A Screening Method by Gas Chromatography-Mass Spectrometry for the Quantification of 24 Aerosol Constituents from Heat-Not-Burn Tobacco Products

1. Federal Drug Association (FDA): Established List of the Chemicals and Chemical Compounds Identified by FDA as Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke; Federal Register, Vol. 77, No. 64, 2012. Available at: https://www.gpo.gov/fdsys/pkg/FR-2012-04-03/pdf/2012-7727.pdf (accessed November 28, 2019)Search in Google Scholar

2. Health Canada: Tobacco Products Information Regulations; SOR/2000-273, Schedule 2, 2000. Available at: http://laws-lois.justice.gc.ca/PDF/SOR-2000-273.pdf (accessed November 28, 2019)Search in Google Scholar

3. World Health Organisation (WHO): Report on the Scientific Basis of Tobacco Product Regulation: 5^th Report of a WHO Study Group. WHO Technical Report Series, 989, 2015. Available at: https://www.who.int/tobacco/publications/prod_regulation/trs989/en/ (accessed November 28, 2019) ISBN: 978 92 4 120989 2 989Search in Google Scholar

4. Okaru, A.O. and D.W. Lachenmeier: The Food and Beverage Occurrence of Furfuryl Alcohol and Myrcene - Two Emerging Potential Human Carcinogens?; Toxics 5 (2017) 9. DOI: 10.3390/toxics501000910.3390/toxics5010009Open DOISearch in Google Scholar

5. Nanni, E.J., M.E. Lovette, R.D. Hicks, K.W. Fowler, and M.F. Borgerding: Separation and Quantitation of Phenolic Compounds in Mainstream Cigarette Smoke by Capillary Gas Chromatography with Mass Spectrometry in the Selected-Ion Mode; J. Chromatogr. A 505 (1990) 365–374. DOI: 10.1016/S0021-9673(01)93051-110.1016/S0021-9673(01)93051-1Open DOISearch in Google Scholar

6. Clark, T.J. and J.E. Bunch: Quantitative Determination of Phenols in Mainstream Smoke with Solid-Phase Microextraction-Gas Chromatography-Selected Ion Monitoring Mass Spectrometry; J. Chromatogr. Sci. 34 (1996) 272–275. Available at: https://academic.oup.com/chromsci/article-pdf/34/6/272/1094028/34-6-272.pdf (accessed November 28, 2019) DOI: 10.1093/chromsci/34.6.27210.1093/chromsci/34.6.272Open DOISearch in Google Scholar

7. Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA): Recommended Method No. 70: Determination of Selected Volatile Organic Compounds in the Mainstream Smoke of Cigarettes - Gas Chromatography-Mass Spectrometry Method; February 2018, Ref. SMA-163-CRM-70. Available at: https://www.coresta.org/determination-selected-volatile-organic-compoundsmainstream-smoke-cigarettes-gas-chromatography (accessed November 28, 2019)Search in Google Scholar

8. Kim, K.H. and S.K. Pandey: Determination of Hazardous VOCs and Nicotine Released from Mainstream Smoke by the Combination of the SPME and GC-MS Methods; The Scientific World Journal 10 (2010) 1318–1329. DOI: 10.1100/tsw.2010.12710.1100/tsw.2010.127576398920623090Search in Google Scholar

9. Darrall, K.G., J.F. Figgins, and R.D. Brown: Determination of Benzene and Associated Volatile Compounds in Mainstream Cigarette Smoke; Analyst 123 (1998) 1095–1101. DOI: 10.1039/A708664D10.1039/A708664Open DOISearch in Google Scholar

10. Rainey, C.L., J.R. Shifflett, J.V. Goodpaster, and D.Z. Bezabeh: Quantitative Analysis of Humectants in Tobacco Products Using Gas Chromatography (GC) with Simultaneous Mass Spectrometry (MSD) and Flame Ionization Detection (FID); Beitr. Tabakforsch. Int. 25 (2013) 576–585. DOI: 10.2478/cttr-2013-093410.2478/cttr-2013-0934Search in Google Scholar

