Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats

Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409, 729-733, 2001.10.1038/35055575Search in Google Scholar

Accili D, Drago J, Lee EJ, Johnson MD, Cool MH, Salvatore P, Asico LD, Jose PA, Taylor SI, Westphal H. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet 12, 106-109, 1996.10.1038/ng0196-106Open DOISearch in Google Scholar

Barbagallo M, Gupta R, Dominguez LJ, Resnick LM. Cellular ionic alterations with aging: relation to hypertension and diabetes. J Am Soc Geriatrics 48, 1111-1116, 2000.10.1111/j.1532-5415.2000.tb04788.xOpen DOISearch in Google Scholar

Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo A, Paolisso G. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med 24, 39-52, 2003.10.1016/S0098-2997(02)00090-0Search in Google Scholar

Barbagallo M, Dominguez JL. Magnesium metabolism in type 2 diabetes, metabolic syndrome and insulin resistance. Arch Biochem Biophys 458, 40-47, 2007.10.1016/j.abb.2006.05.007Search in Google Scholar

Bergman M. Pathophysiology of prediabetes and treatment implications for the prevention of type 2 diabetes mellitus. Endocrine 43,504-513, 2013.10.1007/s12020-012-9830-9Open DOISearch in Google Scholar

Bruning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, Accili D, Goodyear LJ, Kahn CR. A muscle-specifi c insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 2, 559-569, 1998.10.1016/S1097-2765(00)80155-0Open DOISearch in Google Scholar

Chang L, Chiang SH, Saltiel AR. Insulin signaling and the regulation of glucose transport. Mol Med 10, 65-71, 2004.10.2119/2005-00029.Saltiel143136716307172Search in Google Scholar

Charron MJ, Katz EB, Olson AL. GLUT4 gene regulation and manipulation. J Bio Chem 274, 3253-3256, 1999.10.1074/jbc.274.6.32539920861Search in Google Scholar

Cohen P. Th e twentieth century struggle to decipher insulin signalling. Nat Rev Mol Cell Biol 7, 867-873, 2006.10.1038/nrm204317057754Open DOISearch in Google Scholar

de Baaij JHF, Hoenderop JGJ, Bindels RJM. Magnesium in man: implications for health and disease. Physiol Rev 95, 1-46, 2015.10.1152/physrev.00012.2014Search in Google Scholar

Dong JY, Xun P, He K, Qin LQ. Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies. Diabetes Care 34, 2116-2122, 2011.10.2337/dc11-0518Open DOISearch in Google Scholar

Ene AC, Nwankwo EA, Sambi LM. Alloxan-induced diabetes in arts and the eff ects of black caraway (Caramcarvi L.) oil on their body weight. J Phamacol Toxicol 3, 141-146, 2007.10.3923/jpt.2008.141.146Search in Google Scholar

Festa A, Williams K, D’Agostino R Jr, Wagenknecht LE, Haff ner SM. Th e natural course of beta-cell function in nondiabetic and diabetic individuals: Th e insulin resistance atherosclerosis study. Diabetes 55, 1114-1120, 2006.10.2337/diabetes.55.04.06.db05-1100Search in Google Scholar

Furtado LM, Somwar R, Sweeney G, Niu W, Klip A. Activation of the glucose transporter GLUT4 by insulin. Biochem. Cell Biol 80, 569-578, 2002.10.1139/o02-156Open DOISearch in Google Scholar

Garfinkel D, Garfi nkel L. Magnesium and regulation of carbohydrate metabolism at the molecular level. Magnesium 7, 249-261, 1988.Search in Google Scholar

Hasanain B, Mooradian AD. Antioxidant vitamins and their infl uence in diabetes mellitus. Curr Diab Rep 2, 448- 456, 2002.10.1007/s11892-002-0110-6Search in Google Scholar

Hruby A, Ngwa JS, Renstrom F, Wojczynski MK, Ganna A, Hallmans G. Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. J Nutr 143, 345-353, 2013.10.3945/jn.112.172049Search in Google Scholar

Humphries S, Kushner H, Falkner B. Low dietary magnesium is associated with insulin resistance in a sample of young, nondiabetic Black Americans. Am J Hypertens 12, 747-756, 1999.10.1016/S0895-7061(99)00041-2Open DOISearch in Google Scholar

