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People spend most of their adult lives in the workplace and at work. It is therefore essential to create an environment and working conditions that positively affect their work performance and well-being at work. Ergonomics is the science that studies the relationship between people and the environment that surrounds them on a daily basis. It is not only about achieving optimum work performance, but for companies ergonomics can save costs associated with health problems and physical and psychological illnesses of employees due to poor quality of life in the workplace. Even today, with the implementation of Industry 4.0 and increasing levels of automation and robotization, technological developments are enabling efficient production processes and bringing about changes in human work. With this comes the emergence of new threats to employee well-being and challenging their existing skills and knowledge. It is therefore essential to provide quality workplaces for the workforce that will be work-ing in the changed environment. The aim of this paper is to present how ergonomic rationalisation can be used to influence the quality of life in the workplace so that employees are able to perform optimally at work without negatively impacting on their health.