11. Ferguson, K., M.J. Samide, C. Schmicker, T. Schenk, and A.M. Wilson: Determination of Additives in Cigarettes Utilizing Evolved Gas Analysis (EGA); Food Public Health 6 (2016) 33–37. DOI: 10.5923/j.fph.20160602.0110.5923/j.fph.20160602.01Open DOISearch in Google Scholar

12. Wright, C.: Standardized Methods for the Regulation of Cigarette-Smoke Constituents; Trends Anal. Chem. 66 (2015) 118–127. DOI: 10.1016/j.trac.2014.11.01110.1016/j.trac.2014.11.011Open DOISearch in Google Scholar

13. Schaller, J.P., D. Keller, L. Poget, P. Pratte, E. Kaelin, D. McHugh, G. Cudazzo, D. Smart, A.R. Tricker, L. Gautier, M. Yerly, R. Reis Pires, S. Le Bouhellec, D. Ghosh, I. Hofer, E. García, P. Vanscheeuwijck, and S. Maeder: Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical Composition, Genotoxicity, Cytotoxicity, and Physical Properties of the Aerosol; Regul. Toxicol. Pharmacol. 81 Suppl. 2 (2016) S27–S47. DOI: 10.1016/j.yrtph.2016.10.00110.1016/j.yrtph.2016.10.00127720919Open DOISearch in Google Scholar

14. Kentucky Tobacco Research & Development Center, University of Kentucky, 1401 University Drive, Lexington, KY 40546, USA, 859-257-5798. Available at: www.uky.edu/KTRDC/ (accessed November 28, 2019)Search in Google Scholar

15. Purkis, S. and M. Intorp: Analysis of Reference Cigarette Smoke Yield Data from 21 Laboratories for 28 Selected Analytes as a Guide to Selection of New CORESTA Recommended Methods; Beitr. Tabakforsch. Int. 26 (2014) 57–73. DOI: 10.2478/cttr-2014-001010.2478/cttr-2014-0010Open DOISearch in Google Scholar

16. Sampson, M.M., D.M. Chambers, D.Y. Pazo, F. Moliere, B.C. Blount, and C.H. Watson: Simultaneous Analysis of 22 Volatile Organic Compounds in Cigarette Smoke Using Gas Sampling Bags for High-Throughput Solid-Phase Microextraction; Anal. Chem. 86 (2014) 7088–7095. DOI: 10.1021/ac501551810.1021/ac5015518455341424933649Open DOISearch in Google Scholar

17. Eldridge, A., T.R. Betson, M.V. Gama, and K. McAdam: Variation in Tobacco and Mainstream Smoke Toxicant Yields from Selected Commercial Cigarette Products; Regul. Toxicol. Pharmacol. 71 (2015) 409–427. DOI: 10.1016/j.yrtph.2015.01.00610.1016/j.yrtph.2015.01.00625620723Open DOISearch in Google Scholar

18. World Health Organization (WHO): Standard Operating Procedure for Intense Smoking of Cigarettes; Tobacco Laboratory Network (TobLabNet) Official Method SOP01. Available at: https://apps.who.int/iris/bitstream/handle/10665/75261/9789241503891_eng.pdf;jsessionid=2B0C18E383EBAD7DAF7CF241EB143221?sequence=1 (accessed November 28, 2019)Search in Google Scholar

19. International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH): ICH Harmonized Tripartite Guideline. Validation of Analytical Procedures: Text and Methodology Q2(R1), 2005. Available at: http://www.gmp-compliance.org/guidemgr/files/Q2(R1).PDF (accessed November 28, 2019)Search in Google Scholar

20. Association of Official Agricultural Chemists (AOAC): Official Methods of Analysis (2012) Guidelines for standard method performance requirements, Appendix F. Available at: http://www.eoma.aoac.org/app_f.pdf (accessed November 28, 2019)Search in Google Scholar