B in Protein-Protein Interactions with Host Cells

Published Online: Apr 11, 2018

Page range: 52 - 58

Received: Dec 04, 2017

Accepted: Jan 26, 2018

DOI: https://doi.org/10.2478/fv-2018-0008

Keywords
PorB, protein, Toll-like receptor

© 2018 Káňová, E. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The Role of Meningococcal Porin B in Protein-Protein Interactions with Host Cells

Published Online: Apr 11, 2018

Page range: 52 - 58

Received: Dec 04, 2017

Accepted: Jan 26, 2018

DOI: https://doi.org/10.2478/fv-2018-0008

KeywordsPorB, protein, Toll-like receptor

© 2018 Káňová, E. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
PorB, protein, Toll-like receptor