Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells

Arabanian LS, Johansson P, Staffas A, Nilsson T, Rouhi A, Fogelstrand L, Palmqvist L. The endothelin receptor type A is a downstream target of Hoxa9 and Meis1 in acute myeloid leukemia. Leuk Res 75, 61–68, 2018.10.1016/j.leukres.2018.10.005Search in Google Scholar

Auf G, Jabouille A, Guerit S, Pineau R, Delugin M, Bouchecareilh M, Favereaux A, Maitre M, Gaiser T, von Deimling A, Czabanka M, Vajkoczy P, Chevet E, Bikfalvi A, Moenner M. A shift from an angiogenic to invasive phenotype induced in malignant glioma by inhibition of the unfolded protein response sensor IRE1. Proc Natl Acad Sci U S A 107, 15553–15558, 2010.10.1073/pnas.0914072107Search in Google Scholar

Auf G, Jabouille A, Delugin M, Guerit S, Pineau R, North S, Platonova N, Maitre M, Favereaux A, Vajkoczy P, Seno M, Bikfalvi A, Minchenko D, Minchenko O, Moenner M. High epiregulin expression in human U87 glioma cells relies on IRE1alpha and promotes autocrine growth through EGF receptor. BMC Cancer 13, 597, 2013.10.1186/1471-2407-13-597Search in Google Scholar

Aydin AF, Vural P, Dogru-Abbasoglu S, Cil E. The endothelin 1 and endothelin receptor A gene polymorphisms increase the risk of developing papillary thyroid cancer. Mol Biol Rep 46, 199–205, 2019.10.1007/s11033-018-4461-8Search in Google Scholar

Aversa CR, Oparil S, Caro J, Li H, Sun S-D, Chen Y-F, Swerdel MR, Monticello TM, Durham SK, Minchenko A, Lira SA, Webb ML. Hypoxia stimulates human preproendothelin-1 promoter activity in transgenic mice. Amer J Physiol 273, L848–L855, 1997.10.1152/ajplung.1997.273.4.L848Search in Google Scholar

Bao N, Fang B, Lv H, Jiang Y, Chen F, Wang Z, Ma H. Upregulation of miR-199a-5p protects spinal cord against ischemia/reperfusion-induced injury via downregulation of ECE1 in rat. Cell Mol Neurobiol 38, 1293–1303, 2018.10.1007/s10571-018-0597-2Search in Google Scholar

Boratko A, Vereb Z, Petrovski G, Csortos C. TIMAP-protein phosphatase 1-complex controls endothelin-1 production via ECE-1 dephosphorylation. Int J Biochem Cell Biol 73, 11–18, 2016.10.1016/j.biocel.2016.01.016Search in Google Scholar

Bravo R, Parra V, Gatica D, Rodriguez AE, Torrealba N, Paredes F, Wang ZV, Zorzano A, Hill JA, Jaimovich E, Quest AF, Lavandero S. Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol 301, 215–290, 2013.10.1016/B978-0-12-407704-1.00005-1Search in Google Scholar

Chesney J, Clark J, Klarer AC, Imbert-Fernandez Y, Lane AN, Telang S. Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. Oncotarget 5, 6670–6686, 2014.2511539810.18632/oncotarget.2213Search in Google Scholar

Chevet E, Hetz C, Samali A. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov 5, 586–597, 2015.10.1158/2159-8290.CD-14-1490Search in Google Scholar

Chua FY, Adams BD. Androgen receptor and miR-206 regulation in prostate cancer. Transcription 8, 313–327, 2017.10.1080/21541264.2017.1322668Search in Google Scholar

Cook N, Brais R, Qian W, Hak CC, Corrie PG. Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma. J Clin Pathol 68, 309–313, 2015.10.1136/jclinpath-2014-202521Search in Google Scholar

Dashwood MR, Loesch A. Endothelin-1 as a neuropeptide: neurotransmitter or neurovascular effects? J Cell Commun Signal 4, 51–62, 2009.10.1007/s12079-009-0073-3Search in Google Scholar

Dojo Soeandy C, Salmasi F, Latif M, Elia AJ, Suo NJ, Henderson JT. Endothelin-1-mediated cerebral ischemia in mice: early cellular events and the role of caspase-3. Apoptosis 24, 578–595, 2019.10.1007/s10495-019-01541-zSearch in Google Scholar

