Screening of metabolites from endophytic fungi of some Nigerian medicinal plants for antimicrobial activities
, , , , , , and | Jan 25, 2019
About this article
Article Category: Research Article
Published Online: Jan 25, 2019
Page range: 10 - 18
DOI: https://doi.org/10.2478/ebtj-2019-0002
Keywords
© 2019 Peter M. Eze, Joy C. Nnanna, Ugochukwu Okezie, Happiness S. Buzugbe, Chika C. Abba, Chidimma R. Chukwunwejim, Festus B. C. Okoye, Charles O. Esimone, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
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Result of antimicrobial assay of endophytic fungal extracts showing the inhibition zone diameters (IZDs) produced against test isolates
| IZDs (mm) | |||||||
|---|---|---|---|---|---|---|---|
| Test Organisms | NL-L1 | NL-L2 | SL-L1 | PPL-LAC | PPL-LE2 | Positive control Gentamicin (10 μg/ml) | Negative control DMSO |
| 0 | 9 | 7 | 3 | 4 | 17 | 0 | |
| 0 | 0 | 5 | 0 | 3 | 21 | 0 | |
| 0 | 6 | 6 | 0 | 0 | 22 | 0 | |
| 0 | 6 | 8 | 0 | 0 | 16 | 0 | |
| Ketoconazole (50 μg/ml) | DMSO | ||||||
| 0 | 0 | 0 | 0 | 0 | 17 | 0 | |
| 0 | 0 | 0 | 0 | 0 | 4 | 0 | |
Biological activities/applications of detected compounds
| Plants | Endophytic fungi | Compounds detected by HPLC analysis | Biological activities/applications | References |
|---|---|---|---|---|
| NL-L1 | Ethyl 4-hydroxyphenyl acetate | An intermediate for the preparation of anti-inflammatory agents | (42) | |
| Ferulic acid | Antioxidant anti-diabetic, antihypertensive, anticancer, anti-inflammatory, hepatoprotective, antimicrobial, anti-allergic, increase sperm viability, antithrombotic, antiviral and vasodilatory actions, metal chelation, modulation of enzyme activity, activation of transcriptional factors, gene expression and signal transduction activities | (43-54) | ||
| NL-L2 | Ruspolinone | Organocatalysts and building blocks in organic synthesis | (55,56) | |
| SL-L1 | Protocatechuic acid | Antioxidant, antimicrobial, anticancer, anti-ulcer, antidiabetic, anti-ageing, antifibrotic antiviral, anti-inflammatory, analgesic activity, anti-atherosclerotic, cardiac, hepatoprotective, neurological and nephroprotective activities | (57-71) | |
| Cladosporin | Antiplasmodial, antimicrobial, insecticidal, and antitumor activities | (72-76) | ||
| Scytalone | Plant growth promotion, intermediate in the biosynthesis of melanin in fungi | (77-80) | ||
| PPL-LAC PPL-LE2 | Indole-3-acetic acid Indole-3-acetic acid | Cytotoxic/anticancer, antioxidant, anti-inflammatory activities | (81-83) | |
| Indole-3-carbaldehyde | Cytotoxic and antibacterial activities, associated with the innate immunity to microbial pathogen infections in plants | (84-86) |