<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objectives.</bold> Diabetes mellitus is an endemic disease of the current era. It is important to treat it properly. All antidiabetic medications have side effects and various safety profiles.<bold>Case report.</bold> Fifty-two years old patient with type II diabetes mellitus, who had spontaneous cutaneous and intra muscular bleeding after starting treatment with Exenatide. The patient’s history did not include any kind of spontaneous bleeding. Investigations did not reveal abnormal platelets count and function or coagulation profile. The use of the Exenatide was discontinued and during one year of follow-up, the patient did not experience an additional occurrence of spontaneous bleeding.<bold>Conclusions.</bold> To the best of our knowledge, this is the first report of spontaneous bleeding probably caused by Exenatide. The exact pathophysiology, by which the drug can cause spontaneous bleeding, is still not clear and has to be revealed.</abstract>

Objectives. Diabetes mellitus is an endemic disease of the current era. It is important to treat it properly. All antidiabetic medications have side effects and various safety profiles.Case report. Fifty-two years old patient with type II diabetes mellitus, who had spontaneous cutaneous and intra muscular bleeding after starting treatment with Exenatide. The patient’s history did not include any kind of spontaneous bleeding. Investigations did not reveal abnormal platelets count and function or coagulation profile. The use of the Exenatide was discontinued and during one year of follow-up, the patient did not experience an additional occurrence of spontaneous bleeding.Conclusions. To the best of our knowledge, this is the first report of spontaneous bleeding probably caused by Exenatide. The exact pathophysiology, by which the drug can cause spontaneous bleeding, is still not clear and has to be revealed.

Unexpected bleeding after Exenatide treatment: a causative relationship or a coincidence?

Internal medicine department B, Rambam Health Care Campus

Bruce and Ruth Rappaport Faculty of Medicine

Endocrine Regulations

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objectives. Diabetes mellitus is an endemic disease of the current era. It is important to treat it properly. All antidiabetic medications have side effects...

Unexpected bleeding after Exenatide treatment: a causative relationship or a coincidence?

Published Online: Aug 09, 2018

Page range: 159 - 162

DOI: https://doi.org/10.2478/enr-2018-0020

Keywords
glucagon like peptide 1, Exenatide, bleeding, complications

© 2018 Johad Khoury et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Unexpected bleeding after Exenatide treatment: a causative relationship or a coincidence?

Published Online: Aug 09, 2018

Page range: 159 - 162

DOI: https://doi.org/10.2478/enr-2018-0020

Keywordsglucagon like peptide 1, Exenatide, bleeding, complications

© 2018 Johad Khoury et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
glucagon like peptide 1, Exenatide, bleeding, complications