Doultsinos D, Avril T, Lhomond S, Dejeans N, Guedat P, Chevet E. Control of the unfolded protein response in health and disease. SLAS Discov 22, 787–800, 2017.2845337610.1177/2472555217701685Search in Google Scholar

Drogat B, Auguste P, Nguyen DT, Bouchecareilh M, Pineau R, Nalbantoglu J, Kaufman RJ, Chevet E, Bikfalvi A, Moenner M. IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. Cancer Res 67, 6700–6707, 2007.10.1158/0008-5472.CAN-06-3235Search in Google Scholar

Farhat FP, Martins CB, De Lima LH, Isoldi MC, Castrucci AM. Melanopsin and clock genes: regulation by light and endothelin in the zebrafish ZEM-2S cell line. Chronobiol Int 26, 1090–1119, 2009.10.3109/07420520903249005Open DOISearch in Google Scholar

Fomin V, Richard P, Hoque M, Li C, Gu Z, Fissore-O’Leary M, Tian B, Prives C, Manley JL. The C9ORF72 gene, implicated in amyotrophic lateral sclerosis and frontotemporal dementia, encodes a protein that functions in control of endothelin and glutamate signaling. Mol Cell Biol 38, e00155–18, 2018.10.1128/MCB.00155-18Search in Google Scholar

Franzen S, Pihl L, Fasching A, Palm F. Intrarenal activation of endothelin type B receptors improves kidney oxygenation in type 1 diabetic rats. Am J Physiol Renal Physiol 314, F439–F444, 2018.10.1152/ajprenal.00498.2017Search in Google Scholar

Iurlaro R, Puschel F, Leon-Annicchiarico CL, O’Connor H, Martin SJ, Palou-Gramon D, Lucendo E, Munoz-Pinedo C. Glucose deprivation induces ATF4-mediated apoptosis through TRAIL death receptors. Mol Cell Biol 37, e00479–16, 2017.10.1128/MCB.00479-16Search in Google Scholar

Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, Meidan R, Koesters R, Rosen S, Walkinshaw G, Mimura I, Nangaku M, Heyman SN. Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor. Kidney Int 87, 761–770, 2015.10.1038/ki.2014.362Search in Google Scholar

Khimji AK, Rockey DC. Endothelin—biology and disease. Cell Signal 22, 1615–1625, 2010.10.1016/j.cellsig.2010.05.002Open DOISearch in Google Scholar

Liang Z, Li Y, Huang K, Wagar N, Shim H. Regulation of miR-19 to breast cancer chemoresistance through targeting PTEN. Pharm Res 28, 3091–3100, 2011.10.1007/s11095-011-0570-yOpen DOISearch in Google Scholar

Lin H, Dai T, Xiong H, Zhao X, Chen X, Yu C, Li J, Wang X, Song L. Unregulated miR-96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a. PLoS One 5, e15797, 2010.10.1371/journal.pone.0015797Search in Google Scholar

Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jager R, Gorman AM, Samali A. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun 9, 3267, 2018.10.1038/s41467-018-05763-8Search in Google Scholar

Manie SN, Lebeau J, Chevet E. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update. Am J Physiol Cell Physiol 307, C901–C907, 2014.10.1152/ajpcell.00292.2014Search in Google Scholar

McMahon M, Samali A, Chevet E. Regulation of the unfolded protein response by noncoding RNA. Am J Physiol Cell Physiol 313, C243–C254, 2017.10.1152/ajpcell.00293.2016Search in Google Scholar

Minchenko AG, Armstead VE, Opentanova IL, Lefer AM. Endothelin-1, endothelin receptors and ecNOS gene expression in vital organs during traumatic shock in rats. Endothelium 6, 303–314, 1999.10.3109/10623329909078497Search in Google Scholar

Minchenko A, Caro J. Regulation of endothelin-1 gene expression in human microvascular endothelial cells by hypoxia and cobalt: role of hypoxia responsible element. Mol Cell Biochem 208, 53–62, 2000.10.1023/A:1007042729486Search in Google Scholar

Minchenko AG, Stevens MJ, White L, Abatan OI, Komjati K, Pacher P, Szabo C, Obrosova IG. Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose)polymerase activation. FASEB J 17, 1514–1516, 2003.10.1096/fj.03-0013fjeSearch in Google Scholar