Irondi EA, Oboh G, Akindahunsi AA. Antidiabetic eff ects of Mangifera indica Kernel Flour-supplemented diet in streptozotocin-induced type 2 diabetic in rats. Food Sci Nutr 4, 828-839, 2016.10.1002/fsn3.348509064627826432Open DOISearch in Google Scholar

Joshi RL, Lamothe B, Cordonnier N, Mesbah K, Monthioux E, Jami J, Bucchini D. Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. Embo J 15, 1542-1547, 1996.10.1002/j.1460-2075.1996.tb00498.xSearch in Google Scholar

Kisters K, Gremmler B, Kozianka J, Hausberg M. Magnesium defi ciency and diabetes mellitus. Clin Nephrol 65, 77-78, 2006.10.5414/CNP65077Search in Google Scholar

Kitamura T, Kahn CR, Accili D. Insulin receptor knockout mice. Annu Rev Physiol 65, 313-332, 2003.10.1146/annurev.physiol.65.092101.14254012471165Open DOISearch in Google Scholar

Kulkarni RN, Winnay JN, Daniels M, Bruning JC, Flier SN, Hanahan D, Kahn CR. Altered function of insulin receptor substrate-1-defi cient mouse islets and cultured beta-cell lines. J Clin Invest 104, R69-R75, 1999.10.1172/JCI833940988710606633Search in Google Scholar

Kumar G, Banu GS, Murugesan AG. Eff ect of Helicteres isora bark extracts on heart antioxidant status and lipid peroxidation in streptozotocin diabetic rats. J Appl Biomed 6, 89-95, 2008.10.32725/jab.2008.012Search in Google Scholar

Leto D, Saltiel AR. Regulation of glucose transport by insulin: traffi c control of GLUT4. Nat Rev Mol Cell Biol 13, 383-396, 2012.10.1038/nrm335122617471Open DOISearch in Google Scholar

Li B, Tan Y, Sun W, Fu Y, Miao L, Cai L. Th e role of zinc in the prevention of diabetic cardiomyopathy and nephropathy. Toxicol Mech Methods 23, 27-33, 2013.10.3109/15376516.2012.73527723039870Search in Google Scholar

Lima ML, Cruz T, Ro drigues LE. Serum and intracellular magnesium defi ciency in patients with metabolic syndrome- evidences for its relation to insulin resistance. Diabetes Res Clin Pract 83, 257-262, 2009.10.1016/j.diabres.2008.11.01919124169Open DOISearch in Google Scholar

Mahmoud AM, Ashour MB, Abdel-Moneim A, Ahmed OM. Hesperidin and naringin attenuate hyperglycemiamediated oxidative stress and proinfl ammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. J Diabetes Complications 26, 483-490, 2012.10.1016/j.jdiacomp.2012.06.00122809898Search in Google Scholar

Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol, 1724-1738, 2003.Search in Google Scholar

Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaire-Buys D, Novelli M, Ribes G. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 47, 224- 229, 1998.10.2337/diab.47.2.2249519717Open DOISearch in Google Scholar

Masiello P. Animal models of type 2 diabetes with reduced pancreatic beta-cell mass. Int J Biochem Cell Biol 38, 873-893, 2006.10.1016/j.biocel.2005.09.00716253543Open DOISearch in Google Scholar

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetalogia 28, 412-419, 1985.10.1007/BF00280883Search in Google Scholar

Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR. A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Diabetes 49, 2126-2134, 2000.10.2337/diabetes.49.12.2126Search in Google Scholar

Mills BJ, Lindeman RD, Lang CA. Magnesium defi ciency inhibits biosynthesis of blood glutathione and tumor growth in the rat. Proc Soc Exp Biol Med 181, 326-332, 1986.10.3181/00379727-181-42260Search in Google Scholar

Mooren FC, Kruger K, Volker K, Golf SW, Wadepuhl M, Kraus A. Oral magnesium supplementation reduces insulin resistance in non-diabetic supplementation reduces insulin resistance in non-diabetic subjects - a doubleblind, placebo-controlled, randomized trial. Diabet Obes Metab 13, 281-284, 2011.10.1111/j.1463-1326.2010.01332.xSearch in Google Scholar

