<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Activated charcoal was microencapsulated with <italic>Lactobacillus acidophilus</italic> 314 previously adapted for urea uptake. The creatinine removal capacity of this combination microcapsule was evaluated in-vitro in media simulating the small intestine. Results show that microcapsules containing both activated charcoal and <italic>L. acidophilus</italic> 314 demonstrated potential for decreasing creatinine. Interestingly, when co-encapsulating both activated charcoal and <italic>L. acidophilus</italic> 314 a smaller decrease in creatinine was observed than when encapsulating them separately. However, co-encapsulated microcapsules were more stable in various parts of the gastrointestinal system and survived longer in storage. These results suggest the feasibility of using microcapsules containing activated charcoal and probiotic bacteria as oral adjuvants for creatinine removal and provides a theoretical model for the use of these microcapsules to remove any unwanted metabolite.</p></abstract>

Activated charcoal was microencapsulated with Lactobacillus acidophilus 314 previously adapted for urea uptake. The creatinine removal capacity of this combination microcapsule was evaluated in-vitro in media simulating the small intestine. Results show that microcapsules containing both activated charcoal and L. acidophilus 314 demonstrated potential for decreasing creatinine. Interestingly, when co-encapsulating both activated charcoal and L. acidophilus 314 a smaller decrease in creatinine was observed than when encapsulating them separately. However, co-encapsulated microcapsules were more stable in various parts of the gastrointestinal system and survived longer in storage. These results suggest the feasibility of using microcapsules containing activated charcoal and probiotic bacteria as oral adjuvants for creatinine removal and provides a theoretical model for the use of these microcapsules to remove any unwanted metabolite.

Artificial cell microcapsules containing live bacterial cells and activated charcoal for managing renal failure creatinine: preparation and <italic>in-vitro</italic> analysis

Biomedical Technology and Cell Therapy Research Laboratory

Department of Biomedical Engineering and Artificial Cell and Organs Research Center, Faculty of Medicine

The EuroBiotech Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Artificial cell microcapsules containing live bacterial cells and activated charcoal for managing renal failure creatinine: preparation and  analysis

Activated charcoal was microencapsulated with Lactobacillus acidophilus 314 previously adapted for urea uptake. The creatinine removal capacity of this...

Artificial cell microcapsules containing live bacterial cells and activated charcoal for managing renal failure creatinine: preparation and in-vitro analysis

Published Online: Oct 23, 2019

Page range: 190 - 196

DOI: https://doi.org/10.2478/ebtj-2019-0023

Keywords
Artificial cell, activated charcoal, creatinine, microcapsules, oral therapy, renal failure, microbiome, live bacteria

© 2019 Trisna Lim et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Artificial cell microcapsules containing live bacterial cells and activated charcoal for managing renal failure creatinine: preparation and in-vitro analysis

Published Online: Oct 23, 2019

Page range: 190 - 196

DOI: https://doi.org/10.2478/ebtj-2019-0023

KeywordsArtificial cell, activated charcoal, creatinine, microcapsules, oral therapy, renal failure, microbiome, live bacteria

© 2019 Trisna Lim et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Artificial cell, activated charcoal, creatinine, microcapsules, oral therapy, renal failure, microbiome, live bacteria