Minchenko OH, Kharkova AP, Bakalets TV, Kryvdiuk IV. Endoplasmic reticulum stress, its sensor and signaling systems and the role in regulation of gene expressions at malignant tumor growth and hypoxia. Ukr Biokhim Zh 85, 5–16, 2013.10.15407/ubj85.05.005Search in Google Scholar

Minchenko DO, Danilovskyi SV, Kryvdiuk IV, Bakalets TV, Lypova NM, Karbovskyi LL, Minchenko OH. Inhibition of ERN1 modifies the hypoxic regulation of the expression of TP53-related genes in U87 glioma cells. Endoplasm Reticul Stress Dis 1, 18–26, 2014.10.2478/ersc-2014-0001Search in Google Scholar

Minchenko DO, Kharkova AP, Tsymbal DO, Karbovskyi LL, Minchenko OH. Expression of insulin-like growth factor binding protein genes and its hypoxic regulation in U87 glioma cells depends on ERN1 mediated signaling pathway of endoplasmic reticulum stress. Endocr Regul 49, 73–83, 2015a.10.4149/endo_2015_02_73Search in Google Scholar

Minchenko OH, Tsymbal DO, Minchenko DO, Kovalevska OV, Karbovskyi LL, Bikfalvi A. Inhibition of ERN1 signaling enzyme affects hypoxic regulation of the expression of E2F8, EPAS1, HOXC6, ATF3, TBX3 and FOXF1 genes in U87 glioma cells. Ukr Biochem J 87, 76–87, 2015b.10.15407/ubj87.02.076Search in Google Scholar

Minchenko OH, Tsymbal DO, Minchenko DO, Moenner M, Kovalevska OV, Lypova NM. Inhibition of kinase and endoribonuclease activity of ERN1/IRE1 affects expression of proliferation-related genes in U87 glioma cells. Endoplasm Reticul Stress Dis 2, 18–29, 2015c.10.1515/ersc-2015-0002Search in Google Scholar

Minchenko OH, Kryvdiuk IV, Minchenko DO, Riabovol OO, Halkin OV. Inhibition of IRE1 signaling affects expression of a subset genes encoding for TNF-related factors and receptors and modifies their hypoxic regulation in U87 glioma cells. Endoplasm Reticul Stress Dis 3, 1–15, 2016.10.1515/ersc-2016-0001Search in Google Scholar

Minchenko OH, Luzina OY, Hnatiuk OS, Minchenko DO, Garmash YA, Ratushna OO. Expression of tumor growth related genes in IRE1 knockdown U87 glioma cells: effect of hypoxia. Ukr Biochem J 89, 40–51, 2017.10.15407/ubj89.05.040Search in Google Scholar

Minchenko DO, Tsymbal DO, Davydov VV, Minchenko OH. Expression of genes encoding IGF1, IGF2, and IGFBPs in blood of obese adolescents with insulin resistance. Endocr Reg 53, 34–45, 2019.10.2478/enr-2019-0005Search in Google Scholar

Miners JS, Love S. Endothelin-converting enzymes degrade alpha-synuclein and are reduced in dementia with Lewy bodies. J Neurochem 141, 275–286, 2017.10.1111/jnc.13974Search in Google Scholar

Nayak L, Reardon DA. High-grade gliomas. Continuum (Minneap Minn) 23, 1548–1563, 2017.10.1212/CON.0000000000000554Search in Google Scholar

Niechi I, Silva E, Cabello P, Huerta H, Carrasco V, Villar P, Cataldo LR, Marcelain K, Armisen R, Varas-Godoy M, Fernandez C, Tapia JC. Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability. Oncotarget 6, 42749–42760, 2015.10.18632/oncotarget.5722Search in Google Scholar

Palmer JC, Barker R, Kehoe PG, Love S. Endothelin-1 is elevated in Alzheimer’s disease and upregulated by amyloid-β. J Alzheimers Dis 29, 853–861, 2012.10.3233/JAD-2012-111760Search in Google Scholar

Papaioannou A, Chevet E. Driving cancer tumorigenesis and metastasis through UPR signaling. Curr Top Microbiol Immunol 414, 159–192, 2018.10.1007/82_2017_36Search in Google Scholar