Moraes-Vieira PM, Saghatelian A, Kahn BB. GLUT4 expression in adipocytes regulates de novo lipogenesis and levels of a novel class of lipids with antidiabetic and anti-infl ammatory eff ects. Diabetes 65, 1808-1815, 2016.10.2337/db16-0221Open DOISearch in Google Scholar

Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman R, Rude R. Magnesium defi ciency produces insulin resistance and increased thromboxane synthesis. Hypertension 21, 1024-1029, 1993.10.1161/01.HYP.21.6.1024Open DOISearch in Google Scholar

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals. 8th edition. Washington (DC): National Academies Press (US); 2011.Search in Google Scholar

Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes: studies with a selective inhibitor wortmannin. J Biol Chem 269, 3568-3573, 1994.10.1016/S0021-9258(17)41901-6Search in Google Scholar

Okuno S, Akazawa S, Yasuhi I, Kawasaki E, Matsumoto K, Yamasaki H, Matsuo H, Yamaguchi Y, Nagataki S. Decreased expression of the GLUT4 glucose transporter protein in adipose-tissue during pregnancy. Horm Metab Res 27, 231-234, 1995.10.1055/s-2007-9799467642174Open DOISearch in Google Scholar

Paolisso G, Scheen, A, D’Onofrio F, Lefebvre P. Magnesium and glucose homeostasis. Diabetologia 33, 511-514, 1990.10.1007/BF004041362253826Open DOISearch in Google Scholar

Rude RK. “Magnesium” in Modern Nutrition in Health and Disease, Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, Eds., pp. 159-175, Lippincott Williams & Wilkins, Baltimore, Md., USA, 11th edition, 2012.Search in Google Scholar

Soltani N, Keshavarz M, Sohanaki H, Dehpour AR, Zahedi AS. Oral magnesium administration prevents vascular complications in STZ-diabetic rats. Life Sci 76, 1455-1464, 2005a.10.1016/j.lfs.2004.07.02715680310Open DOISearch in Google Scholar

Soltani N, Keshavarz M, Sohanaki H, Zahedi AS, Dehpour AR. Relaxatory eff ect of magnesium on mesenteric vascular beds diff ers from normal and streptozotocin induced diabetic rats. Eur J Pharmacol 508, 177-181, 2005b.10.1016/j.ejphar.2004.12.003Search in Google Scholar

Soltani N, Keshavarz M, Minaii B, Mirershadi F, Zahedi AS, Dehpour AR. Eff ect of administration of oral magnesium on plasma glucose and pathological changes in the aorta and pancreas of diabetic rats. Clin Exp Pharmacol Physiol 32, 604-610, 2005c.10.1111/j.0305-1870.2005.04238.xOpen DOISearch in Google Scholar

Soltani N, Keshavarz M, Dehpour AR. Eff ect of oral magnesium sulfate administration on blood pressure and lipid profi le in Streptozotocin diabetic rat. Eur J Pharmacol 560, 201-205, 2007.10.1016/j.ejphar.2006.12.020Search in Google Scholar

Soltani N, Qiu H, Aleksic M, Glinka Y, Zhao F, Liu R. GABA exerts protective and regenerative eff ects on islet beta cells and reverses diabetes. Proc Natl Acad Sci 108, 11692-11697, 2011.10.1073/pnas.1102715108Search in Google Scholar

Song Y, He K, Levitan EB, Manson JE, Liu S. Eff ects of oral magnesium supplementation on glycaemic control in type 2 diabetes: a meta-analysis of randomized double-blind controlled trials. Diabet Med 23, 1050-1056, 2006.10.1111/j.1464-5491.2006.01852.xSearch in Google Scholar

Tahara A, Matsuyama-Yokono A, Nakano R, Someya Y, Shibasaki M. Hypoglycaemic eff ects of anti-diabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic rats. Basic Clin Pharmacol Toxicol 103, 560-568, 2008.10.1111/j.1742-7843.2008.00321.xSearch in Google Scholar