Russignan A, Spina C, Tamassia N, Cassaro A, Rigo A, Bagnato A, Rosano L, Bonalumi A, Gottardi M, Zanatta L, Giacomazzi A, Scupoli MT, Tinelli M, Salvadori U, Mosna F, Zamo A, Cassatella MA, Vinante F, Tecchio C. Endothelin-1 receptor blockade as new possible therapeutic approach in multiple myeloma. Br J Haematol 178, 781–793, 2017.10.1111/bjh.14771Search in Google Scholar

Semenza GL. A compendium of proteins that interact with HIF-1α. Exp Cell Res 356, 128–135, 2017.10.1016/j.yexcr.2017.03.041Search in Google Scholar

Singh A, Happel C, Manna SK, Acquaah-Mensah G, Carrerero J, Kumar S, Nasipuri P, Krausz KW, Wakabayashi N, Dewi R, Boros LG, Gonzalez FJ, Gabrielson E, Wong KK, Girnun G, Biswal S. Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. J Clin Invest 123, 2921–2934, 2013.10.1172/JCI66353Search in Google Scholar

Stobdan T, Zhou D, Williams AT, Cabrales P, Haddad GG. Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia. J Mol Med (Berl) 96, 975–982, 2018.3006974510.1007/s00109-018-1673-2Search in Google Scholar

Stow LR, Jacobs ME, Wingo CS, Cain BD. Endothelin-1 gene regulation. FASEB J 25, 16–28, 2011.10.1096/fj.10-161612Search in Google Scholar

Sun RC, Denko NC. Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metab 19, 285–292, 2014.10.1016/j.cmet.2013.11.02224506869Open DOISearch in Google Scholar

Tapia JC, Niechi I. Endothelin-converting enzyme-1 in cancer aggressiveness. Cancer Lett 452, 152–157, 2019.10.1016/j.canlet.2019.03.033Search in Google Scholar

Teramoto K, Katoh H. The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions. Cell Signal 62, 109329, 2019.10.1016/j.cellsig.2019.05.014Search in Google Scholar

Teoh JP, Park KM, Wang Y, Hu Q, Kim S, Wu G, Huang S, Maihle N, Kim IM. Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis. Cell Signal 26, 2885–2895, 2014.10.1016/j.cellsig.2014.08.024Search in Google Scholar

Tsymbal DO, Minchenko DO, Hnatiuk OS, Luzina OY, Minchenko OH. Effect of hypoxia on the expression of a subset of proliferation related genes in IRE1 knockdown U87 glioma cells. Adv Biol Chem 7, 195–210, 2017.10.4236/abc.2017.76014Search in Google Scholar

Womeldorff M, Gillespie D, Jensen RL. Hypoxia-inducible factor–1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastoma. Neurosurg Focus 37, E8, 2014.10.3171/2014.9.FOCUS14496Search in Google Scholar

Yalcin A, Clem BF, Imbert-Fernandez Y, Ozcan SC, Peker S, O’Neal J, Klarer AC, Clem AL, Telang S, Chesney J. 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. Cell Death Dis 5, e1337, 2014.10.1038/cddis.2014.292Search in Google Scholar

Yang L, Lin C, Wang L, Guo H, Wang X. Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications. Exp Cell Res 318, 2417–2426, 2012.10.1016/j.yexcr.2012.07.017Search in Google Scholar

Zhang J, Zhao WS, Wang X, Xu L, Yang XC. Palmitic acid increases endothelin-1 expression in vascular endothelial cells through the induction of endoplasmic reticulum stress and protein kinase C signaling. Cardiology 140, 133–140, 2018.10.1159/000490093Open DOISearch in Google Scholar

Zhang L, Luo B, Dang YW, He RQ, Chen G, Peng ZG, Feng ZB. The clinical significance of endothelin receptor type B in hepatocellular carcinoma and its potential molecular mechanism. Exp Mol Pathol 107, 141–157, 2019.10.1016/j.yexmp.2019.02.002Search in Google Scholar

Zhao S, Cai J, Li J, Bao G, Li D, Li Y, Zhai X, Jiang C, Fan L. Bioinformatic profiling identifies a glucose-related risk signature for the malignancy of glioma and the survival of patients. Mol Neurobiol 54, 8203–8210, 2017.2790067910.1007/s12035-016-0314-4Search in Google Scholar