Taheri Rouhi SZ, Sarker MMR, Rahmat A, Alkahtani SA, Othman F. Th e eff ect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profi le, infl ammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague-Dawley rats. BMC Complement Altern Med 17, 156, 2017.10.1186/s12906-017-1667-6Open DOISearch in Google Scholar

Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and insulin resistance. Magnes Res 17, 126-136, 2004.Search in Google Scholar

Tangvarasittichai S. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World J Diabetes 6, 456-480, 2015.10.4239/wjd.v6.i3.456Search in Google Scholar

Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86, 271-278, 1978.10.1016/0003-2697(78)90342-1Open DOISearch in Google Scholar

van Dooran DR, Liejdekker CM, Handerson PT. Synergistic eff ects of phorone on the hepatotoxicity of bromobenzene and paracetamol in mice. Toxicol 11, 225-233, 1978.10.1016/S0300-483X(78)91389-6Search in Google Scholar

Vasconcelos EM, Degasperi GR, de Oliveira HC, Vercesi AE, de Faria EC, Castilho LN. Reactive oxygen species generation in peripheral blood monocytes and oxidized LDL are increased in hyperlipidemic patients. Clin Biochem 42, 1222-1227, 2009.10.1016/j.clinbiochem.2009.05.010Open DOISearch in Google Scholar

Vicario PP, Bennun A. Separate eff ects of Mg2+, MgATP, and ATP4- on the kinetic mechanism for insulin receptor tyrosine kinase. Arch Biochem Biophys 278, 99-105, 1990.10.1016/0003-9861(90)90236-RSearch in Google Scholar

Vinals F, Camps M, Testar X, Palacin M, Zorzano A. Eff ect of cations on the tyrosine kinase activity of the insulin receptor: inhibition by fl uoride is magnesium dependent. Mol Cell Biochem 171, 69-73, 1997.10.1023/A:1006836001489Search in Google Scholar

Volpe SL. Magnesium in disease prevention and overall health. Adv Nutr 4, 378S-383S, 2013.10.3945/an.112.003483365051023674807Search in Google Scholar

Watson RT, Kanzaki M, Pessin JE. Regulated membrane traffi cking of the insulin-responsive glucose transporter 4 in adipocytes. Endocr Rev 25, 177-204, 2004.10.1210/er.2003-001115082519Open DOISearch in Google Scholar

Wu Y, Lu H, Yang H, Li C, Sang Q, Liu X, Liu Y, Wang Y, Sun Z. Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of AktGLUT4, GSK3beta and mTOR-S6K1. J Nutr Biochem 34, 126-135, 2016.10.1016/j.jnutbio.2016.05.00827295130Open DOISearch in Google Scholar

Yamada K, Yamakawa K, Terada Y, Kawaguchi K, Sugaya A, Sugiyama T, Toyoda N. Expression of GLUT4 glucose transporter protein in adipose tissue and skeletal muscle from streptozotocin-induced diabetic pregnant rats. Horm Metab Res 31, 508-513, 1999.10.1055/s-2007-97878510569252Search in Google Scholar

Yan ST, Li CL, Tian H, Li J, Pei Y, Liu Y, Gong YP, Fang FS, Sun BR. MiR-199a is overexpressed in plasma of type 2 diabetes patients which contributes to type 2 diabetes by targeting GLUT4. Mol Cell Biochem 397, 45-51, 2014.10.1007/s11010-014-2170-825084986Search in Google Scholar

Yavuz Y, Mollaoglu H, Yurumez Y, Ucok K, Duran L, Tunay K, Akgun L. Th erapeutic eff ect of magnesium sulphate on carbon monoxide toxicity-mediated brain lipid peroxidation. Eur Rev Med Pharmacol Sci 17, 28-33, 2013.Search in Google Scholar

Zhang W, Zhao J, Wang J, Pang X, Zhuang X, Zhu X. Hypo-glycemic eff ect of aqueous extract of seabuckthorn (Hippophae rhamnoides L.) seed residues in streptozotocin-induced diabetic rats. Phytother Res 24, 228-232, 2010.10.1002/ptr.291719585473Search in Google Scholar

Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski, JF, Hirshman MF, Virkamaki A, Goodyear LJ. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 6, 924-928, 2000.10.1038/7869310932232Search in Google Scholar